Transcript of Speech and Q&A Conference Call Q2 - MorphoSys
Transcript of Speech and Q&A Conference Call Q2 - MorphoSys
Transcript of Speech and Q&A Conference Call Q2 - MorphoSys
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<strong>MorphoSys</strong> AG – <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Text<br />
August 2, 2012<br />
The spoken word shall prevail.<br />
Mario Brkulj, Senior Manager Corporate Communications & IR, <strong>MorphoSys</strong> AG<br />
Slide 2: Today on the <strong>Call</strong><br />
Good afternoon <strong>and</strong> welcome, this is Mario Brkulj, Senior Manager Corporate<br />
Communications <strong>and</strong> Investor Relations <strong>of</strong> <strong>MorphoSys</strong>. With Claudia currently traveling it’s<br />
my pleasure to welcome you today to our <strong>Q2</strong> 2012 conference call <strong>and</strong> thank you for<br />
participating. With me are Simon Moroney, our Chief Executive Officer <strong>and</strong> Jens Holstein,<br />
our Chief Financial Officer.<br />
During the call, we will talk about the Company’s financial results for the first six months <strong>of</strong><br />
2012. Simon will start by giving you an operational overview <strong>of</strong> the second quarter. Before we<br />
open the call for your questions, Jens will review the financial results <strong>of</strong> the first six months <strong>of</strong><br />
2012.<br />
Slide 3: Safe Harbor<br />
Before we start, I have to remind you that during this conference call we will present <strong>and</strong><br />
discuss certain forward-looking statements concerning the development <strong>of</strong> <strong>MorphoSys</strong>’s core<br />
technologies, the progress <strong>of</strong> its current research programs <strong>and</strong> the initiation <strong>of</strong> additional<br />
programs. Should actual conditions differ from the Company’s assumptions, actual results<br />
<strong>and</strong> actions may differ from those anticipated. You are therefore cautioned not to place<br />
undue reliance on such forward-looking statements, which speak only as <strong>of</strong> the date here<strong>of</strong>.<br />
I would now like to h<strong>and</strong> over to Simon Moroney.
Dr. Simon E. Moroney, CEO, <strong>MorphoSys</strong> AG<br />
Thank you Mario, <strong>and</strong> also from me, a warm welcome to the call.<br />
Slide 4: <strong>Q2</strong> 2012: Pipeline Update – 73 Therapeutic Antibody Programs Ongoing, 20 in<br />
Clinical Trials<br />
This was a quarter <strong>of</strong> solid operational progress. Today’s focus will be on our main valuedriver,<br />
our pipeline, which continued to develop well as we reported advances in several<br />
proprietary <strong>and</strong> partnered programs. In total, 73 programs are currently ongoing, as two new<br />
programs were started during the quarter. The number <strong>of</strong> programs in clinical development is<br />
20, with several programs on track to complete Phase 2 clinical trials by the end <strong>of</strong> the year.<br />
Slide 5: <strong>Q2</strong> 2012: Pipeline Update – Proprietary Portfolio<br />
I’ll start the review <strong>of</strong> <strong>Q2</strong> with our proprietary product portfolio. With our most advanced<br />
program, MOR103, the Phase 1b/2a trial in rheumatoid arthritis patients is complete <strong>and</strong> we<br />
are on track to report clinical data during this third quarter. For your orientation, we expect to<br />
make an announcement in the second half <strong>of</strong> September. We also expect to be able to<br />
announce results <strong>of</strong> the Phase 1 study in healthy volunteers <strong>of</strong> a sub-cutaneous formulation<br />
<strong>of</strong> MOR103 this quarter. Meanwhile, the phase 1b trial <strong>of</strong> MOR103 in multiple sclerosis<br />
patients continues on track.<br />
The second most advanced program in our proprietary portfolio is MOR208, being developed<br />
for B-cell malignancies. Enrollment in the US phase 1 trial in CLL was completed during the<br />
second quarter, <strong>and</strong> we will report the results <strong>of</strong> this study later in the year. We published<br />
some exciting pre-clinical data at the ASCO conference in June, which showed synergistic<br />
effects on target cell killing in models <strong>of</strong> lymphoma when MOR208 was combined with four<br />
different, existing cancer therapies, including the anti-CD20 antibodies rituximab <strong>and</strong><br />
<strong>of</strong>atumumab.<br />
To round out the proprietary portfolio, the ongoing clinical development <strong>of</strong> MOR202 for<br />
multiple myeloma continues as planned.<br />
Slide 6: <strong>Q2</strong> 2012: Pipeline Update – First HuCAL Antibody in Pivotal Trial<br />
Moving on to our partnered pipeline, the main news during the second quarter was around<br />
gantenerumab, the HuCAL, anti-amyloid-� antibody being developed by Roche for<br />
Alzheimer’s disease. Following discussions with the regulatory authorities, Roche has<br />
upgraded the ongoing phase 2 study to a phase 2/3, potentially pivotal trial. This is a major<br />
event which means <strong>of</strong> course that, given a favorable outcome to the trial, a filing for<br />
registration <strong>of</strong> the drug may be possible.<br />
I’m sure you’re all aware <strong>of</strong> the bapineuzumab data that was recently released. I want to<br />
make clear that although bapineuzumab is also an antibody targeting amyloid-� for the<br />
<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 2 <strong>of</strong> 17
treatment <strong>of</strong> Alzheimer’s disease, the data is <strong>of</strong> limited relevance to gantenerumab. The main<br />
reason for this is that the two antibodies are being tested in different patient populations.<br />
Whereas the ongoing phase 3 trials <strong>of</strong> bapineuzumab are being conducted in mild- to<br />
moderate Alzheimer’s disease patients, gantenerumab is being developed in prodromal, or<br />
early stage sufferers. This is an important difference, which reflects current underst<strong>and</strong>ing <strong>of</strong><br />
the disease, namely that once symptoms appear, it may be too late for therapeutic<br />
intervention, <strong>and</strong> that the best chance <strong>of</strong> treatment is to intervene at the earliest possible<br />
opportunity, to prevent the damaging effects associated with the build-up <strong>of</strong> �-amyloid<br />
plaques.<br />
Gantenerumab is the most advanced antibody being developed in this way. Needless to say,<br />
the medical need <strong>and</strong> commercial opportunity are enormous.<br />
Slide 7: Partnered Pipeline: Selected Phase 2 Programs - Outlook<br />
While gantenerumab is the first partnered compound to enter late-stage clinical development,<br />
several programs have the potential to progress to this stage fairly quickly. More specifically,<br />
various active phase 2 studies for three Novartis compounds - including BHQ880 in cancer<br />
<strong>and</strong> BYM338 in musculoskeletal diseases – as well as the Janssen compound CNTO888 in<br />
IPF are scheduled for completion by the end <strong>of</strong> this year. As a result, we could see clinical<br />
data being published by our partners for a number <strong>of</strong> these studies. Success in Phase 2<br />
could also mean <strong>of</strong> course additional Phase 3 programs adding maturity to our pipeline.<br />
Slide 8: <strong>Q2</strong> 2012: Pipeline Update – Partnered Pipeline (II)<br />
Regarding other partnered programs, there were several developments during the second<br />
quarter.<br />
First, our partner OncoMed presented data on both currently ongoing HuCAL antibody<br />
programs during <strong>and</strong> after the end <strong>of</strong> the quarter. Most importantly, phase 1 data on the anti<br />
Notch antibody OMP-59R5 presented at ASCO showed that the antibody was generally safe<br />
<strong>and</strong> a maximum tolerated dose was established. For OMP-18R5 OncoMed published<br />
preclinical data demonstrating potent anti-cancer activity <strong>and</strong> synergistic activity with<br />
st<strong>and</strong>ard-<strong>of</strong>-care chemotherapeutic agents <strong>of</strong> the antibody in multiple human tumor models.<br />
Second, as reported on clinicaltrials.gov, a phase 2 study by Novartis evaluating the safety,<br />
tolerability <strong>and</strong> efficacy <strong>of</strong> BYM338 in patients with sporadic inclusion body myositis has been<br />
completed. This HuCAL antibody is also the subject <strong>of</strong> a further two phase 2 trials.<br />
Third, our partner Bayer HealthCare received orphan drug status in the US for BAY94-9343<br />
for the treatment <strong>of</strong> mesothelioma. This drug c<strong>and</strong>idate is an antibody-drug conjugate<br />
comprising a HuCAL antibody against the target mesothelin, linked to a maytansinoid toxin.<br />
The program is currently in Phase 1 development.<br />
To complete the updates on partnered programs, our partner Janssen has reported<br />
commencing a new phase 2 trial <strong>of</strong> the HuCAL antibody CNTO1959. In this study,<br />
CNTO1959 will be compared with the marketed antibody Stelara in about 250 rheumatoid<br />
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arthritis patients. Meanwhile, development <strong>of</strong> CNTO1959 in psoriasis continues in separate<br />
Phase 1 <strong>and</strong> 2 trials.<br />
Slide 9: AbD Serotec<br />
I’ll conclude my operational review with AbD Serotec. The research market, which is heavily<br />
dependent on public research funding, continues to be challenging <strong>and</strong> this is reflected in<br />
AbD’s results this quarter. This is one <strong>of</strong> the reasons why the focus is increasingly on<br />
diagnostics <strong>and</strong> larger technology <strong>and</strong>/or collaborative transactions. We see these larger<br />
opportunities as being the main drivers <strong>of</strong> both revenue <strong>and</strong> pr<strong>of</strong>it for AbD for the remainder<br />
<strong>of</strong> the year. Meanwhile, we continue to focus on anti-drug-antibodies, where our HuCAL<br />
technology is particularly suited. The first products are already available: antibodies against<br />
Rituxan ® , Herceptin ® , Campath ® , <strong>and</strong> Avastin ® . New products for determination <strong>of</strong> Humira ® ,<br />
Stelara ® , <strong>and</strong> Remicade ® will follow shortly.<br />
That concludes my review <strong>of</strong> the quarter. I’d now like to h<strong>and</strong> over to Jens for the financial<br />
update.<br />
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Jens Holstein, CFO, <strong>MorphoSys</strong> AG<br />
Thank you, Simon.<br />
Ladies <strong>and</strong> Gentlemen, I would now like to guide you through the most important financial<br />
figures <strong>of</strong> the first six months <strong>of</strong> 2012.<br />
Slide 10: Consolidated Income Statement (IFRS)<br />
Total Group revenues amounted to 33.0 million € in the first six months <strong>of</strong> 2012, compared to<br />
66.6 million € in the same time period <strong>of</strong> the previous year. This decrease is still mainly a<br />
result <strong>of</strong> the significant one time milestone payment we received in Q1 2011 from Novartis<br />
due to the internalization <strong>of</strong> our HuCAL platform at Novartis’s premises in Basel.<br />
Total operating expenses decreased by approximately 20% to 35.0 million € compared to the<br />
first half <strong>of</strong> last year. The main reason for this development was a 25% decrease in R&D<br />
expenses to 21.2 million €. R&D expenses for proprietary product <strong>and</strong> technology<br />
development activities decreased to 12.3 million €. As we already explained in our Q1-call,<br />
the reduction results from the fact that costly production steps were already expensed in<br />
2011 <strong>and</strong> the phase 1b/2a trial <strong>of</strong> MOR103 in RA is meanwhile completed. Our S, G&A<br />
expenses also decreased by around 8% to 10.6 million €.<br />
In the first six months <strong>of</strong> 2012, the EBIT amounted to minus 1.9 million €, compared to 21.5<br />
million € in the first half <strong>of</strong> 2011. The net loss <strong>of</strong> 1 million € corresponded to a diluted loss per<br />
share <strong>of</strong> 4 Cents.<br />
Slide 11: Segment Reporting<br />
Let’s now have a closer look at our segment reporting. As in previous periods, nearly three<br />
quarters <strong>of</strong> total revenues arose from the therapeutic side <strong>of</strong> our business, with Partnered<br />
Discovery generating 23.4 million € in the first half <strong>of</strong> 2012, compared to 56.1 million € in the<br />
previous year.<br />
Revenues in the Proprietary Development segment amounted to 0.8 million €. Those<br />
revenues have been generated by our funded research activities for Novartis in connection<br />
with the two pre-development programs into which <strong>MorphoSys</strong> has the option to opt-in after<br />
the discovery phase.<br />
Looking at AbD Serotec, you can see that revenues slightly decreased to 8.8 million € in the<br />
first half <strong>of</strong> 2012, compared to 9.4 million € in the first six months <strong>of</strong> 2011. This decrease is a<br />
reflection <strong>of</strong> a weak second quarter, driven by an especially low dem<strong>and</strong> in the research<br />
market.<br />
Slide 12: Balance Sheet<br />
Let’s now take a look at the balance sheet. <strong>MorphoSys</strong>’s cash, securities <strong>and</strong> interestbearing<br />
assignable loans amounted to 133.5 million € at the end <strong>of</strong> the second quarter. Our<br />
<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 5 <strong>of</strong> 17
funds, together with the Company’s sound financial performance, are <strong>of</strong> great value for the<br />
company <strong>and</strong> our shareholders, especially in today’s market environment. As most <strong>of</strong> you<br />
know, our cash is reserved for selective strategic transactions, which strengthen our core<br />
business. The acquisition <strong>of</strong> Sloning on the technology side <strong>and</strong> the in-licensing <strong>of</strong> MOR208<br />
on the product side could act as role models for the kind <strong>of</strong> transactions we are looking to<br />
secure.<br />
Slide 13: Guidance 2012<br />
Before we open the call for your questions, we would like to reconfirm our financial guidance<br />
for 2012. With a number <strong>of</strong> commercial discussions currently ongoing we are confident to see<br />
an increased dynamic in our top-line results in the second half <strong>of</strong> the year compared to the<br />
first six months. As before, total group revenues are expected to amount to 75 – 80 million €<br />
this year. As previously explained, this guidance does not reflect a potential successful outlicensing<br />
<strong>of</strong> any <strong>of</strong> our proprietary programs, which could significantly increase revenues.<br />
Expenses for proprietary development activities will mainly include the clinical development<br />
<strong>of</strong> our most advanced drug c<strong>and</strong>idates as well as the development <strong>of</strong> new technologies <strong>and</strong><br />
are expected to be between 20 million € <strong>and</strong> 25 million €. For 2012, we anticipate an EBIT in<br />
the range <strong>of</strong> 1 million € to 5 million €.<br />
Ladies <strong>and</strong> Gentlemen, that concludes my review for the first six months <strong>of</strong> 2012, <strong>and</strong> I’ll now<br />
h<strong>and</strong> back to Mario for the Q&A session.<br />
Mario Brkulj, Senior Manager Corporate Communications & IR, <strong>MorphoSys</strong> AG<br />
Thank you. We will now open the call for your questions.<br />
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Questions & Answers<br />
Gunnar Romer, Deutsche Bank<br />
Good afternoon, everyone. Thanks for taking my question. First question is regarding the<br />
guidance outlook for the second half. You already mentioned that you're in ongoing<br />
discussions. I was just wondering to what extent you expect potentially higher revenues also<br />
in your partnered business excluding what is already ongoing? And, to what extent this really<br />
refers to Ylanthia?<br />
Then, secondly on the outlook for AbD, what are you seeing currently? Is there potential for<br />
improvement in the second half as well or do you think current trends would continue for the<br />
next couple <strong>of</strong> quarter? And the last question, you indicated that you've started two new<br />
programs but I didn't really get what these were. If you could repeat this, please.<br />
Dr. Simon Moroney, CEO <strong>of</strong> <strong>MorphoSys</strong> AG<br />
Sure, Gunnar, thanks for joining the call today. First <strong>of</strong> all, in terms <strong>of</strong> the guidance question,<br />
<strong>and</strong> where the revenue is coming from. We don't want to characterize that in detail, just let<br />
me say that as you know, we have a number <strong>of</strong> technologies, a number <strong>of</strong> existing<br />
partnerships. We're in a number <strong>of</strong> discussions with potential new partners. We have good<br />
visibility based on the status <strong>of</strong> some <strong>of</strong> those discussions <strong>and</strong> that visibility gives us the<br />
confidence to be able to confirm our guidance for the full year. But what we don't want to do<br />
at this stage is characterize with any precision about precisely what -how those<br />
collaborations or deals or partnerships may look, what technologies may or may not be<br />
involved <strong>and</strong> with whom they may be. But as I say, the visibility is sufficiently strong that<br />
we're happy to confirm our guidance for the full year.<br />
Regarding the question about AbD, as we mentioned during the presentation the research<br />
market is definitely weak. A lot <strong>of</strong> the scientists that are our customers who depend on grants<br />
from governments around the world, a lot <strong>of</strong> that grant funding has dried up to a large extent<br />
<strong>and</strong> the growth in that research market is close to zero, quite frankly at the moment. So - <strong>and</strong><br />
we don't expect that to change in the near term, certainly not before the end <strong>of</strong> the year.<br />
Nevertheless, we're confident that AbD will reach its targets, but the kinds <strong>of</strong> opportunities<br />
that we're looking at are rather larger deals with companies, commercial organizations, rather<br />
than selling antibodies to individual researchers. And as we mentioned, our increasing focus<br />
on bigger opportunities, diagnostics for example, helps us <strong>and</strong> will help AbD to reach its<br />
targets for the remainder <strong>of</strong> the year, rather than relying on that basic research business.<br />
Coming to your third question regarding the two new programs. Just to be very clear, these<br />
were two new program starts <strong>and</strong> we haven't, I believe, indicated where they came from, the<br />
origin <strong>of</strong> those programs, but you should have seen that they are new discovery programs,<br />
so they're coming in right at the front <strong>of</strong> the pipeline.<br />
Gunnar Romer<br />
Okay, thank you. But just with regard to the two new programs, that would mean that you<br />
have discontinued two as well?<br />
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Simon Moroney<br />
No, because the count at the last call, Q1, was 71.<br />
Gunnar Romer<br />
Right. Okay.<br />
Simon Moroney<br />
So, we added two now so that makes it 73 now.<br />
Gunnar Romer<br />
Okay. Then one final question on MOR103 <strong>and</strong> the upcoming data points. I mean you're<br />
already pretty precise in terms <strong>of</strong> timing, I was wondering whether this was just relating to the<br />
phase I/2 trial or whether we should expect subcutaneous data also in the second half <strong>of</strong><br />
September.<br />
Simon Moroney<br />
Yes, we haven't finalized the timing <strong>of</strong> those two announcements with precision, but we<br />
expect both sets <strong>of</strong> data to be available roughly around the same time <strong>and</strong> so precisely when<br />
we'll announce them we haven't yet finalized, but roughly around the same time.<br />
Gunnar Romer<br />
Okay, thank you.<br />
Daniel Wendorff, Commerzbank<br />
Good afternoon <strong>and</strong> thanks for taking my question, two if I may. Starting <strong>of</strong>f with your chart<br />
on page - on slide four, question from my side would be as you haven't specified the various<br />
partners for preclinical <strong>and</strong> discovery projects <strong>and</strong> aside from that I count six Novartis<br />
partnered programs as well as co-development programs, could you quantify the total<br />
number <strong>of</strong> programs you are working with or you have been working on for Novartis. That<br />
would be a helpful number for me.<br />
And second question would be on your investment guidance for proprietary R&D. Is it fair to<br />
assume that you would rather be in the lower half for 2012 than in the upper half <strong>of</strong> that<br />
guidance range? Any comment there would be helpful as well. Thank you very much.<br />
Simon Moroney, <strong>MorphoSys</strong> AG<br />
Okay, Daniel, thanks for the questions. I'll - let me take the first one <strong>and</strong> then Jens will take<br />
the second one. So in terms <strong>of</strong> the total number <strong>of</strong> Novartis programs, to tell you the truth, I<br />
don't have the precise number in mind, but I think it's fair to assume that its more than half <strong>of</strong><br />
the total number or around half, somewhere in that ballpark.<br />
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If you need a precise number, we may be able to get that to you, but as I say, the orientation<br />
it's around half approximately.<br />
Daniel Wendorff<br />
So maybe a quick question there, so half <strong>of</strong> the partner programs, or half <strong>of</strong> the 73 overall.<br />
Simon Moroney<br />
Half <strong>of</strong> the partnered, sorry.<br />
Daniel Wendorff<br />
Yes, okay.<br />
Simon Moroney<br />
30 odd, low 30 something like that.<br />
Daniel Wendorff<br />
Okay.<br />
Jens Holstein, CFO <strong>of</strong> <strong>MorphoSys</strong> AG<br />
And on the R&D expenses for proprietary, its - I mean we just reiterated our guidance for 20<br />
to 25 <strong>and</strong> we would like to keep it at that level. We haven't specified it nearer <strong>and</strong> I wouldn't<br />
like to do that at this point in time.<br />
Daniel Wendorff<br />
Yes, fair enough. Thank you.<br />
Gary Wa<strong>and</strong>ers, Nomura Securities<br />
Hi there. Excuse me. Just a question on the AbD Serotec revenue <strong>and</strong> the focus on<br />
diagnostics. There are already a number <strong>of</strong> anti-monoclonal - anti therapeutic monoclonal<br />
antibodies now available through AbD Serotec. Can you give us an idea <strong>of</strong> how much <strong>of</strong> the<br />
turnover <strong>of</strong> 8.8 was due to sales related to these sorts <strong>of</strong> programs? And what your sort <strong>of</strong><br />
goal long term might be, as a proportion?<br />
Simon Moroney<br />
Yes, Gary, I think it's safe to assume that the contribution is not substantial at this stage. The<br />
newly launched product which is just getting going. We do hope <strong>and</strong> expect them to pick up<br />
<strong>and</strong> the beauty <strong>of</strong> these kinds <strong>of</strong> products, <strong>of</strong> course is that those royalty streams that flow to<br />
us are pure pr<strong>of</strong>it <strong>and</strong> so the intention <strong>and</strong> the belief here is that over time as they - as those<br />
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products grow, they will also contribute to an increase in the underlying pr<strong>of</strong>it margin <strong>of</strong> the<br />
business <strong>and</strong> that's one <strong>of</strong> the reasons why we expect in the years to come that the pr<strong>of</strong>it<br />
margin for AbD can improve significantly beyond the current sort <strong>of</strong> midsingle digits net that<br />
we have at the moment into somewhere into the mid teens <strong>and</strong> if not into the 20% range. But<br />
its early days yet, these are br<strong>and</strong> new products, they're just getting going <strong>and</strong> the<br />
contribution is not substantial at this stage.<br />
Gary Wa<strong>and</strong>ers<br />
Okay, <strong>and</strong> if I might just quickly on MOR103, will you have the complete data analysis at that<br />
point when you release the report or will there be further analysis to conduct after that?<br />
Simon Moroney<br />
It will be a pretty complete package that we'll be able to announce in the second half <strong>of</strong><br />
September. So, it will be more than simply headline data.<br />
Gary Wa<strong>and</strong>ers<br />
Okay.<br />
Simon Moroney<br />
So we're taking the opportunity to really go through the data in detail <strong>and</strong> get a<br />
comprehensive <strong>and</strong> we hope meaningful package.<br />
Gary Wa<strong>and</strong>ers<br />
Okay, thanks very much.<br />
Elmar Kraus, DZ Bank<br />
Good afternoon, gentlemen, <strong>and</strong> thanks for taking my question. The first one with the<br />
EBITDA margin has just been answered so I'm left with just one more that's on the overall<br />
revenue line. Considering the fact that you had one milestone payment in the last quarter <strong>and</strong><br />
still, inverted commas, “only” an overall revenue <strong>of</strong> 16.5, is it fair to assume that you now<br />
have reached your baseline revenue quantity <strong>of</strong> let's say around 15 million. Is that fair to say?<br />
Thank you.<br />
Jens Holstein, CFO <strong>of</strong> <strong>MorphoSys</strong> AG<br />
Yes, <strong>and</strong> thanks for the question. Well just maybe to clarify the <strong>Q2</strong> figure was 16.9.<br />
Elmar Kraus<br />
Sorry.<br />
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Jens Holstein<br />
Yeah, no worries. As you know, I mean there are - the milestone payments are coming in<br />
special deals on technologies <strong>and</strong> so on they're also coming in. So there is a fluctuation. As<br />
you know, what's safe in terms <strong>of</strong> the top line is always what we get from Novartis for FTE<br />
funding as well as for the license fee <strong>and</strong> on top <strong>of</strong> that, there will be always millions on - for<br />
this sort <strong>of</strong> deals which have been mentioned by Simon before <strong>and</strong> which I just mentioned.<br />
So, I can't confirm what you're saying that it is a decision ballpark which like “on 15 million it’s<br />
safe”. There will be fluctuations in the future <strong>and</strong> certainly we are aiming that the numbers by<br />
quarter are higher than what you have just addressed as the number.<br />
Elmar Kraus<br />
Thank you.<br />
Thomas Schiessle, EQUI.TS<br />
Thomas Schiessle from EQUI.TS in Frankfurt. Hello gentlemen. I would like to ask two<br />
questions, one on Ylanthia. Simon could you - could you confirm whether there might be at<br />
least one deal in the current business year? A technology deal?<br />
And the other question is on the partners portfolio, the recent fluctuation <strong>of</strong> the number <strong>of</strong><br />
partnered projects is approximately between 65, some more, some less. Is this the run rate<br />
we shall assume for the future? So, you are working at some 60 projects in the future as<br />
well? Thank you for clarification.<br />
Simon Moroney, <strong>MorphoSys</strong> AG<br />
Thanks, Thomas. Nice to hear from you. Just in terms <strong>of</strong> the types <strong>of</strong> deals that we're going<br />
to be doing between now <strong>and</strong> year end, as we indicated. We're confident based on the<br />
technologies we have to enter deals, let me say plural, until year end. We anticipate that<br />
Ylanthia will be a component <strong>of</strong> the activities that we engage in before year end, but you<br />
should think in terms <strong>of</strong> kind <strong>of</strong> packages <strong>of</strong> technology as well. The Slonomics platform for<br />
example is an integral part <strong>of</strong> what we have to <strong>of</strong>fer today. We see it being used in<br />
conjunction with Ylanthia for example. So, we're really in the nice position <strong>of</strong> having a suite <strong>of</strong><br />
technologies if you like that we can <strong>of</strong>fer <strong>and</strong> its therefore difficult to think about how<br />
individual deals might look <strong>and</strong> we don't really want to get into detailed discussions <strong>of</strong> that at<br />
this stage, but all <strong>of</strong> the - all <strong>of</strong> the technologies that we've developed <strong>and</strong> that are available<br />
are a subject <strong>of</strong> those discussions that are currently ongoing.<br />
In terms <strong>of</strong> the partnered portfolio, the way we think about this is that the number <strong>of</strong> new<br />
starts we're always aiming at somewhere in the ballpark <strong>of</strong> 10 or so per year. What is difficult<br />
to predict is the attrition rate, how many ongoing programs fall out <strong>and</strong> at what time they fall<br />
out. That's a little bit hard to predict, it can go in waves. But we hope that the net effect<br />
overall is that the total number <strong>of</strong> programs increases. Okay, but again, given the<br />
unpredictability <strong>of</strong> attrition, it's hard to predict at what rate that total will increase, but we do<br />
<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 11 <strong>of</strong> 17
anticipate <strong>and</strong> expect <strong>and</strong> plan for a continuous increase in the number <strong>of</strong> - or a steady<br />
increase year on year in the number <strong>of</strong> programs that are actually started.<br />
Thomas Schiessle<br />
So the number <strong>of</strong> employees working on those projects will still be the same range.<br />
Simon Moroney<br />
To the extent that new deals come in, which require collaboration <strong>and</strong> support on our side<br />
then new employees may be necessary to do those. Just that currently the bulk <strong>of</strong> employees<br />
working on these partnered projects are assigned to Novartis, as you know, <strong>and</strong> that is<br />
essentially a steady state. So that number <strong>of</strong> FTEs is fixed <strong>and</strong> doesn't change <strong>and</strong> is based<br />
on the inflow <strong>of</strong> programs, targets that come to us from Novartis. But beyond that, new deals<br />
could mean new employees.<br />
Thomas Schiessle<br />
Okay, may I ask an additional question on AbD?<br />
Simon Moroney<br />
Please. Yes.<br />
Thomas Schiessle<br />
You emphasized that the research market is more <strong>of</strong> less down, so you switched to - luckily<br />
you switched to a more to diagnostics. How - what amount <strong>of</strong> investments in - you have to<br />
spend to be in a good position to run this business with diagnostic. Is there anything to spend<br />
in the near future or is this ongoing investment?<br />
Simon Moroney<br />
Yes, the investments aren't huge here. That's really the beauty <strong>of</strong> this business. Its - what<br />
we're doing is we're really taking advantage <strong>of</strong> preexisting expertise that we have around the<br />
HuCAL technology <strong>and</strong> the HuCAL - <strong>of</strong> course applying the HuCAL technology itself, which<br />
turns out to have certain genuine advantages in the diagnostic setting, in addition to its<br />
already established <strong>and</strong> known advantages <strong>and</strong> therapeutics. And amongst these<br />
advantages is the ability to make anti idiotypic antibodies, which is the subject <strong>of</strong> all these<br />
products that we talked about during the presentation.<br />
So to - actually we're - <strong>and</strong> AbD is kind <strong>of</strong> blessed with having this existing expertise <strong>and</strong><br />
technology platform which is now simply being applied in a new area. So, it's a relatively easy<br />
step for us to take to move into this diagnostic space.<br />
Thomas Schiessle<br />
Okay, thanks for the information. Thank you.<br />
<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 12 <strong>of</strong> 17
Daniel Wendorff, Commerzbank<br />
Thanks for taking my follow up for question <strong>and</strong> that is also related to the potential<br />
partnerships or technology deals you might find <strong>and</strong> do in the second half <strong>of</strong> 2012. Is it fair to<br />
assume that it's also an - well, how shall I say that, a possibility <strong>and</strong> that might also be a<br />
HuCAL partnership in the area <strong>of</strong> infectious diseases? Or is that not something which you<br />
would regard as likely? Thank you.<br />
Simon Moroney, <strong>MorphoSys</strong> AG<br />
Could be.<br />
Daniel Wendorff<br />
Okay.<br />
Simon Moroney<br />
That's - you've rightly spotted <strong>of</strong> course that we have freedom to - full freedom to operate with<br />
HuCAL in the infectious disease space <strong>and</strong> amongst the list <strong>of</strong> discussions, negotiations <strong>and</strong><br />
things that are ongoing that is included.<br />
Daniel Wendorff<br />
Okay, so you have discussions in that area with potential partners.<br />
Simon Moroney<br />
Yes.<br />
Daniel Wendorff<br />
Okay, thanks.<br />
Sachin Soni, Kempen & Co.<br />
Good afternoon everyone. I have three questions. First is regarding the current status <strong>of</strong><br />
technology platform, you have upgraded the platform substantially after certain acquisitions,<br />
do you think there is still more room for improvements if yes, what direction would you go in<br />
improving the current technology platform.<br />
Then second is, regarding out licensing strategy. Is it correct to assume that you're internal<br />
biases towards out licensing <strong>and</strong> asset after pro<strong>of</strong> <strong>of</strong> concept or would you consider your<br />
proprietary assets to be out licensed earlier than that as well?<br />
<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 13 <strong>of</strong> 17
And third question, the potential deal on technology platform which we have been talking, am<br />
I underst<strong>and</strong>ing correctly to assume that this deal is a part <strong>of</strong> guidance already in revenues?<br />
Thank you.<br />
Simon Moroney, <strong>MorphoSys</strong><br />
Okay, thanks Sachin. Let me start with the technology platform. So, first <strong>of</strong> all, it cannot be<br />
improved further probably. We think that there are ways in which what we have can be<br />
exp<strong>and</strong>ed <strong>and</strong> proved, made more useful <strong>and</strong> if you think about it, it's really around the<br />
potential application for antibodies. The challenges at the moment are what types <strong>of</strong> targets<br />
can you hit. There are definitely classes <strong>of</strong> targets at the moment that are difficult to hit,<br />
which it would be great if you could go after <strong>and</strong> I think GPCRs, ion channels <strong>and</strong> so on, this<br />
is well known in the community. Could you get antibodies into cells for example <strong>and</strong> thereby<br />
access a whole new class <strong>of</strong> targets? Could you administer antibodies differently than<br />
intravenously or subcutaneously? So, it's a fantastic class <strong>of</strong> drugs, but there's definitely<br />
scope to improve on it further <strong>and</strong> these are some <strong>of</strong> the challenges - just some <strong>of</strong> the<br />
challenges that we are thinking about at the moment.<br />
While we're on the subject <strong>of</strong> technologies, I'll come to your third question which is are the<br />
types <strong>of</strong> deals that we referred to included in the guidance for the remainder <strong>of</strong> the year, the<br />
answer is definitely a yes to that one.<br />
And then finally, coming back to your second question in terms <strong>of</strong> out licensing, the intention<br />
for MOR103 is certainly not to take that forward in an indication like rheumatoid arthritis on<br />
our own <strong>and</strong> we feel that given good pro<strong>of</strong> <strong>of</strong> concept data that's an ideal time to find a good<br />
partner for that program. For the remaining programs, MOR208 <strong>and</strong> MOR202 for example,<br />
the current plan is to go to pro<strong>of</strong> <strong>of</strong> concept, because we feel that that's where we can<br />
establish the greatest value for those two programs <strong>and</strong> not to partner them earlier than that.<br />
That is the plan that we have for those two remaining programs.<br />
Sachin Soni<br />
Great, thank you.<br />
Gary Wa<strong>and</strong>ers, Nomura Securities<br />
Hi there, just to follow up on the platform discussion. Has there been any noticeable shift in<br />
the collaborative efforts with Novartis following the internalization <strong>of</strong> the HuCAL platform? It’s<br />
kind <strong>of</strong> the first part <strong>of</strong> that. And what is their stance vis a vis Ylanthia <strong>and</strong> development,<br />
discovery programs. Thanks.<br />
Simon Moroney, <strong>MorphoSys</strong> AG<br />
So, thanks Gary. Regarding the first part <strong>of</strong> that question, it was always part <strong>of</strong> the deal that<br />
they would internalize the HuCAL platform <strong>and</strong> it was also always part <strong>of</strong> the deal that there<br />
would be a constant, a steady state number <strong>of</strong> programs that would be pursued here. And<br />
that continues to be the case. So, the fact that they've internalized the HuCAL platform<br />
<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 14 <strong>of</strong> 17
doesn't really have any bearing on the collaboration as such because there's a constant<br />
amount <strong>of</strong> work going on.<br />
Gary Wa<strong>and</strong>ers<br />
Okay.<br />
Simon Moroney<br />
New targets come in as old targets are h<strong>and</strong>ed back or targets that have been worked up are<br />
h<strong>and</strong>ed back.<br />
With regards to Ylanthia, our view is that Ylanthia is a more <strong>and</strong> will be a more powerful<br />
technology than HuCAL. We believe therefore that it's the technology <strong>of</strong> choice for all<br />
therapeutic applications. We therefore absolutely want to have that as a part <strong>of</strong> our<br />
collaboration with Novartis <strong>and</strong> we're currently working closely with Novartis to figure out how<br />
that will precisely work <strong>and</strong> at what stage it should be brought into the collaboration, but that's<br />
absolutely the joint intention <strong>of</strong> the two parties that we together use the Ylanthia platform to<br />
make the next generation <strong>of</strong> therapeutic antibodies.<br />
Gary Wa<strong>and</strong>ers<br />
Okay, thanks.<br />
Gunnar Romer, Deutsche Bank<br />
Thanks for taking my follow up. This would be probably a question for Jens. I was wondering<br />
whether you could give us an idea <strong>of</strong> why the uptake in SG&A, what's behind that <strong>and</strong> then<br />
also with regard to partnered R&D, I noticed, was a little bit higher in <strong>Q2</strong>. Just was curious<br />
about whether there's a relationship also between partnered R&D <strong>and</strong> SG&A here?<br />
Jens Holstein, <strong>MorphoSys</strong> AG<br />
First, thanks Gunnar for the question. First maybe coming to the second question which you<br />
have addressed in the partner business. In absolute terms you're right, the amount went up<br />
but please be reminded that there is also - there are also some technology development<br />
expenses in there <strong>and</strong> this is certainly influencing the figures <strong>and</strong> here, I think we also see<br />
fluctuations. So therefore, I think in terms <strong>of</strong> what we have seen in the first half <strong>of</strong> last year as<br />
spending <strong>and</strong> in the first half <strong>of</strong> this year as spending for the partner business. You run in the<br />
sort <strong>of</strong> range <strong>of</strong> 9 to 11 million for that segment which we run <strong>and</strong> I think something like this is<br />
pretty much stable for each half year. So, I mean if you think <strong>of</strong> your model, I think something<br />
like this ballpark is pretty much okay.<br />
In terms <strong>of</strong> the SG&A expenses, I mean you have seen that we'll have in comparison to the<br />
first - so the second three months for the second quarter <strong>of</strong> last year that we have reduced<br />
our SG&A expenses <strong>and</strong> as such, I think we assumed that also in terms <strong>of</strong> the full year when<br />
we are not too far away <strong>of</strong> what we have seen for the first half year in terms <strong>of</strong> what we can<br />
<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 15 <strong>of</strong> 17
expect <strong>of</strong> total expenses. I mean there is some specifics always, some consultancy expenses<br />
which cause some deviation, but in that sort <strong>of</strong> ballpark, I think assumptions are well placed.<br />
Gunnar Romer<br />
Okay, that's helpful, but there's no significant let's say kind <strong>of</strong> upfront investments for<br />
upcoming technology deals that might go away in the second half.<br />
Jens Holstein<br />
Well, most likely those technology deals will be CapEx for us.<br />
Gunnar Romer<br />
Right. Okay.<br />
Jens Holstein<br />
Yes, <strong>and</strong> as such, we would book them accordingly.<br />
Gunnar Romer<br />
Okay, thank you.<br />
<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 16 <strong>of</strong> 17
Dr. Simon E. Moroney, CEO, <strong>MorphoSys</strong> AG<br />
To conclude the call, I’d like to remind you <strong>of</strong> the main points to take away. First, the<br />
Company’s greatest source <strong>of</strong> value, its drug pipeline, continues to develop well. We are on<br />
track to report clinical data from our two most advanced programs MOR103 <strong>and</strong> MOR208<br />
later this year as planned. Second, our partnered pipeline continues to grow <strong>and</strong> to mature<br />
with the transition <strong>of</strong> gantenerumab to a potentially pivotal trial for Alzheimer’s disease being<br />
the main highlight. And finally, we’re happy to re-confirm that we are on track to hit our<br />
financial targets for the year.<br />
Mario Brkulj, Senior Manager Corporate Communications & IR, <strong>MorphoSys</strong> AG<br />
That concludes the call. If any <strong>of</strong> you would like to follow up, we are in the <strong>of</strong>fice for the<br />
remainder <strong>of</strong> the day. Thank you for your participation on the call <strong>and</strong> goodbye.<br />
HuCAL ® , HuCAL GOLD ® , HuCAL PLATINUM ® , Ylanthia ® , CysDisplay ® , RapMAT ® <strong>and</strong><br />
arYla ® are registered trademarks <strong>of</strong> <strong>MorphoSys</strong> AG.<br />
Slonomics ® is a registered trademark <strong>of</strong> Sloning BioTechnology GmbH, a subsidiary <strong>of</strong><br />
<strong>MorphoSys</strong> AG.<br />
<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 17 <strong>of</strong> 17