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Transcript of Speech and Q&A Conference Call Q2 - MorphoSys

Transcript of Speech and Q&A Conference Call Q2 - MorphoSys

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<strong>MorphoSys</strong> AG – <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Text<br />

August 2, 2012<br />

The spoken word shall prevail.<br />

Mario Brkulj, Senior Manager Corporate Communications & IR, <strong>MorphoSys</strong> AG<br />

Slide 2: Today on the <strong>Call</strong><br />

Good afternoon <strong>and</strong> welcome, this is Mario Brkulj, Senior Manager Corporate<br />

Communications <strong>and</strong> Investor Relations <strong>of</strong> <strong>MorphoSys</strong>. With Claudia currently traveling it’s<br />

my pleasure to welcome you today to our <strong>Q2</strong> 2012 conference call <strong>and</strong> thank you for<br />

participating. With me are Simon Moroney, our Chief Executive Officer <strong>and</strong> Jens Holstein,<br />

our Chief Financial Officer.<br />

During the call, we will talk about the Company’s financial results for the first six months <strong>of</strong><br />

2012. Simon will start by giving you an operational overview <strong>of</strong> the second quarter. Before we<br />

open the call for your questions, Jens will review the financial results <strong>of</strong> the first six months <strong>of</strong><br />

2012.<br />

Slide 3: Safe Harbor<br />

Before we start, I have to remind you that during this conference call we will present <strong>and</strong><br />

discuss certain forward-looking statements concerning the development <strong>of</strong> <strong>MorphoSys</strong>’s core<br />

technologies, the progress <strong>of</strong> its current research programs <strong>and</strong> the initiation <strong>of</strong> additional<br />

programs. Should actual conditions differ from the Company’s assumptions, actual results<br />

<strong>and</strong> actions may differ from those anticipated. You are therefore cautioned not to place<br />

undue reliance on such forward-looking statements, which speak only as <strong>of</strong> the date here<strong>of</strong>.<br />

I would now like to h<strong>and</strong> over to Simon Moroney.


Dr. Simon E. Moroney, CEO, <strong>MorphoSys</strong> AG<br />

Thank you Mario, <strong>and</strong> also from me, a warm welcome to the call.<br />

Slide 4: <strong>Q2</strong> 2012: Pipeline Update – 73 Therapeutic Antibody Programs Ongoing, 20 in<br />

Clinical Trials<br />

This was a quarter <strong>of</strong> solid operational progress. Today’s focus will be on our main valuedriver,<br />

our pipeline, which continued to develop well as we reported advances in several<br />

proprietary <strong>and</strong> partnered programs. In total, 73 programs are currently ongoing, as two new<br />

programs were started during the quarter. The number <strong>of</strong> programs in clinical development is<br />

20, with several programs on track to complete Phase 2 clinical trials by the end <strong>of</strong> the year.<br />

Slide 5: <strong>Q2</strong> 2012: Pipeline Update – Proprietary Portfolio<br />

I’ll start the review <strong>of</strong> <strong>Q2</strong> with our proprietary product portfolio. With our most advanced<br />

program, MOR103, the Phase 1b/2a trial in rheumatoid arthritis patients is complete <strong>and</strong> we<br />

are on track to report clinical data during this third quarter. For your orientation, we expect to<br />

make an announcement in the second half <strong>of</strong> September. We also expect to be able to<br />

announce results <strong>of</strong> the Phase 1 study in healthy volunteers <strong>of</strong> a sub-cutaneous formulation<br />

<strong>of</strong> MOR103 this quarter. Meanwhile, the phase 1b trial <strong>of</strong> MOR103 in multiple sclerosis<br />

patients continues on track.<br />

The second most advanced program in our proprietary portfolio is MOR208, being developed<br />

for B-cell malignancies. Enrollment in the US phase 1 trial in CLL was completed during the<br />

second quarter, <strong>and</strong> we will report the results <strong>of</strong> this study later in the year. We published<br />

some exciting pre-clinical data at the ASCO conference in June, which showed synergistic<br />

effects on target cell killing in models <strong>of</strong> lymphoma when MOR208 was combined with four<br />

different, existing cancer therapies, including the anti-CD20 antibodies rituximab <strong>and</strong><br />

<strong>of</strong>atumumab.<br />

To round out the proprietary portfolio, the ongoing clinical development <strong>of</strong> MOR202 for<br />

multiple myeloma continues as planned.<br />

Slide 6: <strong>Q2</strong> 2012: Pipeline Update – First HuCAL Antibody in Pivotal Trial<br />

Moving on to our partnered pipeline, the main news during the second quarter was around<br />

gantenerumab, the HuCAL, anti-amyloid-� antibody being developed by Roche for<br />

Alzheimer’s disease. Following discussions with the regulatory authorities, Roche has<br />

upgraded the ongoing phase 2 study to a phase 2/3, potentially pivotal trial. This is a major<br />

event which means <strong>of</strong> course that, given a favorable outcome to the trial, a filing for<br />

registration <strong>of</strong> the drug may be possible.<br />

I’m sure you’re all aware <strong>of</strong> the bapineuzumab data that was recently released. I want to<br />

make clear that although bapineuzumab is also an antibody targeting amyloid-� for the<br />

<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 2 <strong>of</strong> 17


treatment <strong>of</strong> Alzheimer’s disease, the data is <strong>of</strong> limited relevance to gantenerumab. The main<br />

reason for this is that the two antibodies are being tested in different patient populations.<br />

Whereas the ongoing phase 3 trials <strong>of</strong> bapineuzumab are being conducted in mild- to<br />

moderate Alzheimer’s disease patients, gantenerumab is being developed in prodromal, or<br />

early stage sufferers. This is an important difference, which reflects current underst<strong>and</strong>ing <strong>of</strong><br />

the disease, namely that once symptoms appear, it may be too late for therapeutic<br />

intervention, <strong>and</strong> that the best chance <strong>of</strong> treatment is to intervene at the earliest possible<br />

opportunity, to prevent the damaging effects associated with the build-up <strong>of</strong> �-amyloid<br />

plaques.<br />

Gantenerumab is the most advanced antibody being developed in this way. Needless to say,<br />

the medical need <strong>and</strong> commercial opportunity are enormous.<br />

Slide 7: Partnered Pipeline: Selected Phase 2 Programs - Outlook<br />

While gantenerumab is the first partnered compound to enter late-stage clinical development,<br />

several programs have the potential to progress to this stage fairly quickly. More specifically,<br />

various active phase 2 studies for three Novartis compounds - including BHQ880 in cancer<br />

<strong>and</strong> BYM338 in musculoskeletal diseases – as well as the Janssen compound CNTO888 in<br />

IPF are scheduled for completion by the end <strong>of</strong> this year. As a result, we could see clinical<br />

data being published by our partners for a number <strong>of</strong> these studies. Success in Phase 2<br />

could also mean <strong>of</strong> course additional Phase 3 programs adding maturity to our pipeline.<br />

Slide 8: <strong>Q2</strong> 2012: Pipeline Update – Partnered Pipeline (II)<br />

Regarding other partnered programs, there were several developments during the second<br />

quarter.<br />

First, our partner OncoMed presented data on both currently ongoing HuCAL antibody<br />

programs during <strong>and</strong> after the end <strong>of</strong> the quarter. Most importantly, phase 1 data on the anti<br />

Notch antibody OMP-59R5 presented at ASCO showed that the antibody was generally safe<br />

<strong>and</strong> a maximum tolerated dose was established. For OMP-18R5 OncoMed published<br />

preclinical data demonstrating potent anti-cancer activity <strong>and</strong> synergistic activity with<br />

st<strong>and</strong>ard-<strong>of</strong>-care chemotherapeutic agents <strong>of</strong> the antibody in multiple human tumor models.<br />

Second, as reported on clinicaltrials.gov, a phase 2 study by Novartis evaluating the safety,<br />

tolerability <strong>and</strong> efficacy <strong>of</strong> BYM338 in patients with sporadic inclusion body myositis has been<br />

completed. This HuCAL antibody is also the subject <strong>of</strong> a further two phase 2 trials.<br />

Third, our partner Bayer HealthCare received orphan drug status in the US for BAY94-9343<br />

for the treatment <strong>of</strong> mesothelioma. This drug c<strong>and</strong>idate is an antibody-drug conjugate<br />

comprising a HuCAL antibody against the target mesothelin, linked to a maytansinoid toxin.<br />

The program is currently in Phase 1 development.<br />

To complete the updates on partnered programs, our partner Janssen has reported<br />

commencing a new phase 2 trial <strong>of</strong> the HuCAL antibody CNTO1959. In this study,<br />

CNTO1959 will be compared with the marketed antibody Stelara in about 250 rheumatoid<br />

<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 3 <strong>of</strong> 17


arthritis patients. Meanwhile, development <strong>of</strong> CNTO1959 in psoriasis continues in separate<br />

Phase 1 <strong>and</strong> 2 trials.<br />

Slide 9: AbD Serotec<br />

I’ll conclude my operational review with AbD Serotec. The research market, which is heavily<br />

dependent on public research funding, continues to be challenging <strong>and</strong> this is reflected in<br />

AbD’s results this quarter. This is one <strong>of</strong> the reasons why the focus is increasingly on<br />

diagnostics <strong>and</strong> larger technology <strong>and</strong>/or collaborative transactions. We see these larger<br />

opportunities as being the main drivers <strong>of</strong> both revenue <strong>and</strong> pr<strong>of</strong>it for AbD for the remainder<br />

<strong>of</strong> the year. Meanwhile, we continue to focus on anti-drug-antibodies, where our HuCAL<br />

technology is particularly suited. The first products are already available: antibodies against<br />

Rituxan ® , Herceptin ® , Campath ® , <strong>and</strong> Avastin ® . New products for determination <strong>of</strong> Humira ® ,<br />

Stelara ® , <strong>and</strong> Remicade ® will follow shortly.<br />

That concludes my review <strong>of</strong> the quarter. I’d now like to h<strong>and</strong> over to Jens for the financial<br />

update.<br />

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Jens Holstein, CFO, <strong>MorphoSys</strong> AG<br />

Thank you, Simon.<br />

Ladies <strong>and</strong> Gentlemen, I would now like to guide you through the most important financial<br />

figures <strong>of</strong> the first six months <strong>of</strong> 2012.<br />

Slide 10: Consolidated Income Statement (IFRS)<br />

Total Group revenues amounted to 33.0 million € in the first six months <strong>of</strong> 2012, compared to<br />

66.6 million € in the same time period <strong>of</strong> the previous year. This decrease is still mainly a<br />

result <strong>of</strong> the significant one time milestone payment we received in Q1 2011 from Novartis<br />

due to the internalization <strong>of</strong> our HuCAL platform at Novartis’s premises in Basel.<br />

Total operating expenses decreased by approximately 20% to 35.0 million € compared to the<br />

first half <strong>of</strong> last year. The main reason for this development was a 25% decrease in R&D<br />

expenses to 21.2 million €. R&D expenses for proprietary product <strong>and</strong> technology<br />

development activities decreased to 12.3 million €. As we already explained in our Q1-call,<br />

the reduction results from the fact that costly production steps were already expensed in<br />

2011 <strong>and</strong> the phase 1b/2a trial <strong>of</strong> MOR103 in RA is meanwhile completed. Our S, G&A<br />

expenses also decreased by around 8% to 10.6 million €.<br />

In the first six months <strong>of</strong> 2012, the EBIT amounted to minus 1.9 million €, compared to 21.5<br />

million € in the first half <strong>of</strong> 2011. The net loss <strong>of</strong> 1 million € corresponded to a diluted loss per<br />

share <strong>of</strong> 4 Cents.<br />

Slide 11: Segment Reporting<br />

Let’s now have a closer look at our segment reporting. As in previous periods, nearly three<br />

quarters <strong>of</strong> total revenues arose from the therapeutic side <strong>of</strong> our business, with Partnered<br />

Discovery generating 23.4 million € in the first half <strong>of</strong> 2012, compared to 56.1 million € in the<br />

previous year.<br />

Revenues in the Proprietary Development segment amounted to 0.8 million €. Those<br />

revenues have been generated by our funded research activities for Novartis in connection<br />

with the two pre-development programs into which <strong>MorphoSys</strong> has the option to opt-in after<br />

the discovery phase.<br />

Looking at AbD Serotec, you can see that revenues slightly decreased to 8.8 million € in the<br />

first half <strong>of</strong> 2012, compared to 9.4 million € in the first six months <strong>of</strong> 2011. This decrease is a<br />

reflection <strong>of</strong> a weak second quarter, driven by an especially low dem<strong>and</strong> in the research<br />

market.<br />

Slide 12: Balance Sheet<br />

Let’s now take a look at the balance sheet. <strong>MorphoSys</strong>’s cash, securities <strong>and</strong> interestbearing<br />

assignable loans amounted to 133.5 million € at the end <strong>of</strong> the second quarter. Our<br />

<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 5 <strong>of</strong> 17


funds, together with the Company’s sound financial performance, are <strong>of</strong> great value for the<br />

company <strong>and</strong> our shareholders, especially in today’s market environment. As most <strong>of</strong> you<br />

know, our cash is reserved for selective strategic transactions, which strengthen our core<br />

business. The acquisition <strong>of</strong> Sloning on the technology side <strong>and</strong> the in-licensing <strong>of</strong> MOR208<br />

on the product side could act as role models for the kind <strong>of</strong> transactions we are looking to<br />

secure.<br />

Slide 13: Guidance 2012<br />

Before we open the call for your questions, we would like to reconfirm our financial guidance<br />

for 2012. With a number <strong>of</strong> commercial discussions currently ongoing we are confident to see<br />

an increased dynamic in our top-line results in the second half <strong>of</strong> the year compared to the<br />

first six months. As before, total group revenues are expected to amount to 75 – 80 million €<br />

this year. As previously explained, this guidance does not reflect a potential successful outlicensing<br />

<strong>of</strong> any <strong>of</strong> our proprietary programs, which could significantly increase revenues.<br />

Expenses for proprietary development activities will mainly include the clinical development<br />

<strong>of</strong> our most advanced drug c<strong>and</strong>idates as well as the development <strong>of</strong> new technologies <strong>and</strong><br />

are expected to be between 20 million € <strong>and</strong> 25 million €. For 2012, we anticipate an EBIT in<br />

the range <strong>of</strong> 1 million € to 5 million €.<br />

Ladies <strong>and</strong> Gentlemen, that concludes my review for the first six months <strong>of</strong> 2012, <strong>and</strong> I’ll now<br />

h<strong>and</strong> back to Mario for the Q&A session.<br />

Mario Brkulj, Senior Manager Corporate Communications & IR, <strong>MorphoSys</strong> AG<br />

Thank you. We will now open the call for your questions.<br />

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Questions & Answers<br />

Gunnar Romer, Deutsche Bank<br />

Good afternoon, everyone. Thanks for taking my question. First question is regarding the<br />

guidance outlook for the second half. You already mentioned that you're in ongoing<br />

discussions. I was just wondering to what extent you expect potentially higher revenues also<br />

in your partnered business excluding what is already ongoing? And, to what extent this really<br />

refers to Ylanthia?<br />

Then, secondly on the outlook for AbD, what are you seeing currently? Is there potential for<br />

improvement in the second half as well or do you think current trends would continue for the<br />

next couple <strong>of</strong> quarter? And the last question, you indicated that you've started two new<br />

programs but I didn't really get what these were. If you could repeat this, please.<br />

Dr. Simon Moroney, CEO <strong>of</strong> <strong>MorphoSys</strong> AG<br />

Sure, Gunnar, thanks for joining the call today. First <strong>of</strong> all, in terms <strong>of</strong> the guidance question,<br />

<strong>and</strong> where the revenue is coming from. We don't want to characterize that in detail, just let<br />

me say that as you know, we have a number <strong>of</strong> technologies, a number <strong>of</strong> existing<br />

partnerships. We're in a number <strong>of</strong> discussions with potential new partners. We have good<br />

visibility based on the status <strong>of</strong> some <strong>of</strong> those discussions <strong>and</strong> that visibility gives us the<br />

confidence to be able to confirm our guidance for the full year. But what we don't want to do<br />

at this stage is characterize with any precision about precisely what -how those<br />

collaborations or deals or partnerships may look, what technologies may or may not be<br />

involved <strong>and</strong> with whom they may be. But as I say, the visibility is sufficiently strong that<br />

we're happy to confirm our guidance for the full year.<br />

Regarding the question about AbD, as we mentioned during the presentation the research<br />

market is definitely weak. A lot <strong>of</strong> the scientists that are our customers who depend on grants<br />

from governments around the world, a lot <strong>of</strong> that grant funding has dried up to a large extent<br />

<strong>and</strong> the growth in that research market is close to zero, quite frankly at the moment. So - <strong>and</strong><br />

we don't expect that to change in the near term, certainly not before the end <strong>of</strong> the year.<br />

Nevertheless, we're confident that AbD will reach its targets, but the kinds <strong>of</strong> opportunities<br />

that we're looking at are rather larger deals with companies, commercial organizations, rather<br />

than selling antibodies to individual researchers. And as we mentioned, our increasing focus<br />

on bigger opportunities, diagnostics for example, helps us <strong>and</strong> will help AbD to reach its<br />

targets for the remainder <strong>of</strong> the year, rather than relying on that basic research business.<br />

Coming to your third question regarding the two new programs. Just to be very clear, these<br />

were two new program starts <strong>and</strong> we haven't, I believe, indicated where they came from, the<br />

origin <strong>of</strong> those programs, but you should have seen that they are new discovery programs,<br />

so they're coming in right at the front <strong>of</strong> the pipeline.<br />

Gunnar Romer<br />

Okay, thank you. But just with regard to the two new programs, that would mean that you<br />

have discontinued two as well?<br />

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Simon Moroney<br />

No, because the count at the last call, Q1, was 71.<br />

Gunnar Romer<br />

Right. Okay.<br />

Simon Moroney<br />

So, we added two now so that makes it 73 now.<br />

Gunnar Romer<br />

Okay. Then one final question on MOR103 <strong>and</strong> the upcoming data points. I mean you're<br />

already pretty precise in terms <strong>of</strong> timing, I was wondering whether this was just relating to the<br />

phase I/2 trial or whether we should expect subcutaneous data also in the second half <strong>of</strong><br />

September.<br />

Simon Moroney<br />

Yes, we haven't finalized the timing <strong>of</strong> those two announcements with precision, but we<br />

expect both sets <strong>of</strong> data to be available roughly around the same time <strong>and</strong> so precisely when<br />

we'll announce them we haven't yet finalized, but roughly around the same time.<br />

Gunnar Romer<br />

Okay, thank you.<br />

Daniel Wendorff, Commerzbank<br />

Good afternoon <strong>and</strong> thanks for taking my question, two if I may. Starting <strong>of</strong>f with your chart<br />

on page - on slide four, question from my side would be as you haven't specified the various<br />

partners for preclinical <strong>and</strong> discovery projects <strong>and</strong> aside from that I count six Novartis<br />

partnered programs as well as co-development programs, could you quantify the total<br />

number <strong>of</strong> programs you are working with or you have been working on for Novartis. That<br />

would be a helpful number for me.<br />

And second question would be on your investment guidance for proprietary R&D. Is it fair to<br />

assume that you would rather be in the lower half for 2012 than in the upper half <strong>of</strong> that<br />

guidance range? Any comment there would be helpful as well. Thank you very much.<br />

Simon Moroney, <strong>MorphoSys</strong> AG<br />

Okay, Daniel, thanks for the questions. I'll - let me take the first one <strong>and</strong> then Jens will take<br />

the second one. So in terms <strong>of</strong> the total number <strong>of</strong> Novartis programs, to tell you the truth, I<br />

don't have the precise number in mind, but I think it's fair to assume that its more than half <strong>of</strong><br />

the total number or around half, somewhere in that ballpark.<br />

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If you need a precise number, we may be able to get that to you, but as I say, the orientation<br />

it's around half approximately.<br />

Daniel Wendorff<br />

So maybe a quick question there, so half <strong>of</strong> the partner programs, or half <strong>of</strong> the 73 overall.<br />

Simon Moroney<br />

Half <strong>of</strong> the partnered, sorry.<br />

Daniel Wendorff<br />

Yes, okay.<br />

Simon Moroney<br />

30 odd, low 30 something like that.<br />

Daniel Wendorff<br />

Okay.<br />

Jens Holstein, CFO <strong>of</strong> <strong>MorphoSys</strong> AG<br />

And on the R&D expenses for proprietary, its - I mean we just reiterated our guidance for 20<br />

to 25 <strong>and</strong> we would like to keep it at that level. We haven't specified it nearer <strong>and</strong> I wouldn't<br />

like to do that at this point in time.<br />

Daniel Wendorff<br />

Yes, fair enough. Thank you.<br />

Gary Wa<strong>and</strong>ers, Nomura Securities<br />

Hi there. Excuse me. Just a question on the AbD Serotec revenue <strong>and</strong> the focus on<br />

diagnostics. There are already a number <strong>of</strong> anti-monoclonal - anti therapeutic monoclonal<br />

antibodies now available through AbD Serotec. Can you give us an idea <strong>of</strong> how much <strong>of</strong> the<br />

turnover <strong>of</strong> 8.8 was due to sales related to these sorts <strong>of</strong> programs? And what your sort <strong>of</strong><br />

goal long term might be, as a proportion?<br />

Simon Moroney<br />

Yes, Gary, I think it's safe to assume that the contribution is not substantial at this stage. The<br />

newly launched product which is just getting going. We do hope <strong>and</strong> expect them to pick up<br />

<strong>and</strong> the beauty <strong>of</strong> these kinds <strong>of</strong> products, <strong>of</strong> course is that those royalty streams that flow to<br />

us are pure pr<strong>of</strong>it <strong>and</strong> so the intention <strong>and</strong> the belief here is that over time as they - as those<br />

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products grow, they will also contribute to an increase in the underlying pr<strong>of</strong>it margin <strong>of</strong> the<br />

business <strong>and</strong> that's one <strong>of</strong> the reasons why we expect in the years to come that the pr<strong>of</strong>it<br />

margin for AbD can improve significantly beyond the current sort <strong>of</strong> midsingle digits net that<br />

we have at the moment into somewhere into the mid teens <strong>and</strong> if not into the 20% range. But<br />

its early days yet, these are br<strong>and</strong> new products, they're just getting going <strong>and</strong> the<br />

contribution is not substantial at this stage.<br />

Gary Wa<strong>and</strong>ers<br />

Okay, <strong>and</strong> if I might just quickly on MOR103, will you have the complete data analysis at that<br />

point when you release the report or will there be further analysis to conduct after that?<br />

Simon Moroney<br />

It will be a pretty complete package that we'll be able to announce in the second half <strong>of</strong><br />

September. So, it will be more than simply headline data.<br />

Gary Wa<strong>and</strong>ers<br />

Okay.<br />

Simon Moroney<br />

So we're taking the opportunity to really go through the data in detail <strong>and</strong> get a<br />

comprehensive <strong>and</strong> we hope meaningful package.<br />

Gary Wa<strong>and</strong>ers<br />

Okay, thanks very much.<br />

Elmar Kraus, DZ Bank<br />

Good afternoon, gentlemen, <strong>and</strong> thanks for taking my question. The first one with the<br />

EBITDA margin has just been answered so I'm left with just one more that's on the overall<br />

revenue line. Considering the fact that you had one milestone payment in the last quarter <strong>and</strong><br />

still, inverted commas, “only” an overall revenue <strong>of</strong> 16.5, is it fair to assume that you now<br />

have reached your baseline revenue quantity <strong>of</strong> let's say around 15 million. Is that fair to say?<br />

Thank you.<br />

Jens Holstein, CFO <strong>of</strong> <strong>MorphoSys</strong> AG<br />

Yes, <strong>and</strong> thanks for the question. Well just maybe to clarify the <strong>Q2</strong> figure was 16.9.<br />

Elmar Kraus<br />

Sorry.<br />

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Jens Holstein<br />

Yeah, no worries. As you know, I mean there are - the milestone payments are coming in<br />

special deals on technologies <strong>and</strong> so on they're also coming in. So there is a fluctuation. As<br />

you know, what's safe in terms <strong>of</strong> the top line is always what we get from Novartis for FTE<br />

funding as well as for the license fee <strong>and</strong> on top <strong>of</strong> that, there will be always millions on - for<br />

this sort <strong>of</strong> deals which have been mentioned by Simon before <strong>and</strong> which I just mentioned.<br />

So, I can't confirm what you're saying that it is a decision ballpark which like “on 15 million it’s<br />

safe”. There will be fluctuations in the future <strong>and</strong> certainly we are aiming that the numbers by<br />

quarter are higher than what you have just addressed as the number.<br />

Elmar Kraus<br />

Thank you.<br />

Thomas Schiessle, EQUI.TS<br />

Thomas Schiessle from EQUI.TS in Frankfurt. Hello gentlemen. I would like to ask two<br />

questions, one on Ylanthia. Simon could you - could you confirm whether there might be at<br />

least one deal in the current business year? A technology deal?<br />

And the other question is on the partners portfolio, the recent fluctuation <strong>of</strong> the number <strong>of</strong><br />

partnered projects is approximately between 65, some more, some less. Is this the run rate<br />

we shall assume for the future? So, you are working at some 60 projects in the future as<br />

well? Thank you for clarification.<br />

Simon Moroney, <strong>MorphoSys</strong> AG<br />

Thanks, Thomas. Nice to hear from you. Just in terms <strong>of</strong> the types <strong>of</strong> deals that we're going<br />

to be doing between now <strong>and</strong> year end, as we indicated. We're confident based on the<br />

technologies we have to enter deals, let me say plural, until year end. We anticipate that<br />

Ylanthia will be a component <strong>of</strong> the activities that we engage in before year end, but you<br />

should think in terms <strong>of</strong> kind <strong>of</strong> packages <strong>of</strong> technology as well. The Slonomics platform for<br />

example is an integral part <strong>of</strong> what we have to <strong>of</strong>fer today. We see it being used in<br />

conjunction with Ylanthia for example. So, we're really in the nice position <strong>of</strong> having a suite <strong>of</strong><br />

technologies if you like that we can <strong>of</strong>fer <strong>and</strong> its therefore difficult to think about how<br />

individual deals might look <strong>and</strong> we don't really want to get into detailed discussions <strong>of</strong> that at<br />

this stage, but all <strong>of</strong> the - all <strong>of</strong> the technologies that we've developed <strong>and</strong> that are available<br />

are a subject <strong>of</strong> those discussions that are currently ongoing.<br />

In terms <strong>of</strong> the partnered portfolio, the way we think about this is that the number <strong>of</strong> new<br />

starts we're always aiming at somewhere in the ballpark <strong>of</strong> 10 or so per year. What is difficult<br />

to predict is the attrition rate, how many ongoing programs fall out <strong>and</strong> at what time they fall<br />

out. That's a little bit hard to predict, it can go in waves. But we hope that the net effect<br />

overall is that the total number <strong>of</strong> programs increases. Okay, but again, given the<br />

unpredictability <strong>of</strong> attrition, it's hard to predict at what rate that total will increase, but we do<br />

<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 11 <strong>of</strong> 17


anticipate <strong>and</strong> expect <strong>and</strong> plan for a continuous increase in the number <strong>of</strong> - or a steady<br />

increase year on year in the number <strong>of</strong> programs that are actually started.<br />

Thomas Schiessle<br />

So the number <strong>of</strong> employees working on those projects will still be the same range.<br />

Simon Moroney<br />

To the extent that new deals come in, which require collaboration <strong>and</strong> support on our side<br />

then new employees may be necessary to do those. Just that currently the bulk <strong>of</strong> employees<br />

working on these partnered projects are assigned to Novartis, as you know, <strong>and</strong> that is<br />

essentially a steady state. So that number <strong>of</strong> FTEs is fixed <strong>and</strong> doesn't change <strong>and</strong> is based<br />

on the inflow <strong>of</strong> programs, targets that come to us from Novartis. But beyond that, new deals<br />

could mean new employees.<br />

Thomas Schiessle<br />

Okay, may I ask an additional question on AbD?<br />

Simon Moroney<br />

Please. Yes.<br />

Thomas Schiessle<br />

You emphasized that the research market is more <strong>of</strong> less down, so you switched to - luckily<br />

you switched to a more to diagnostics. How - what amount <strong>of</strong> investments in - you have to<br />

spend to be in a good position to run this business with diagnostic. Is there anything to spend<br />

in the near future or is this ongoing investment?<br />

Simon Moroney<br />

Yes, the investments aren't huge here. That's really the beauty <strong>of</strong> this business. Its - what<br />

we're doing is we're really taking advantage <strong>of</strong> preexisting expertise that we have around the<br />

HuCAL technology <strong>and</strong> the HuCAL - <strong>of</strong> course applying the HuCAL technology itself, which<br />

turns out to have certain genuine advantages in the diagnostic setting, in addition to its<br />

already established <strong>and</strong> known advantages <strong>and</strong> therapeutics. And amongst these<br />

advantages is the ability to make anti idiotypic antibodies, which is the subject <strong>of</strong> all these<br />

products that we talked about during the presentation.<br />

So to - actually we're - <strong>and</strong> AbD is kind <strong>of</strong> blessed with having this existing expertise <strong>and</strong><br />

technology platform which is now simply being applied in a new area. So, it's a relatively easy<br />

step for us to take to move into this diagnostic space.<br />

Thomas Schiessle<br />

Okay, thanks for the information. Thank you.<br />

<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 12 <strong>of</strong> 17


Daniel Wendorff, Commerzbank<br />

Thanks for taking my follow up for question <strong>and</strong> that is also related to the potential<br />

partnerships or technology deals you might find <strong>and</strong> do in the second half <strong>of</strong> 2012. Is it fair to<br />

assume that it's also an - well, how shall I say that, a possibility <strong>and</strong> that might also be a<br />

HuCAL partnership in the area <strong>of</strong> infectious diseases? Or is that not something which you<br />

would regard as likely? Thank you.<br />

Simon Moroney, <strong>MorphoSys</strong> AG<br />

Could be.<br />

Daniel Wendorff<br />

Okay.<br />

Simon Moroney<br />

That's - you've rightly spotted <strong>of</strong> course that we have freedom to - full freedom to operate with<br />

HuCAL in the infectious disease space <strong>and</strong> amongst the list <strong>of</strong> discussions, negotiations <strong>and</strong><br />

things that are ongoing that is included.<br />

Daniel Wendorff<br />

Okay, so you have discussions in that area with potential partners.<br />

Simon Moroney<br />

Yes.<br />

Daniel Wendorff<br />

Okay, thanks.<br />

Sachin Soni, Kempen & Co.<br />

Good afternoon everyone. I have three questions. First is regarding the current status <strong>of</strong><br />

technology platform, you have upgraded the platform substantially after certain acquisitions,<br />

do you think there is still more room for improvements if yes, what direction would you go in<br />

improving the current technology platform.<br />

Then second is, regarding out licensing strategy. Is it correct to assume that you're internal<br />

biases towards out licensing <strong>and</strong> asset after pro<strong>of</strong> <strong>of</strong> concept or would you consider your<br />

proprietary assets to be out licensed earlier than that as well?<br />

<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 13 <strong>of</strong> 17


And third question, the potential deal on technology platform which we have been talking, am<br />

I underst<strong>and</strong>ing correctly to assume that this deal is a part <strong>of</strong> guidance already in revenues?<br />

Thank you.<br />

Simon Moroney, <strong>MorphoSys</strong><br />

Okay, thanks Sachin. Let me start with the technology platform. So, first <strong>of</strong> all, it cannot be<br />

improved further probably. We think that there are ways in which what we have can be<br />

exp<strong>and</strong>ed <strong>and</strong> proved, made more useful <strong>and</strong> if you think about it, it's really around the<br />

potential application for antibodies. The challenges at the moment are what types <strong>of</strong> targets<br />

can you hit. There are definitely classes <strong>of</strong> targets at the moment that are difficult to hit,<br />

which it would be great if you could go after <strong>and</strong> I think GPCRs, ion channels <strong>and</strong> so on, this<br />

is well known in the community. Could you get antibodies into cells for example <strong>and</strong> thereby<br />

access a whole new class <strong>of</strong> targets? Could you administer antibodies differently than<br />

intravenously or subcutaneously? So, it's a fantastic class <strong>of</strong> drugs, but there's definitely<br />

scope to improve on it further <strong>and</strong> these are some <strong>of</strong> the challenges - just some <strong>of</strong> the<br />

challenges that we are thinking about at the moment.<br />

While we're on the subject <strong>of</strong> technologies, I'll come to your third question which is are the<br />

types <strong>of</strong> deals that we referred to included in the guidance for the remainder <strong>of</strong> the year, the<br />

answer is definitely a yes to that one.<br />

And then finally, coming back to your second question in terms <strong>of</strong> out licensing, the intention<br />

for MOR103 is certainly not to take that forward in an indication like rheumatoid arthritis on<br />

our own <strong>and</strong> we feel that given good pro<strong>of</strong> <strong>of</strong> concept data that's an ideal time to find a good<br />

partner for that program. For the remaining programs, MOR208 <strong>and</strong> MOR202 for example,<br />

the current plan is to go to pro<strong>of</strong> <strong>of</strong> concept, because we feel that that's where we can<br />

establish the greatest value for those two programs <strong>and</strong> not to partner them earlier than that.<br />

That is the plan that we have for those two remaining programs.<br />

Sachin Soni<br />

Great, thank you.<br />

Gary Wa<strong>and</strong>ers, Nomura Securities<br />

Hi there, just to follow up on the platform discussion. Has there been any noticeable shift in<br />

the collaborative efforts with Novartis following the internalization <strong>of</strong> the HuCAL platform? It’s<br />

kind <strong>of</strong> the first part <strong>of</strong> that. And what is their stance vis a vis Ylanthia <strong>and</strong> development,<br />

discovery programs. Thanks.<br />

Simon Moroney, <strong>MorphoSys</strong> AG<br />

So, thanks Gary. Regarding the first part <strong>of</strong> that question, it was always part <strong>of</strong> the deal that<br />

they would internalize the HuCAL platform <strong>and</strong> it was also always part <strong>of</strong> the deal that there<br />

would be a constant, a steady state number <strong>of</strong> programs that would be pursued here. And<br />

that continues to be the case. So, the fact that they've internalized the HuCAL platform<br />

<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 14 <strong>of</strong> 17


doesn't really have any bearing on the collaboration as such because there's a constant<br />

amount <strong>of</strong> work going on.<br />

Gary Wa<strong>and</strong>ers<br />

Okay.<br />

Simon Moroney<br />

New targets come in as old targets are h<strong>and</strong>ed back or targets that have been worked up are<br />

h<strong>and</strong>ed back.<br />

With regards to Ylanthia, our view is that Ylanthia is a more <strong>and</strong> will be a more powerful<br />

technology than HuCAL. We believe therefore that it's the technology <strong>of</strong> choice for all<br />

therapeutic applications. We therefore absolutely want to have that as a part <strong>of</strong> our<br />

collaboration with Novartis <strong>and</strong> we're currently working closely with Novartis to figure out how<br />

that will precisely work <strong>and</strong> at what stage it should be brought into the collaboration, but that's<br />

absolutely the joint intention <strong>of</strong> the two parties that we together use the Ylanthia platform to<br />

make the next generation <strong>of</strong> therapeutic antibodies.<br />

Gary Wa<strong>and</strong>ers<br />

Okay, thanks.<br />

Gunnar Romer, Deutsche Bank<br />

Thanks for taking my follow up. This would be probably a question for Jens. I was wondering<br />

whether you could give us an idea <strong>of</strong> why the uptake in SG&A, what's behind that <strong>and</strong> then<br />

also with regard to partnered R&D, I noticed, was a little bit higher in <strong>Q2</strong>. Just was curious<br />

about whether there's a relationship also between partnered R&D <strong>and</strong> SG&A here?<br />

Jens Holstein, <strong>MorphoSys</strong> AG<br />

First, thanks Gunnar for the question. First maybe coming to the second question which you<br />

have addressed in the partner business. In absolute terms you're right, the amount went up<br />

but please be reminded that there is also - there are also some technology development<br />

expenses in there <strong>and</strong> this is certainly influencing the figures <strong>and</strong> here, I think we also see<br />

fluctuations. So therefore, I think in terms <strong>of</strong> what we have seen in the first half <strong>of</strong> last year as<br />

spending <strong>and</strong> in the first half <strong>of</strong> this year as spending for the partner business. You run in the<br />

sort <strong>of</strong> range <strong>of</strong> 9 to 11 million for that segment which we run <strong>and</strong> I think something like this is<br />

pretty much stable for each half year. So, I mean if you think <strong>of</strong> your model, I think something<br />

like this ballpark is pretty much okay.<br />

In terms <strong>of</strong> the SG&A expenses, I mean you have seen that we'll have in comparison to the<br />

first - so the second three months for the second quarter <strong>of</strong> last year that we have reduced<br />

our SG&A expenses <strong>and</strong> as such, I think we assumed that also in terms <strong>of</strong> the full year when<br />

we are not too far away <strong>of</strong> what we have seen for the first half year in terms <strong>of</strong> what we can<br />

<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 15 <strong>of</strong> 17


expect <strong>of</strong> total expenses. I mean there is some specifics always, some consultancy expenses<br />

which cause some deviation, but in that sort <strong>of</strong> ballpark, I think assumptions are well placed.<br />

Gunnar Romer<br />

Okay, that's helpful, but there's no significant let's say kind <strong>of</strong> upfront investments for<br />

upcoming technology deals that might go away in the second half.<br />

Jens Holstein<br />

Well, most likely those technology deals will be CapEx for us.<br />

Gunnar Romer<br />

Right. Okay.<br />

Jens Holstein<br />

Yes, <strong>and</strong> as such, we would book them accordingly.<br />

Gunnar Romer<br />

Okay, thank you.<br />

<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 16 <strong>of</strong> 17


Dr. Simon E. Moroney, CEO, <strong>MorphoSys</strong> AG<br />

To conclude the call, I’d like to remind you <strong>of</strong> the main points to take away. First, the<br />

Company’s greatest source <strong>of</strong> value, its drug pipeline, continues to develop well. We are on<br />

track to report clinical data from our two most advanced programs MOR103 <strong>and</strong> MOR208<br />

later this year as planned. Second, our partnered pipeline continues to grow <strong>and</strong> to mature<br />

with the transition <strong>of</strong> gantenerumab to a potentially pivotal trial for Alzheimer’s disease being<br />

the main highlight. And finally, we’re happy to re-confirm that we are on track to hit our<br />

financial targets for the year.<br />

Mario Brkulj, Senior Manager Corporate Communications & IR, <strong>MorphoSys</strong> AG<br />

That concludes the call. If any <strong>of</strong> you would like to follow up, we are in the <strong>of</strong>fice for the<br />

remainder <strong>of</strong> the day. Thank you for your participation on the call <strong>and</strong> goodbye.<br />

HuCAL ® , HuCAL GOLD ® , HuCAL PLATINUM ® , Ylanthia ® , CysDisplay ® , RapMAT ® <strong>and</strong><br />

arYla ® are registered trademarks <strong>of</strong> <strong>MorphoSys</strong> AG.<br />

Slonomics ® is a registered trademark <strong>of</strong> Sloning BioTechnology GmbH, a subsidiary <strong>of</strong><br />

<strong>MorphoSys</strong> AG.<br />

<strong>MorphoSys</strong> AG <strong>Q2</strong> 2012 <strong>Conference</strong> <strong>Call</strong> Manuscript Page 17 <strong>of</strong> 17

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