Curriculum vitae

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Composition of Günther Group Post Docs Physicians Students 4 PhDs (biology, chemistry, pharmacy), 1 MD 3 (2 interns, 1 senior physician) 5 PhD students (International Graduate Program) 10 medical students Technicians 4 Management 1 personal assistant / project manager, 1 secretary Method Competence reflecting the translational research approach Cell biology: isolation and culture of lung endothelial and epithelial cells and fibroblasts; laserassisted cell picking; semiquantitative and quantitative RT-PCR; transfection of various cell types with siRNA and gene vectors; assessment of proliferation, apoptosis, cell cycle, cellular transport processes, Biochemistry: HPTLC; HPTLC; GC; FPLC; SDS-PAGE and Western Blotting; ELISA; enzyme activity assays including active site titration; ligand binding assays; immunoprecipitation; proteomic profiling (conventional, DIGE) Molecular Biology: Transcriptome profiling of laser dissected and preamplified tissues; vector cloning; reporter gene assays; gene sequencing; northern/southern blotting; EMSA. Animal Experimentation: Expertise in generation, housing and breeding of transgenic mice; comprehensive description of lung phenotyp by assessment of physiological variables (lung compliance, gas exchange), radiological (volume or high resoluted CT) or histological changes (digital slide scanning and subsequent fully automatized morphometric analysis (Axiovision software Zeiss), surrogate parameters of fibrosis (soluble collagen, hydroxyproline), immunohistochemistry with quantitative evaluation. Established Animal Models of Lung Fibrosis: Inflammatory: Bleomycin – induced lung fibrosis Non-inflammatory, short term: Amiodarone - or pepstatin-induced lung fibrosis Non-inflammatory, long term: SP-C KO, HPS 1/2, Established other Animal Models: Model of ventilator-induced lung injury in rats Acute respiratory failure/ARDS through repetitive lavage (rabbits) or LPS (mice) Bacterial pneumonia models (klebsiella, pneumococci, pseudomonas) in mice Microbiological / immunological techniques: Quantitative bacterial cultures; microbial clearance studies in vivo, antimicrobial activity assays Clinical: Conductance of several clinical trials in the field of ARDS, asthma, pneumonia and ILD, mostly at the level of steering committee member in pharmaceutically sponsored trials or in own (investigator) driven studies; excellent evaluation in all audits from health authorities or sponsors in view of quality of conducted clinical research and adherence to GCP; regular performance of interdisciplinary conferences for diagnosis of ILD; outpatient clinic with currently > 1000 patients per year
Selected scientific aims - areas of expertise 1) Regulation of alveolar surface tension under conditions of acute respiratory failure and chronic interstitial lung disease 2) Regulation of intracellular transport and lysosomal processing of pulmonary surfactant in alveolar type II cells under physiological and pathophysiological conditions 3) Interdependence of defective processing of surfactant proteins, development of ER stress, apoptosis and development of lung fibrosis 4) Disclosure of pro-apoptotic signalling in alveolar type II cells and their role in diffuse parenchymal lung diseases 5) Deciphering the relative importance and interaction of the intrinsic and the extrinsic coagulation system within the vasculature and inside the alveolus 6) Fibrinolytic and epithelial-protective effects of different plasminogen activators – development of new strategies for correction of antifibrinolytic burden in ARDS and IPF 7) Alveolar innate immune defense system and susceptibility to recurrent infection in chronic lung diseases – therapeutic prospects 8) Role of urokinase and vasculogenesis in primary tumor growth of lung cancer 9) Oxidative stress and antioxidative capacities in the alveolar epithelium and their role in acute inflammatory and chronic interstitial lung diseases 10) Differential regulation of MMPs and TIMPs in interstitial lung diseases – special role of MMP13 11) Cellular consequences of selective overexpression of single ER-stress signalling molecules in vitro and in vivo 12) αvβ6 integrins, TGF-b activation and smad 7 signalling in ILD 13) New strategies for inhalative application of pharmaceuticals in mice and men 14) Deciphering new surrogate parameters of disease progression in blood, BALF and exhaled breath condensate in IPF, NSIP and ILD due to collagen/vascular diseases 15) Classification of fibrotic and cellular NSIP patients according to BALF cell differential, HRCT and histopathology 16) Role of HGF in epithelial protection in IPF and ARDS 17) Notch signalling in the fibrotic lung and it´s role in local stem cell proliferation and differentiation 18) Mutual interplay between respiratory infections and development of lung fibrosis 19) Development of novel dual Xa/IIa antagonists for local alveolar anticoagulation 20) Disclosure of new candidate genes in familiar forms of IPF 21) Clinical development of a selective alveolar anticoagulation in IPF 22) Clinical development of strategies for selective alveolar application of antiapoptotic drugs
Page 1 and 2: Curriculum vitae Andreas Günther,
Page 3: Reviewer Responsibilities American

Curriculum vitae

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