MOR103 Presentation - MorphoSys

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Most Common TEAEs Subjects with TEAEs by Preferred Term Adverse Event Preferred Term Subj. with at least one TEAE Placebo N=27 Total active N=69 0.3 mg/kg N=24 MOR 103 1.0 mg/kg N=22 1.5 mg/kg N=23 Placebo vs Total Active (Fisher‘s Exact Test) 44.4% (n=12) 60.9% (n=42) 54.2% (n=13) 63.6% (n=14) 65.2% (n=15) 0.1733 related 25.9% (n=7) 14.5% (n=10) 12.5% (n=3) 13.6% (n=3) 17.4% (n=4) 0.2357 Nasopharyngitis 11.1% (n=3) 13.0% (n=9) 4.2% (n=1) 31.8% (n=7) 4.3% (n=1) >0.9999 Rheumatoid Arthritis worsening related 7.4% (n=2) 1.4% (n=1) 4.2% (n=1) 0.0% (n=0) 0.0% (n=0) 0.1900 0.0% (n=0) 13.0% (n=9) 12.5% (n=3) 18.2% (n=4) 8.7% (n=2) 0.0574 related 0.0% (n=0) 1 (1.4%) 0.0% (n=0) 4.5% (n=1) 0.0% (n=0) >0.9999 Fatigue 3.7% (n=1) 8.7% (n=6) 4.2% (n=1) 18.2% (n=4) 4.3% (n=1) 0.6690 related 0.0% (n=0) 4.3% (n=3) 4.2% (n=1) 4.5% (n=1) 4.3% (n=1) 0.5567 Hypertension 3.7% (n=1) 7.2% (n=5) 4.2% (n=1) 9.1% (n=2) 8.7% (n=2) >0.9999 related 0.0% (n=0) 1.4% (n=1) 0.0% (n=0) 4.5% (n=1) 0.0% (n=0) >0.9999 Cough 0.0% (n=0) 4.3% (n=3) 4.2% (n=1) 0.0% (n=0) 8.7% (n=2) 0.5567 related 0.0% (n=0) 0.0% (n=0) 0.0% (n=0) 0.0% (n=0) 0.0% (n=0) >0.9999 ACR/ARHP 2012 – Washington DC – November 10-14, 2012
ACR Response at Week 4 Percentage of Patients achieving ACR 20, ACR 50, ACR 70 Proportion of Responders [%] ACR/ARHP 2012 – Washington DC – November 10-14, 2012
Page 1 and 2: Abstract-Number: L11 First in Patie
Page 3 and 4: Disclosures • F. Behrens, M. Oste
Page 5 and 6: Anti-GM-CSF Monoclonal Antibody (MO
Page 7 and 8: Study design 0.3 mg/kg MOR103 (n=25
Page 9 and 10: Baseline Disease Characteristics Ch
Page 11: Patient Disposition Placebo (n=27)
Page 15 and 16: EULAR Response at Week 4 Percentage
Page 17 and 18: Change of Synovitis by MRI Analysis
Page 19 and 20: Acknowledgements Investigators �
Page 21 and 22: Geographic Distribution of Patients
Page 23: DAS28 Response to Treatment MOR103

MOR103 Presentation - MorphoSys

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