Chemwatch Australian MSDS 22-5369 - Dentsply

DENTSPLY ORAQIX
Chemwatch Independent Material Safety Data Sheet
Issue Date: 25-Nov-2009 CHEMWATCH 22-5369
C9317TC
Version No:2.0
CD 2010/2 Page 1 of 6
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
DENTSPLY ORAQIX
PRODUCT USE
Indicated for adults who require localized anesthesia in periodontal pockets during scaling and / or root planning.
SUPPLIER
Company: DENTSPLY (AUSTRALIA) PTY LTD
Address:
11 - 21 Gilby Road
Mount Waverley
VIC 3149
AUSTRALIA
Telephone: 1300 55 29 29
Emergency Tel: 1300 55 29 29 (Hours of operation:
Monday - Friday 9:00 am - 5:00 pm EST; General
information only)
Fax: +61 3 9538 8260
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. NON-DANGEROUS GOODS. According to NOHSC Criteria, and ADG Code.
POISONS SCHEDULE
S2
RISK
SAFETY
■ Limited evidence of a carcinogenic
■ Do not breathe gas/fumes/vapour/spray.
effect.
■ May cause SENSITISATION by skin
■ Avoid contact with eyes.
contact.
■ Cumulative effects may result
■ Wear suitable protective clothing.
following exposure*.
■ May produce discomfort of the eyes,
■ To clean the floor and all objects contaminated by this
respiratory tract and skin*.
material use water.
* (limited evidence). ■ Keep away from food drink and animal feeding stuffs.
■ In case of contact with eyes rinse with plenty of water
and contact Doctor or Poisons Information Centre.
■ If swallowed IMMEDIATELY contact Doctor or Poisons
Information Centre. (show this container or label).
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
lignocaine 137-58-6 2.5
prilocaine 721-50-6 2.5
water 7732-18-5 notspec
Section 4 - FIRST AID MEASURES
SWALLOWED
• Immediately give a glass of water.
• First aid is not generally required. If in doubt, contact a Poisons Information Centre or a doctor.
EYE
■ If this product comes in contact with the eyes:
• Wash out immediately with fresh running water.
• Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper and lower
lids.
• Seek medical attention without delay; if pain persists or recurs seek medical attention.
• Removal of contact lenses after an eye injury should only be undertaken by skilled personnel.
continued...

DENTSPLY ORAQIX
Chemwatch Independent Material Safety Data Sheet
Issue Date: 25-Nov-2009 CHEMWATCH 22-5369
C9317TC
Version No:2.0
CD 2010/2 Page 2 of 6
Section 4 - FIRST AID MEASURES
SKIN
■ If skin contact occurs:
• Immediately remove all contaminated clothing, including footwear.
• Flush skin and hair with running water (and soap if available).
• Seek medical attention in event of irritation.
INHALED
• If fumes or combustion products are inhaled remove from contaminated area.
• Lay patient down. Keep warm and rested.
• Prostheses such as false teeth, which may block airway, should be removed, where possible, prior to initiating first aid procedures.
• Apply artificial respiration if not breathing, preferably with a demand valve resuscitator, bag-valve mask device, or pocket mask as trained.
Perform CPR if necessary.
NOTES TO PHYSICIAN
■ When systemic reaction to local anaesthetic occurs, steps should be taken to maintain circulation and respiration and control convulsions. A clear
airway should be established and oxygen given together with assisted ventilation if necessary.
Metabolism of amide-type anaesthetics occurs in the liver and in some cases in the kidney. Because these undergo extensive and rapid hepatic
metabolism, only about 1/3 of an oral dose reaches the systemic circulation.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
• There is no restriction on the type of extinguisher which may be used.
• Use extinguishing media suitable for surrounding area.
FIRE FIGHTING
• Alert Fire Brigade and tell them location and nature of hazard.
• Wear full body protective clothing with breathing apparatus.
• Prevent, by any means available, spillage from entering drains or water course.
• Use water delivered as a fine spray to control fire and cool adjacent area.
FIRE/EXPLOSION HAZARD
• The material is not readily combustible under normal conditions.
• However, it will break down under fire conditions and the organic component may burn.
• Not considered to be a significant fire risk.
• Heat may cause expansion or decomposition with violent rupture of containers.
Combustion products include: carbon dioxide (CO2), carbon monoxide (CO), hydrogen chloride, phosgene, nitrogen oxides (NOx), other pyrolysis products
typical of burning organic material.
May emit poisonous fumes.
May emit corrosive fumes.
FIRE INCOMPATIBILITY
• Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine bleaches, pool chlorine etc. as ignition may result.
HAZCHEM
None
PERSONAL PROTECTION
Glasses:
Chemical goggles.
Respirator:
Particulate
Section 6 - ACCIDENTAL RELEASE MEASURES
MINOR SPILLS
• Remove all ignition sources.
• Clean up all spills immediately.
• Avoid breathing vapours and contact with skin and eyes.
• Control personal contact by using protective equipment.
MAJOR SPILLS
■ Moderate hazard.
• Clear area of personnel and move upwind.
• Alert Fire Brigade and tell them location and nature of hazard.
• Wear breathing apparatus plus protective gloves.
• Prevent, by any means available, spillage from entering drains or water course.
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
continued...

DENTSPLY ORAQIX
Chemwatch Independent Material Safety Data Sheet
Issue Date: 25-Nov-2009 CHEMWATCH 22-5369
C9317TC
Version No:2.0
CD 2010/2 Page 3 of 6
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
• DO NOT allow clothing wet with material to stay in contact with skin.
• Avoid all personal contact, including inhalation.
• Wear protective clothing when risk of exposure occurs.
• Use in a well-ventilated area.
• Prevent concentration in hollows and sumps.
SUITABLE CONTAINER
• Packaging as recommended by manufacturer.
STORAGE INCOMPATIBILITY
• Avoid storage with reducing agents.
STORAGE REQUIREMENTS
• Store in original containers.
• Keep containers securely sealed.
• No smoking, naked lights or ignition sources.
• Store in a cool, dry, well-ventilated area.
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
The following materials had no OELs on our records
• lignocaine: CAS:137- 58- 6
• prilocaine: CAS:721- 50- 6
• water: CAS:7732- 18- 5
PERSONAL PROTECTION
RESPIRATOR
Particulate
EYE
• Safety glasses with side shields.
• Chemical goggles.
• Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants. A written policy document, describing the
wearing of lens or restrictions on use, should be created for each workplace or task. This should include a review of lens absorption and
adsorption for the class of chemicals in use and an account of injury experience. Medical and first-aid personnel should be trained in their
removal and suitable equipment should be readily available. In the event of chemical exposure, begin eye irrigation immediately and remove contact
lens as soon as practicable. Lens should be removed at the first signs of eye redness or irritation - lens should be removed in a clean environment
only after workers have washed hands thoroughly. [CDC NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
■ NOTE:
• The material may produce skin sensitisation in predisposed individuals. Care must be taken, when removing gloves and other protective equipment, to
avoid all possible skin contact.
• Contaminated leather items, such as shoes, belts and watch-bands should be removed and destroyed.
• Impervious gloves.
OTHER
• Overalls.
• P.V.C. apron.
• Barrier cream.
• Skin cleansing cream.
■ None under normal operating conditions.
ENGINEERING CONTROLS
■ Local exhaust ventilation usually required. If risk of overexposure exists, wear approved respirator.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Clear odourless liquid; mixes with water.
PHYSICAL PROPERTIES
Liquid.
continued...

DENTSPLY ORAQIX
Chemwatch Independent Material Safety Data Sheet
Issue Date: 25-Nov-2009 CHEMWATCH 22-5369
C9317TC
Version No:2.0
CD 2010/2 Page 4 of 6
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Mixes with water.
State Liquid Molecular Weight Not Available
Melting Range (°C) Not Available Viscosity Not Available
Boiling Range (°C) Not Available Solubility in water (g/L) M iscible
Flash Point (°C) Not Available pH (1% solution) Not Availabl e
Decomposition Temp (°C) Not Available pH (as supplied) 3.3- 5.5
Autoignition Temp (°C) Not Available Vapour Pressure (kPa) Not Available
Upper Explosive Limit (%) Not Available Specific Gravity (water=1) 1.0
Lower Explosive Limit (%) Not Available Relative Vapour Density Not Available
(air=1)
Volatile Component (%vol) Not Available Evaporation Rate Not Available
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
• Presence of incompatible materials.
• Product is considered stable.
• Hazardous polymerisation will not occur.
For incompatible materials - refer to Section 7 - Handling and Storage.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
■ May produce discomfort of the eyes, respiratory
tract and skin*.
■ * (limited evidence).
CHRONIC HEALTH EFFECTS
■ May cause SENSITISATION by skin contact.
■ Limited evidence of a carcinogenic
effect.
■ Cumulative effects may result following
exposure*.
■ * (limited evidence).
TOXICITY AND IRRITATION
PRILOCAINE:
LIGNOCAINE:
■ unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
■ unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
■ Contact allergies quickly manifest themselves as contact eczema, more rarely as urticaria or Quincke's oedema. The pathogenesis of contact eczema
involves a cell-mediated (T lymphocytes) immune reaction of the delayed type.
Asthma-like symptoms may continue for months or even years after exposure to the material ceases. This may be due to a non-allergenic condition known
as reactive airways dysfunction syndrome (RADS) which can occur following exposure to high levels of highly irritating compound.
LIGNOCAINE:
TOXICITY
Oral (rat) LD50: 317 mg/kg
Subcutaneous (rat) LD50: 335 mg/kg
Intravenous (Human) TDLo: 16 mg/kg
Intravenous (Human) TDLo: 23 mg/kg
Oral (Mouse) LD50: 220 mg/kg
Intraperitoneal (Mouse) LD50: 102 mg/kg
Subcutaneous (Mouse) LD50: 238 mg/kg
Oral (Human) TDLo: 39 mg/kg
Oral (Human) TDLo: 300 mg/kg
Intraperitoneal (Rat) LD50: 133 mg/kg
Intravenous (Rat) LD50: 18 mg/kg
Intravenous (Rabbit) LD: 41 mg/kg
Subcutaneous (Guinea pig) LD50: 120 mg/kg
Intravenous (Guinea pig) LD: 65 mg/kg
Dermal (Rabbit) TDLo: 0.024 mg/kg
Intravenous (Mouse) LD50: 39.4 mg/kg
IRRITATION
Nil Reported
PRILOCAINE:
TOXICITY
Intraperitoneal (rat) LD50: 148 mg/kg
Subcutaneous (rat) LD50: 790 mg/kg
Intravenous (rat) LD50: 56.6 mg/kg
Intraperitoneal (mouse) LD50: 30 mg/kg
IRRITATION
continued...

DENTSPLY ORAQIX
Chemwatch Independent Material Safety Data Sheet
Issue Date: 25-Nov-2009 CHEMWATCH 22-5369
C9317TC
Version No:2.0
CD 2010/2 Page 5 of 6
Section 11 - TOXICOLOGICAL INFORMATION
Subcutaneous (mouse) LD50: 632 mg/kg
Intravenous (mouse) LD50: 55 mg/kg
Intravenous (rabbit) LD50: 18 mg/kg
Intratracheal (rabbit) LD50: 65 mg/kg
■ Contact allergies quickly manifest themselves as contact eczema, more rarely as urticaria or Quincke's oedema. The pathogenesis of contact eczema
involves a cell-mediated (T lymphocytes) immune reaction of the delayed type.
for prilocaine hydrochloride:
Parenteral (man) LDLo: 12.43 mg/kg/1h - I Nil reported
Altered sleep-time, convulsions recorded.
CARCINOGEN
Anaesthetics, International Agency for Research on Cancer Group 3
volatile
(IARC) - Agents Reviewed by the IARC
Monographs
No data
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity
Ingredient Persistence: Persistence: Air Bioaccumulation Mobility
Water/Soil
lignocaine HIGH LOW MED
prilocaine HIGH LOW MED
water LOW LOW HIGH
Section 13 - DISPOSAL CONSIDERATIONS
• Containers may still present a chemical hazard/ danger when empty.
• Return to supplier for reuse/ recycling if possible.
Otherwise:
• If container can not be cleaned sufficiently well to ensure that residuals do not remain or if the container cannot be used to store the same
product, then puncture containers, to prevent re-use, and bury at an authorised landfill.
• Where possible retain label warnings and MSDS and observe all notices pertaining to the product.
Legislation addressing waste disposal requirements may differ by country, state and/ or territory. Each user must refer to laws operating in their
area.
A Hierarchy of Controls seems to be common - the user should investigate:
• Reduction.
Consult State Land Waste Management Authority for disposal.
Section 14 - TRANSPORTATION INFORMATION
HAZCHEM:
None (ADG7)
NOT REGULATED FOR TRANSPORT OF DANGEROUS GOODS: ADG7, UN, IATA, IMDG
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE
S2
REGULATIONS
Regulations for ingredients
lignocaine (CAS: 137-58-6) is found on the following regulatory lists;
"Australia Inventory of Chemical Substances (AICS)"
prilocaine (CAS: 721-50-6) is found on the following regulatory lists;
"Australia Inventory of Chemical Substances (AICS)"
TAP WATER (CAS: 7732-18-5) is found on the following regulatory lists;
"Australia Inventory of Chemical Substances (AICS)","IMO IBC Code Chapter 18: List of products to which the Code does not apply","OECD Representative
List of High Production Volume (HPV) Chemicals"
continued...

DENTSPLY ORAQIX
Chemwatch Independent Material Safety Data Sheet
Issue Date: 25-Nov-2009 CHEMWATCH 22-5369
C9317TC
Version No:2.0
CD 2010/2 Page 6 of 6
Section 15 - REGULATORY INFORMATION
No data for Dentsply Oraqix (CW: 22-5369)
Section 16 - OTHER INFORMATION
Denmark Advisory list for selfclassification of dangerous substances
Substance CAS Suggested codes
lignocaine 137- 58- 6 Xn Carc3; R40
prilocaine 721- 50- 6 Xn Carc3; R40
■ Classification of the preparation and its individual components has drawn on official and authoritative sources as well as independent review by
the Chemwatch Classification committee using available literature references.
A list of reference resources used to assist the committee may be found at:
www.chemwatch.net/references.
■ The (M)SDS is a Hazard Communication tool and should be used to assist in the Risk Assessment. Many factors determine whether the reported Hazards
are Risks in the workplace or other settings.
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written
permission from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 25-Nov-2009
Print Date: 8-Jul-2010
This is the end of the MSDS.