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EECS News Final 1.30.indd - Electrical Engineering and Computer ...

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“The breadth of KU research<br />

provided me with in-house<br />

collaborators for the project,<br />

which streamlines the<br />

development of a two-photon<br />

microscopy system,” says<br />

Hui. “There is a great need for<br />

accessible biological imaging<br />

tools. TP-FLEX, which will<br />

be the size of a briefcase, will<br />

enable two-photon microscopy<br />

to become available to those<br />

outside large research centers.”<br />

<strong>EECS</strong> Ph.D. student Peter Adany adjusts a spectrum analyzer during testing<br />

of the optical fiber, the yellow cable. Adany observes how the fiber reacts<br />

in different situations <strong>and</strong> then creates computer simulation models to<br />

predict future behavior.<br />

The KU system will permit<br />

the simultaneous monitoring<br />

of different biochemical<br />

functions through multicolor<br />

labeling. With bioflourescent<br />

markers attached to specific<br />

proteins, various protein <strong>and</strong><br />

molecular configurations can<br />

be distinguished <strong>and</strong> observed.<br />

Thus, scientists can observe<br />

multiple cellular events at the<br />

same time.<br />

<strong>EECS</strong> researchers are<br />

collaborating with investigators<br />

from KU’s Department of<br />

Chemistry <strong>and</strong> the KU Medical<br />

Center on the “Portable <strong>and</strong><br />

Wavelength-Tunable Two-<br />

Photon Microscopy” project.<br />

The lower cost <strong>and</strong> portability<br />

of TP-FLEX will enable greater<br />

accessibility for a wide range<br />

of biological, chemical, <strong>and</strong><br />

analytical applications. <br />

The fiber turns fluorescent as light travels through it.<br />

By underst<strong>and</strong>ing <strong>and</strong> controlling the generation of<br />

optical pulses, researchers can produce 3D images of<br />

living cells at greater depths <strong>and</strong> higher resolutions.<br />

29

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