Curriculum vitae - Isped

Curriculum vitae
Linda Wittkop, MD
Inserm U897 Centre of Epidemiology and Biostatistics
ISPED Bordeaux School of Public Health
University of Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
Tel : +33(0)5 57 57 95 76
Fax : +33(0)5 56 24 00 81
E-mail: linda.wittkop@isped.u-bordeaux2.fr
Education
Since 09/2007 PhD Student, Inserm U897 Centre for Epidemiology and Biostatistics,
University of Bordeaux 2, France financed by NEAT (European AIDS
Treatment Network). Supervisor: Rodolphe Thiébaut.
2007 MD Thesis, Institute of Medical Virology, Justus Liebig University Giessen,
Germany. Supervisor: Wolfram Gerlich.
2007 Master of Epidemiology and Biostatistics, Bordeaux School of Public Health
(ISPED), University of Bordeaux 2, France.
2006 Master 1 in Public Health, Bordeaux School of Public Health (ISPED),
University of Bordeaux 2, France.
1997-2003 Studies of human medicine at the Justus Liebig University, Giessen, Germany
and the University Autonoma, Madrid, Spain.
Professional experiences
Since 2009 Project coordinator of the EuroCOORD-CHAIN joint project on transmitted
drug resistance.
2007 Practical training for the Master of Epidemiology and Biostatistics in the
biostatics team. Supervisor: Rodolphe Thiébaut.
2006 Practical training for the Master 1 in the biostatics team. Supervisor: Rodolphe
Thiébaut.
2004/2005 Senior house officer in Internal Medicine at the Klinikum Wetzlar-Braunfels,
Germany.
2003/2004 Junior house officer in Internal Medicine at the Klinikum Wetzlar-Braunfels,
Germany.
1999-2002 Experimental work for the MD thesis at the Institute of Medical Virology,
Justus Liebig University Giessen, Germany.
Teaching experiences
Since 09/2008 ‘Monitor position’ in Statistics (equivalent to 64h of teaching per year).
2009 Co-Supervisor (with Marthe-Aline Jutand) of Tien Dung Nguyen, a Master 1
student, during a practical training entitled: “Long term follow up of HIV-1
infected patients with sustained viral load suppression who switched to a
fosamprenavir/r based HAART.”
2009 Supervision of 4 Master 1 students (Fabien Le Marec, Simon Lorrain,
Clemence Perel, Solène Tatiboeut) for a project entitled “Genotypic Mutations
of the Hepatitis B Virus Capsid: Prevalences and Impacts.”
2008 Co-supervisor (with Rodolphe Thiébaut) of Marion Izotte, a Master 1 student
during, the practical training in the team of biostatistics: “Comparison of active
nuclear transport of BSA-M9 and BSA-NLS and passive diffusion of BSA
under different experimental conditions in HuH-7 and HeLa cells using
multivariate linear models.”

Since 2007 Teaching at the Bordeaux School of Public Health ISPED (Epidemiology,
Introduction to SAS, Medical basics (co-responsible), Introduction to
statistics…).
2003-2005 Teaching of MD students at the Klinikum Wetzlar-Braunfels, Germany.
Publications
2009 Wittkop L, Breilh D, Da Silva D, Duffau P, Mercié P, Raymond I, Anies G,
Fleury H, Saux MC, Dabis F, Fagard C, Thiébaut R, Masquelier B, Pellegrin I.
Virological and immunological response in HIV-1-infected patients with
multiple treatment failures receiving raltegravir and optimized background
therapy, ANRS CO3 Aquitaine Cohort. J Antimicrob Chemother 2009
Jun;63(6):1251-5.
Wittkop L, Grün-Bernhard S, Schwarz A, Delaleau M, Rabe B, Cazenave C,
Glebe G, Kann K. Proteinkinase C Activity in capsids of Hepadnaviruses
decreases capsid stability and enhances virus secretion; reviewed for Cell
Microbiol.
Wittkop L, Smith C, Fox Z, Sabin C, Richert L, Aboulker JP, Philipps A,
Chêne G, Babiker A, Thiébaut R on behalf of NEAT WP4. Methodological
issues in the use of composite endpoints in clinical trials: examples from the
HIV field. accepted for Clinical Trials.
S Deshpande, AC Jeanno, MH Schrive, L Wittkop, P Pinson, HJ Fleury.
Analysis of RT sequences of subtype C HIV-1 isolates from Indian patients at
failure of a first line treatment according to clinical and/or immunological WHO
guidelines. accepted for AIDS Research and Human Retroviruses.
S. Reigadas, ML. Andreola, L Wittkop, O. Cosnefroy, G. Anies, P Recordon-
Pinson, R Thiébaut, B. Masquelier and H. Fleury. Evolution of 2-LTR
episomal HIV-1 DNA in Raltegravir-treated patients and in in vitro infected
cells. reviewed for JAC
D Da Silva, L Van Wesenbeeck, D Breilh, S Reigadas, G Anies , K Van
Baelen, P Morlat, D Neau, Ml Dupon, L Wittkop, H Fleury and B Masquelier.
HIV-1 resistance patterns to integrase inhibitors in antiretroviral -experienced
patients with virological failure on raltegravir-containing regimens. Submitted
to JAIDS.
2008 Wittkop L. Die Hepatitis B Virus Proteinkinase - Natur und Funktion der
Hepatitis B Virus Proteinkinase. Saarbrücken: VDM Verlag Dr. Müller, 2008.
ISBN 3639067274.
Wittkop L, Pellegrin I, Joubert LM, Neau D, Bollens D, Bonarek M, Girard
PM, Fleury H, Winters B, Saux MC, Pellegrin JL, Thiébaut R, Breilh D; ANRS
Co3 Aquitaine Cohort. Virological response to darunavir/ritonavir-based
regimens in antiretroviral-experienced patients (PREDIZISTA study). Antivir
Ther 2008,13(2):271-9.
Wittkop L, Commenges D, Pellegrin I, Breilh D, Neau D, Lacoste D, Pellegrin
JL, Chêne G, Dabis F, Thiébaut R. Alternative methods to analyse the impact
of HIV mutations on virological response to antiviral therapy. BMC Med Res
Methodol 2008,8:68.