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Pharmacological Management of Acute Kidney Injury

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Prevention <strong>of</strong> radiocontrast-induced nephropathy. Asif A,<br />

Epstein M. Am J <strong>Kidney</strong> Dis. 2004 Jul;44(1):12-24<br />

Radiocontrast is a common cause <strong>of</strong> hospitalacquired<br />

ARF mainly in patients with preexisting<br />

renal failure<br />

Saline hydration is the sole proven effective<br />

protection<br />

The benefits <strong>of</strong> the antioxidant N-acetylcysteine, isoosmolar<br />

contrast agents, fenoldopam (dopamine-1 [DA-<br />

1] receptor agonist), hemodialysis, and hem<strong>of</strong>iltration,<br />

are less certain.

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