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Pharmacological Management of Acute Kidney Injury

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Fenoldopam<br />

Crit Care Med. 2005 Nov;33(11):2451-6.<br />

Prophylactic fenoldopam for renal protection in sepsis: a<br />

randomized, double-blind, placebo-controlled pilot trial.<br />

Fenoldopam, a dopamine-1 receptor agonist, increases renal blood<br />

flow and may, therefore, reduce the risk <strong>of</strong> acute renal failure in<br />

such patients. 300 septic patients fenoldopam vs placebo<br />

No significant difference in incidence <strong>of</strong> severe<br />

ARF but smaller rises in creatinine in the<br />

fenoldopam group

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