Pharmacological Management of Acute Kidney Injury
Pharmacological Management of Acute Kidney Injury
Pharmacological Management of Acute Kidney Injury
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Atrial Natriuretic Peptide for <strong>Management</strong> <strong>of</strong> <strong>Acute</strong> <strong>Kidney</strong> <strong>Injury</strong>:<br />
A Systematic Review and Meta-analysis<br />
Clin J Am Soc Nephrol 4: 261-272, 2009<br />
© 2009 American Society <strong>of</strong> Nephrology<br />
• Results: Nineteen RCTs (11 prevention, 8 treatment) involving 1861<br />
participants were included. Pooled analysis <strong>of</strong> prevention trials<br />
showed a trend toward reduction in renal replacement therapy in<br />
the ANP group (OR = 0.45, 95% CI, 0.21 to 0.99) and good safety<br />
pr<strong>of</strong>ile, but no improvement in mortality. For the treatment <strong>of</strong><br />
established AKI, ANP, particularly in high doses, was associated with<br />
a trend toward increased mortality and more adverse events.<br />
Subgroup analysis <strong>of</strong> AKI after a major surgery (14 RCTs, 817<br />
participants) showed a significant reduction in renal replacement<br />
therapy requirement in the ANP group
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