Plasmapheresis - CRRT Online

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<strong>Plasmapheresis</strong> applications Removal of pathogenetic macromolecules from the bloodstream: Autoantibody Probable autoantibody Antigen-Antibody complexes (circulating immune complexes) Alloantibody Paraproteins (light chains, monoclonal cryoglobulins, etc.) Non-immunoglobulin proteins Endogenous toxins Exogenous poisons dmward@ucsd.edu
<strong>Plasmapheresis</strong> applications Autoantibody: Thrombotic Thrombocytopenic Purpura (TTP), Myasthenia gravis (MG), Neuromyelitis Optica (NMO), Anti-GBM GN (& Goodpasture’s), ANCA-nephritis (& Wegener’s), Antiphospholipid crisis, Immune Thrombocytopenia (ITP), etc. Probable autoantibody: Multiple sclerosis (MS), Guillain-Barré (GBS), Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), etc. Antigen-Antibody complexes: Hepatitis C vasculitis, S.L.E., etc. Alloantibody: Transplant sensitization, Transplant rejection (humoral), Transfusion reactions, etc. Paraproteins: Waldenstrom’s, Hyperviscosity, Light-chain neuropathy, Light-chain glomerulopathy, Myeloma cast nephropathy, etc. Non-Ig proteins: Focal Segmental Glomerulosclerosis (FSGS). Endogenous toxins: Hypercholesterolemia, Liver failure, Systemic Inflammatory Response Syndrome (SIRS), etc. Exogenous poisons: Amanita, drugs, etc. dmward@ucsd.edu
Page 1 and 2: Workshop B02 Tuesday February 14 th
Page 3 and 4: WARNING: Many of the hybrid extraco
Page 5 and 6: Case reports Three patients at UCS
Page 7 and 8: Case reports Since 1992 at UCSD, C
Page 9 and 10: Case reports Plasmapheresis goal:
Page 11: Manual plasmapheresis PLASMA REMOVA
Page 15 and 16: Also see Indications for therapeuti
Page 17 and 18: Apheresis methods Manual Plasmapher
Page 19 and 20: Separation by centrifugation
Page 21 and 22: Separation by centrifugation Whole
Page 23 and 24: Separation by centrifugation Plasma
Page 25 and 26: Conventional Therapeutic Apheresis
Page 27 and 28: Intermittent plasmapheresis Prescri
Page 29 and 30: Number of plasmaphereses needed Rem
Page 31 and 32: Distribution of body water Standard
Page 33 and 34: Kinetics of intermittent clearance
Page 35 and 36: Anticoagulation Citrate: 1. Familia
Page 37 and 38: Intermittent plasmapheresis - choic
Page 39 and 40: Plasma regeneration (on-line purifi
Page 41 and 42: Cascade Plasmafiltration (Double-Fi
Page 43 and 44: Antibody Immunoadsorption with Anti
Page 45 and 46: Braun “HELP”® System (Heparin-
Page 47 and 48: Covalently-bound peptide ligands fo
Page 49 and 50: Current use of on-line plasma purif
Page 51 and 52: dmward@ucsd.edu “Resin” adsorpt
Page 53 and 54: Membrane plasmapheresis: from patie
Page 55 and 56: Intermittent Plasmapheresis + citra
Page 57 and 58: Continuous Plasmapheresis + citrate
Page 59 and 60: Continuous Plasmapheresis + CRRT IN
Page 61 and 62: Continuous Plasmapheresis + CRRT IN
Page 63 and 64:
Double Filtration Plasmapheresis +
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