Plasmapheresis - CRRT Online

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Antigen (Ag) columns for Immunoadsorption (IA) blood return from patient dmward@ucsd.edu Purified plasma Whole plasma Perfusion columns containing immobilized antigen can extract specific autoantibodies for anti-GBM nephritis Terman DS, Durante D, Buffaloe G, McIntosh R. Attenuation of canine nephrotoxic glomerulonephritis with an extracorporeal immunoadsorbent. Scand J Immunol. 6:195-202, 1977 for SLE Terman DS, Buffaloe G, Mattioli C, Cook G, Tillquist R, Sullivan M, Ayus JC. Extracorporeal immunoadsorption: initial experience in human systemic lupus erythematosus. Lancet (2):824-7, 1979 Clinically unsuccessful due to Ag leaching
Covalently-bound peptide ligands for Immunoadsorption (IA) blood return from patient Purified plasma Whole plasma Peptide ligands covalently linked to sepharose mimic the epitope and specifically immuno-adsorb pathogenic autoantibodies. effective in Autoimmune type Idiopathic Dilated Cardiomyopathy which is due to autoantibodies with (1) agonist-like effect on the Beta-1 adrenergic receptor (2) now known to cross-react with and damage cardiac myosin. But Ab’s against different epitopes may cause similar disease Wallukat G, Reinke P, Dorffel WV, et al. Removal of autoantibodies in dilated cardiomyopathy by immunoadsorption. Int J Cardiol. 1996; 54:191-195.
Page 1 and 2: Workshop B02 Tuesday February 14 th
Page 3 and 4: WARNING: Many of the hybrid extraco
Page 5 and 6: Case reports Three patients at UCS
Page 7 and 8: Case reports Since 1992 at UCSD, C
Page 9 and 10: Case reports Plasmapheresis goal:
Page 11 and 12: Manual plasmapheresis PLASMA REMOVA
Page 13 and 14: Plasmapheresis applications Autoant
Page 15 and 16: Also see Indications for therapeuti
Page 17 and 18: Apheresis methods Manual Plasmapher
Page 19 and 20: Separation by centrifugation
Page 21 and 22: Separation by centrifugation Whole
Page 23 and 24: Separation by centrifugation Plasma
Page 25 and 26: Conventional Therapeutic Apheresis
Page 27 and 28: Intermittent plasmapheresis Prescri
Page 29 and 30: Number of plasmaphereses needed Rem
Page 31 and 32: Distribution of body water Standard
Page 33 and 34: Kinetics of intermittent clearance
Page 35 and 36: Anticoagulation Citrate: 1. Familia
Page 37 and 38: Intermittent plasmapheresis - choic
Page 39 and 40: Plasma regeneration (on-line purifi
Page 41 and 42: Cascade Plasmafiltration (Double-Fi
Page 43 and 44: Antibody Immunoadsorption with Anti
Page 45: Braun “HELP”® System (Heparin-
Page 49 and 50: Current use of on-line plasma purif
Page 51 and 52: dmward@ucsd.edu “Resin” adsorpt
Page 53 and 54: Membrane plasmapheresis: from patie
Page 55 and 56: Intermittent Plasmapheresis + citra
Page 57 and 58: Continuous Plasmapheresis + citrate
Page 59 and 60: Continuous Plasmapheresis + CRRT IN
Page 61 and 62: Continuous Plasmapheresis + CRRT IN
Page 63 and 64: Double Filtration Plasmapheresis +

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