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List of Posters POSTER 20 A. Korpala, D. Kruk, S. Mehdizadeh Taheri, S. Fӧrster, E.A. Rӧssler 1 H relaxation in solutions of superparamagnetic nanoparticles POSTER 21 J. Perlo, G. Dominguez, E. Anoardo Measurement of the bending elastic modulus in unilamellar vesicles membranes by fast field cycling NMR relaxometry POSTER 22 D. Pooke, J. de Feijter, M. Mallett, S. Bubici Cryogen-free superconducting magnet design for NMR POSTER 23 S. Bubici, R. Steele, G. Ferrante Fast field cycling relaxometry: moving from research towards industrial applications POSTER 24 S. Bubici, R. Steele, G. Ferrante Method for NMR relaxometry on hetero-nuclei at very low fields POSTER 25 G. Ferrante, R. Cernuschi, R. Rolfi, R. Gatti, J. Barras, G. Kyriakidou, J.A.S. Smith, K. Althoefer Authentication of medicines by Nuclear Quadrupolar Resonance (NQR) analysis; A portable system for non-destructive control of packaged pharmaceutical products POSTER 26 D. Alberti, M. Van't Erve, R. Stefania, M.R. Ruggiero, S. Baroni, S. Geninatti Crich, S. Aime R-ELISA: A quantitative relaxometric version of the ELISA test for the measurement of cell surface biomarkers based on the water proton T 1 measurements <strong>8th</strong> <strong>Conference</strong> on Fast Field Cycling NMR Relaxometry, Turin 23-25 May 2013
Poster 01 Abstract Preparation of highly polarised nuclear spin systems using brute-force <strong>and</strong> low-field thermal mixing Gadian DG 1 , Panesar KS 2 , Perez Linde AJ 2 , Horsewill AJ 2 , Köckenberger W 2 , <strong>and</strong> Owers-Bradley JR 2 1 Institute of Child Health, University College London, WC1N 1EH, UK 2 School of Physics & Astronomy, University of Nottingham, NG7 2RD, UK Several strategies have been developed for generating highly polarised nuclear spin systems, including dynamic nuclear polarisation, optical pumping, <strong>and</strong> methods exploiting parahydrogen. We report here on investigations using an alternative strategy based on a ‘brute-force’ approach. The central notion of ‘brute-force’ NMR is that as the temperature is reduced <strong>and</strong> the field is increased, the equilibrium nuclear polarisation will increase, according to the Boltzmann distribution. The main problem is that it may take an extremely long time for the nuclear polarisation to approach thermal equilibrium at low temperatures <strong>and</strong> high fields, since nuclear relaxation becomes very slow. Cross-polarisation techniques can alleviate this problem. Experiments were carried out using (i) a rapid field-cycling spectrometer that operates at temperatures down to 4.2K <strong>and</strong> delivers magnetic field switches of 10 Ts - 1 , <strong>and</strong> (ii) a millikelvin spectrometer that operates at any chosen field up to 15T, <strong>and</strong> at temperatures as low as 10mK. Field cycling on this system can be carried out at rates of 1T min -1 . Experiments were carried out on [1- 13 C] sodium acetate, either in the form of a powder, or dissolved in a 50/50 water/glycerol solution. In some experiments, sodium phosphate was also added to the water/glycerol solution. We show that low-field thermal mixing can be used to transfer polarisation from the relatively rapidly relaxing 1 H reservoir to more slowly relaxing 13 C <strong>and</strong> 31 P nuclei. The effects are particularly dramatic for the 31 P nuclei, which at 2T <strong>and</strong> 4.2K showed a 75-fold enhancement in their effective rate of approach to equilibrium, <strong>and</strong> an even greater (150-fold) enhancement in the presence of a relaxation agent. The mixing step is also very effective in terms of the amount of polarisation transferred – 70-90% of the maximum theoretical value in the experiments reported here. These findings [1] have important implications for brute-force polarisation. We also show that the 1 H reservoir can be tapped repeatedly through a number of consecutive thermal mixing steps; this could provide additional sensitivity enhancement in solid-state NMR. [1] Gadian DG, Panesar KS, Perez Linde AJ, Horsewill AJ, Köckenberger W, <strong>and</strong> Owers-Bradley JR (2012). Phys. Chem. Chem. Phys. 14: 5397-5402. <strong>8th</strong> <strong>Conference</strong> on Fast Field Cycling NMR Relaxometry, Turin 23-25 May 2013
Page 2 and 3: 8th Confer
Page 4 and 5: Main sponsors The Organizing Commit
Page 6 and 7: Friday 24 May, 2013 Chair: Silvio A
Page 8 and 9: 8 th Conference on
Page 12 and 13: Oral 02 Abstract CHARACTERIZATION O
Page 14 and 15: Oral 04 Abstract Fundamental <stron
Page 16 and 17: Oral 06 Abstract TRANSIENT ACCESS T
Page 18 and 19: Oral 08 Abstract Relaxometry for so
Page 20 and 21: Oral 10 Abstract Spin-Relaxation Ef
Page 22 and 23: Oral 12 Abstract Phase-gradient coi
Page 24 and 25: Oral 14 Abstract Initial Characteri
Page 26 and 27: Oral 16 Abstract The Interplay of M
Page 28 and 29: Oral 18 Abstract Water dynamics at
Page 30 and 31: Oral 20 NMR relaxation of fluids co
Page 32 and 33: Oral 22 Abstract Theory and
Page 34 and 35: Oral 24 Abstract Using Relaxometry
Page 36 and 37: Oral 26 Abstract NMR relaxometry <s
Page 38 and 39: Oral 28 Abstract DYNAMICS OF P3HT I
Page 40 and 41: Oral 30 Abstract Field-cycling doub
Page 44 and 45: List of Posters POSTER 1 D.G. Gadia
Page 48 and 49: Poster 02 Abstract Multi-dynamics s
Page 50 and 51: Poster 04 Abstract Application of F
Page 52 and 53: Poster 06 Abstract Multiscale dynam
Page 54 and 55: Poster 08 Abstract Field-Cycling Ov
Page 56 and 57: Poster 10 Abstract Angular dependen
Page 58 and 59: Poster 12 Abstract A Straightforwar
Page 60 and 61: Poster 14 Abstract Fast-field cycli
Page 62 and 63: Poster 16 Abstract Rapid Field-Cycl
Page 64 and 65: Poster 18 Abstract NMR Relaxation-V
Page 66 and 67: Poster 20 Abstract 1 H relaxation i
Page 68 and 69: Poster 22 Abstract Cryogen-Free Sup
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Page 72 and 73: Poster 26 Abstract R-ELISA: A quant

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