Microbial Diseases of the Nervous System
Microbial Diseases of the Nervous System
Microbial Diseases of the Nervous System
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Rabies Virus (<strong>of</strong> Rhabdoviridae)<br />
• Zoonosis – Transmission from saliva <strong>of</strong> rabid animal<br />
• Virus multiplies in skeletal muscles, <strong>the</strong>n retrograde<br />
axonal transport to CNS (encephalitis), <strong>the</strong>n back out<br />
to periphery (salivary glands etc.)<br />
• Initial symptoms may include muscle spasms <strong>of</strong> <strong>the</strong><br />
mouth and pharynx and hydrophobia.<br />
• Furious rabies: Animals<br />
restless <strong>the</strong>n highly<br />
excitable.<br />
• Paralytic rabies: Animals<br />
unaware <strong>of</strong> surroundings.<br />
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