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FARMACOLOGIA DEL SISTEMA INMUNE

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The importance of CD28-mediated costimulation has also been demonstrated in vivo.<br />

Blockade of CD28-mediated costimulation has been shown to:<br />

• Prolong graft survival<br />

• Block primary antibody response<br />

• Prevent or reduce in intensity experimentally, antigen-induced models of<br />

autoimmunity including arthritis, encephalomyelitis, myocarditis, thyroiditis and<br />

myasthenia gravis

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