FARMACOLOGIA DEL SISTEMA INMUNE

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Wulfing, C. and and Davies, M.M. Science 282:2266, 1998. 1. Actine cytoskeleton reorients toward the T cell-APC interface soon after the start of T cell activation Beads are attached to the surface of T cells and monitor the movement of the cytoskeleton in the T cells. Figure 1. Bead movement toward the interface. Single frames of a video microscopy experiment (36) of the interaction of 5C.C7 T cells, loaded with 4.5-µm anti-ICAM-1 (YN1) beads, with peptide-loaded CH27 B cell lymphoma cells (35) are shown. The CH27 cell is substantially larger than the T cells. The T cell intracellular calcium concentration is overlaid in a false color scale from blue (low concentration) to red (high concentration) to mark the onset of T cell activation, set to time 0:00 min. Although the beads, one of which is marked with an arrow, are bound to the posterior end of the central T cell before and at the time of its activation, they can be seen to move toward the T cell-B cell interface in subsequent frames.
Thus, in addition to a role in initial activation of T cells, B7/CD28 interactions are important in promoting T cell tolerance because they have a critical role in the homeostasis of CD4+ CD25+ regulatory T cells which play an essential role in regulating self-tolerance.
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Page 5 and 6: INMUNOSUPRESIÓN
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Page 13 and 14: The Two-Signal Model of T-cell Acti
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