FARMACOLOGIA DEL SISTEMA INMUNE

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Mechanism The conventional view CD28 delivers intracellular signals that synergize distally with the TCR signaling pathways, at the level of JUN-kinase.
The new concept (based on the visualization of T cell activation) Kupfer et al. have shown that T cells polarize toward the APCs, thereby forming a highly structured synapse (the immune synapse). This process involves a redistribution of surface and intracellular molecules. Some molecules, such as TCR, CD4, src kinases are enriched in a central zone, whereas others, such as LFA-1 and CD45, remain outside. • helps maintaining the interaction between the TCR and the peptide/MHC complexes (low concentration and low affinity for the TCR) • helps in the local accumulation of intracellular signaling complexes
Page 1 and 2: FARMACOLOGIA DEL SISTEMA INMUNE Inm
Page 5 and 6: INMUNOSUPRESIÓN
Page 7 and 8: Jean Francois Borel
Page 9: Estructura de la ciclosporina
Page 13 and 14: The Two-Signal Model of T-cell Acti
Page 15 and 16: Marc Jenkins and Ronald Schwartz in
Page 17 and 18: Cells with this costimulatory funct
Page 19 and 20: In vitro T cell responses in CD28 K
Page 21: Major effects of CD28-mediated cost
Page 25 and 26: Thus, in addition to a role in init
Page 27 and 28: Mab ANTI CTLA-4 (Ipililumab)
Page 29 and 30: mAb against CTLA-4 was found to co
Page 31 and 32: Phenotype of CTLA-4 KO mice This is
Page 33 and 34: CTLA-4 is not readily detectable in
Page 35 and 36: The threshold model:When B7 levels
Page 37 and 38: There are two scenarios in which CT
Page 39 and 40: The attenuation model:When B7 level
Page 41 and 42: CTLA-4 would prevent this high-affi
Page 43 and 44: T cell-mediated immunotherapy repre

FARMACOLOGIA DEL SISTEMA INMUNE

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