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99 Hyperbaric Oxygenation Therapy KCE Reports 74
9 APPENDICES
APPENDIX FOR THE CHAPTER ON CLINICAL
EFFECTIVENESS (CHAPTER 3)
SEARCH STRATEGY
As explained in the chapter on clinical effectiveness, most of the individual RCTs have
been performed in small groups. Therefore, we have focussed our search on metaanalyses
and systematic reviews. Exploratory searches learned that the MeSH term
‘hyperbaric oxygenation’ covered very well the subject but we additionally also used these
words as keyword in our Medline and Embase searches.
All searches were performed in early December 2007 and details about the searches in
Medline/Pubmed and Embase are shown in Table 38. We additionally searched the CRD
databases (DARE, NHS/EED and HTA) with the MeSH term ‘Hyperbaric oxygenation’,
providing 48 hits, and the several Cochrane databases with the same MeSH term leading
to 271 documents. Overall 472 references were obtained through this procedure, in
many cases, however, either duplicates of what was detected in the previous searches
or individual clinical trials. After electronic elimination of duplicates we retained 372
references. The final selection and exclusion process of manuscripts is represented in
the flow chart in Figure 1 in the chapter on clinical effectiveness.
Table 38. Search strategy and results for Medline/Pubmed and Embase
Medline (Pubmed)
#1 Search hyperbaric oxygenation[Mesh] 8459
#2 Search systematic[sb] 99648
#3 Search #1 AND #2 86
#4 Search hyperbaric 11439
#5 Search oxygenation 41576
#6 Search #4 and #5 8597
#7 Search #1 or #6 8597
#8 Search #7 and #2 87
#9
Embase
# 8 and Publication Date from 2000/01/01 82
#1
('hyperbaric oxygenation'/exp OR 'hyperbaric oxygenation')
AND [2000-2007]/py
3013
#2
('systematic review'/exp OR 'systematic review') AND
[2000-2007]/py
27830
#3 #1 AND #2
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