Microflow Radioactivity Detector M ira Star - raytest

Mira Star
Microflow
Radioactivity
Detector
for µ-HPLC
4 detectors in 1
sr 09/04

MICROFLOW-RADIO-HPLC
Mira Star flow detector
and electronics
Micro Ramona Star is a newly
d e v e l o p e d r a d i o a c t i v i t y
flowthrough detector for the
application of microflow or capillary
HPLC.
Mira Star consists of a separate
detector unit and an electronic
module to position the detector as
close as possible to the µ-HPLC
system to reduce peak broadening
by long capillaries between the
individual HPLC components.
Mira Star and a microflow-
HPLC-system
4 DETECTOR S
IN 1
Mira Star has 4 separate
coincidence flow detectors aligned
in series in one detector. Every
single separate subdetector
counts the flowthrough activity
profile in the small cell volume. At
the end, all 4 profiles are
s e q u e n t i a l l y d e l a y e d ,
accumulated in phase and added
to one peak profile. Therefore the
sensitivity is 4 times higher than 1
flowdetector.
Flow rates in microflow HPLC are
typically in the range of 10-100
µl/min. Typically µ-flow HPLC
columns have internal diameters of
less than 1 mm. The separation
performance of these columns is
equal or even higher than standard
HPLC columns. The consumption
of eluents is for µ-HPLC
applications much lower than in
standard HPLC. And therefore the
disposal of contaminated eluent
waste is less laborous and less
expensive.
Small column diameter means
small sample volume injection for
separation.
Small sample volume means that
separated fractions in HPLC have
a very small peak volume.
Small peak volume produce small
activity peaks (small numbers of
counts detected).
To obtain sufficient sensitivity for
these small numbers of counts it
was required to mount four
separate subdetectors in series.
VERSA TILE APPLICATIONS Mira Star internal
solid scintillator cell
Mira Star can be equipped with
various flowcells with solid
scintillators for almost every
application. Scintillator materials
are CaF and Li-glass as well as a
new scintillator material, called US.
The different solid scintillator cells
are available in various volumes
and many grades of particle size
to optimize sensitivity and
resolution.

FLEXI BLE USE
Mira Star external
solid scintillator cell
Mira Star also can be equipped
with flowcells with external solid
scintillators. A coil of PTFE-tubing
is positioned between 2 solid
scintillator disks. The radiation
penetrates the wall of the tubing
and hits the external scintillator
disk. Such an arrangement is
suitable for high energy beta
applications with plastic scintillator
material or low energy gamma
applications with BGO-scintillator
disks. The cell volume can be
customized to the required size.
LIQUID SCINTILLATOR ADMIXTURE
Mira Star liquid scintillator cell
Mira Star is suitable for liquid
scintillator admixture using liquid
scintillator cells and the Ramona
HPLC-LS pump with a delivery
rate of 100-2000 µl/min. Capillary
tubing and small flowcell volume
require low viscosity liquid
s c i n t i l l a t o r c o c k t a i l s . B i o -
degradable LS-cocktails are
preferred.
Mira Star LS-admixture pump
GLP A ND GMP COMPLIANCE Mira Star flow cell identification
Mira Star flow cells have the same
unique cell recognition feature as
Ramona Star. Every flowcell
carries a readable microchip,
storing the individual identification
and all parameters required for
GLP and GMP compliance. Data
f r o m t h i s m i c r o c h i p a r e
automatically transferred to Gina
Star software.
Mira Star can easily be integrated
into a microflow HPLC-system,
e v e n w h e n u s i n g a
massspectrometric detector
(MSD).
Agilent MSD

aytest Worldwide
raytest Isotopenmessgeräte GmbH
Benzstr. 4
D-75334 Straubenhardt
Tel +49 7082 92550
info@raytest.de
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Uferstr. 15-19/9
A-2103 Langenzersdorf
Tel +43 2244 30 890
austria@raytest.de
raytest BeNeLux B.V.
Spoorlaan 438A
NL-5038 CH Tilburg
Tel +31 135 4336 19
benelux@raytest.de
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Cedex
F-92052 Paris la Defense
Tel +33 1 433 433 33
france@raytest.de
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Via G. Matteotti, 54/66
I-20092 Cinisello Balsamo
Tel +39 02 6129 3798
italy@raytest.de
raytest Iberica S.L.
Travador, 43-35 bajos
E-08041 Barcelona
Tel +34 93 4500 875
iberica@raytest.de
raytest Schweiz AG
Bernstr. 388
CH-8953 Dietikon
Tel +41 1740 1069
switzerland@raytest.de
raytest USA Inc.
515 Cornelius Harnett Drive
Wilmington NC 2840
Tel +1 910 343 1830
Usa@raytest.de
Raytek Scientific Ltd
26 Norton Park View
Sheffield S8 8GS
Tel +44 0114 274 9575
uk@raytest.de
Technical data
eluate flow rate: 10 - 300 µl/min
dead volume: 1 - 2 µl
connection: capillary tubing
14C, 33P, 35S etc
Internal solid scintillator: US, CaF, Li-glass
particle size 30 > 100 µm
cell volume 4 x (3 - 45) µl
efficiency 40 - 90%
3H
internal liquid scintillator: 200 - 2000 µl/min
cell volume 4 x (3 - 100) µl
efficiency 40 - 60%
32P etc
external solid scintillator: plastic or
Cerenkov
effect
cell volume 4 x (3 - 100) µl
efficiency 60 - 80%
125I etc
external solid scintillator BGO
cell volume 4 x (3 - 100) µl
efficiency 20 - 30%
standalone detector
detector module: 250 x 80 x 200 mm
(B x H x T)
low dead volume
connection
electronic module: 320 x 170 x 260 mm
(B x H x T)
data transfer: analog, 0-1V (21 bit)
Gina Star detector control
same as stand alone but including data
transfer to Gina Star software
Digital (single event counting), never out-of-
range problems, never smoothing problems,
digital peak integration, calculation of
statitistical variation, calculation of limit of
detection, simple validation
raytest Isotopenmessgeräte GmbH
Benzstrasse 4, 75334 Straubenhardt
www.raytest.de • info@raytest.de
Tel. +49 (7082) 9255-0
Fax. +49 (7082) 20813
Mira Star detector, electronics, flow cell
Mira Star front panel
Mira Star back panel
raytest USA, Wilmington, NC • raytek Scientific UK, Sheffield • raytest Italia, Cinisello Balsamo • raytest France, Courbevoie • raytest Benelux, Tilburg
raytest Switzerland, Dietikon • raytest Iberica, Barcelona • raytest Austria, Langenzersdorf