Human Health Risk Assessment - Raytheon

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DRAFT Table 7. Physical and Chemical Properties of COPCs Human Health Risk Assessment MW H H' Di Dw Koc Kd log Kow Kp * S DA VF SAT kg kl Kol (g/mol) (atm-m 3 /mol) (dimensionless) (cm 2 /s) (cm 2 /s) (cm 3 /g) (cm 3 /g) (cm/hr) (mg/L-water) (cm 2 /s) (m 3 /kg) (mg/kg) (cm/hr) (cm/hr) (cm/hr) Acetone 58.0 3.9E-05 1.6E-03 1.2E-01 1.1E-05 5.8E-01 3.5E-03 -0.24 5.2E-04 1.0E+06 9.9E-05 1.2E+04 1.0E+05 1.7E+03 1.7E+01 2.3E+00 Benzene 78.1 5.6E-03 2.3E-01 8.8E-02 9.8E-06 5.9E+01 3.5E-01 2.13 1.5E-02 1.8E+03 2.1E-03 2.6E+03 8.7E+02 1.4E+03 1.5E+01 1.4E+01 carbon disulfide 76.0 3.0E-02 1.2E+00 1.0E-01 1.0E-05 4.6E+01 2.7E-01 2.24 1.8E-02 1.2E+03 1.1E-02 1.1E+03 7.2E+02 1.5E+03 1.5E+01 1.5E+01 chloroethane 65.0 1.1E-02 4.5E-01 1.0E-01 1.2E-05 1.5E+01 8.8E-02 1.43 6.0E-03 5.7E+03 8.9E-03 1.3E+03 1.6E+03 1.6E+03 1.6E+01 1.6E+01 chloroform 119.0 3.7E-03 1.5E-01 1.0E-01 1.0E-05 4.0E+01 2.4E-01 1.97 6.8E-03 7.9E+03 2.2E-03 2.6E+03 2.9E+03 1.2E+03 1.2E+01 1.1E+01 1,1-dichloroethane 99.0 5.6E-03 2.3E-01 7.4E-02 1.1E-05 3.2E+01 1.9E-01 1.79 6.7E-03 5.1E+03 2.7E-03 2.3E+03 1.7E+03 1.3E+03 1.3E+01 1.3E+01 1,2-dichloroethane 99.0 9.8E-04 4.0E-02 1.0E-01 9.9E-06 1.7E+01 1.0E-01 1.48 4.2E-03 8.5E+03 1.0E-03 3.8E+03 1.8E+03 1.3E+03 1.3E+01 1.1E+01 1,1-dichloroethene 97.0 2.6E-02 1.1E+00 9.0E-02 1.0E-05 5.9E+01 3.5E-01 2.13 1.2E-02 2.3E+03 7.6E-03 1.4E+03 1.5E+03 1.3E+03 1.3E+01 1.3E+01 cis-1,2-dichloroethene 97.0 4.1E-03 1.7E-01 7.4E-02 1.1E-05 3.6E+01 2.1E-01 1.86 7.7E-03 3.5E+03 1.8E-03 2.8E+03 1.2E+03 1.3E+03 1.3E+01 1.3E+01 trans-1,2-dichloroethene 97.0 9.4E-03 3.8E-01 7.1E-02 1.2E-05 5.3E+01 3.2E-01 1.86 7.7E-03 6.3E+03 2.9E-03 2.2E+03 3.1E+03 1.3E+03 1.3E+01 1.3E+01 1,2-dichloropropane 113.0 2.8E-03 1.1E-01 7.8E-02 8.7E-06 4.4E+01 2.6E-01 2.00 7.7E-03 2.8E+03 1.2E-03 3.4E+03 1.1E+03 1.2E+03 1.2E+01 1.1E+01 1,4-dioxane 88.1 3.00E-06 1.2E-04 8.7E-02 9.3E-06 3.5E+00 -0.27 3.4E-04 miscible 6.1E-06 4.8E+04 1.4E+03 1.4E+01 1.6E-01 ethylbenzene 106.2 7.9E-03 3.2E-01 7.5E-02 7.8E-06 3.6E+02 2.2E+00 3.15 4.8E-02 1.7E+02 5.3E-04 5.2E+03 4.0E+02 1.2E+03 1.3E+01 1.2E+01 isopropylbenzene 120.0 1.2E-02 4.7E-01 7.5E-02 7.1E-06 2.2E+02 1.3E+00 1.95 6.5E-03 6.1E+01 1.2E-03 3.4E+03 3.2E+01 1.2E+03 1.2E+01 1.2E+01 methyl ethyl ketone 72.0 2.7E-05 1.1E-03 9.0E-02 9.8E-06 4.5E+00 2.7E-02 0.29 9.7E-04 2.7E+05 4.1E-05 1.9E+04 3.4E+04 1.5E+03 1.6E+01 1.5E+00 methyl isobutyl ketone 100.0 1.4E-04 5.7E-03 7.5E-02 7.8E-06 1.3E+02 8.0E-01 1.31 3.2E-03 1.9E+04 2.5E-05 2.4E+04 1.7E+04 1.3E+03 1.3E+01 4.7E+00 methylene chloride 85.0 2.2E-03 9.0E-02 1.0E-01 1.2E-05 1.2E+01 7.0E-02 1.25 3.5E-03 1.3E+04 2.5E-03 2.4E+03 2.5E+03 1.4E+03 1.4E+01 1.3E+01 4-methylphenol 108.1 1.0E-06 4.1E-05 7.4E-02 8.3E-06 9.1E+01 1.95 7.6E-03 2.1E-06 1.2E+03 1.3E+01 5.0E-02 phenol 94.1 4.0E-07 1.6E-05 8.2E-02 9.1E-06 2.9E+01 1.46 4.3E-03 8.3E+04 1.3E-06 1.1E+05 1.3E+03 1.4E+01 2.1E-02 tetrachloroethene 165.8 1.8E-02 7.5E-01 7.2E-02 8.2E-06 1.6E+02 9.3E-01 3.40 3.3E-02 2.0E+02 2.4E-03 2.4E+03 2.3E+02 9.9E+02 1.0E+01 1.0E+01 toluene 92.0 6.6E-03 2.7E-01 8.7E-02 8.6E-06 1.8E+02 1.1E+00 2.73 3.1E-02 5.3E+02 9.8E-04 3.8E+03 6.5E+02 1.3E+03 1.4E+01 1.3E+01 1,1,1-trichloroethane 133.0 1.7E-02 7.1E-01 7.8E-02 8.8E-06 1.1E+02 6.6E-01 2.49 1.3E-02 1.3E+03 3.2E-03 2.1E+03 1.2E+03 1.1E+03 1.2E+01 1.1E+01 1,1,2-trichloroethane 133.0 9.1E-04 3.7E-02 7.8E-02 8.8E-06 5.0E+01 3.0E-01 2.05 6.4E-03 4.4E+03 3.7E-04 6.2E+03 1.8E+03 1.1E+03 1.2E+01 9.0E+00 trichloroethene 131.0 1.0E-02 4.2E-01 7.9E-02 9.1E-06 1.7E+02 1.0E+00 2.42 1.2E-02 1.1E+03 1.5E-03 3.1E+03 1.3E+03 1.1E+03 1.2E+01 1.1E+01 1,2,4-trimethylbenzene 120.0 5.7E-03 2.3E-01 7.5E-02 7.1E-06 3.7E+03 2.2E+01 3.78 1.1E-01 5.7E+01 4.0E-05 1.9E+04 1.3E+03 1.2E+03 1.2E+01 1.2E+01 1,3,5-trimethylbenzene 120.0 7.7E-03 3.2E-01 7.5E-02 7.1E-06 8.2E+02 4.9E+00 3.42 6.1E-02 4.8E+01 2.4E-04 7.7E+03 2.4E+02 1.2E+03 1.2E+01 1.2E+01 xylenes 106.0 7.3E-03 3.0E-01 7.0E-02 7.8E-06 4.1E+02 2.4E+00 3.20 5.2E-02 1.6E+02 4.2E-04 5.9E+03 4.2E+02 1.2E+03 1.3E+01 1.2E+01 vinyl chloride 63.0 2.7E-02 1.1E+00 1.1E-01 1.2E-05 1.9E+01 1.1E-01 1.36 5.6E-03 2.8E+03 1.5E-02 9.9E+02 1.2E+03 1.6E+03 1.7E+01 1.7E+01 data obtained from Region IX PRG table unless otherwise noted MW molecular weight DA effective diffusion coefficient log Kow for acetone and MIBK obtained from http://www.arb.ca.gov/db/solvents/all_cmpds.htm H Henry's Law Constant VF soil volatilization factor * estimated from USEPA Equation 3.8 in Dermal Guidance (2004) H' dimensionless Henry's Law Constant SAT Saturated soil concentration log Kow obtained from USEPA Dermal Guidance (2004) Di diffusivity in air kg gas phase mass transfer coefficient MW, H and Koc for 1,4-dioxane obtained from Environmental Claims Journal 16:69-79 (2004) Dw diffusivity in water kl liquid phase mass transfer coefficient Note: H' = 41 * H Koc organic carbon/water partition coefficient Kol overall mass transfer coefficient Kow for 1,2,4-trimethylbenzene obtained from SRC ChemFate database (http://www.syrres.com/esc/chemfate.htm) Kd soil/water partition coefficient Kow for 1,3,5-trimethylbenzene obtained from HSDB (http://toxnet.nlm.nih.gov) Kow octanol/water partition coefficient Data for phenol obtained from USEPA's Soil Screening Guidance Technical Background Document Kp skin permeabiity coefficient Data for 2-methylphenol from Soil Screening Guidance used as a surrogate for 4-methylphenol S solubility in water ENVIRON Page 1 of 1
DRAFT Table 8. Source and Derivation of Toxicity Values COPCs in Indoor Air Skin Absorption Source GI Absorption Source Cancer Class Source IUR 1/(ug/m3) Source CSFo 1/(mg/kg-day) Source CSFi 1/(mg/kg-day) Source CSFd 1/(mg/kg-day) Carcinogens benzene 0.9 A A I 7.80E-06 I 5.50E-02 I 2.73E-02 E 6.11E-02 E chloroethane 1 R NA NA 2.90E-03 N 2.90E-03 E 2.90E-03 E chloroform 1 A B2 I 2.30E-05 I NA 8.05E-02 E NA 1,2-dichloroethane 1 A B2 H 2.60E-05 I 9.10E-02 I 9.10E-02 E 9.10E-02 E 1,2-dichloropropane 1 A B2 H NA 6.80E-02 H 6.80E-02 E 6.80E-02 E 1,4-dioxane 0.1 9 1 R B2 I NA 1.10E-02 I 1.10E-02 E 1.10E-02 E methylene chloride 1 A B2 I 4.70E-07 I 7.50E-03 I 1.65E-03 E 7.50E-03 E tetrachloroethene 1 A NA NA 5.20E-02 N 2.00E-03 N 5.20E-02 E 1,1,2-trichloroethane 0.81 A C I 1.60E-05 I 5.70E-02 I 5.60E-02 E 7.04E-02 E trichloroethene 0.945 A B2 H NA 1.10E-02 N 6.00E-03 N 1.16E-02 E vinyl chloride 0.875 A A I 4.40E-06 I 7.20E-01 I 1.54E-02 E 8.23E-01 E Skin Absorption Source GI Absorption Source Critical Effect Source RfC (mg/m3) Source RfDo (mg/kg-day) Source RfDi (mg/kg-day) Source RfDd (mg/kg-day) NonCarcinogens acetone 1 R Kidney, Liver, Neuro NA 9.00E-01 I 9.00E-01 E 9.00E-01 E benzene 0.9 A Blood 3.00E-02 I 4.00E-03 I 8.57E-03 E 3.60E-03 E carbon disulfide 1 R Development, Neuro 7.00E-01 I 1.00E-01 I 2.00E-01 E 1.00E-01 E chloroethane 1 R Developmental 1.00E+01 I 4.00E-01 N 2.86E+00 E 4.00E-01 E chloroform 1 A Liver NA 1.00E-02 I 1.40E-02 N 1.00E-02 E 1,1-dichloroethane 1 R Kidney 5.00E-01 H 1.00E-01 H 1.43E-01 E 1.00E-01 E 1,2-dichloroethane 1 A None Specified NA 3.00E-02 N 3.00E-02 E 3.00E-02 E 1,1-dichloroethene 1 A Liver 2.00E-01 I 5.00E-02 I 5.71E-02 E 5.00E-02 E cis-1,2-dichloroethene 1 R Blood NA 1.00E-02 H 1.00E-02 E 1.00E-02 E trans-1,2-dichloroethene 1 R Blood, Liver NA 2.00E-02 I 2.00E-02 E 2.00E-02 E 1,2-dichloropropane 1 A Nasal 4.00E-03 I 1.10E-03 9 1.14E-03 E 1.10E-03 E 1,4-dioxane 0.1 9 1 R NA NA NA NA ethylbenzene 1 R Develop, Kidney, Liver 1.00E+00 I 1.00E-01 I 2.86E-01 E 1.00E-01 E isopropylbenzene 1 R Adrenals, Kidney 4.00E-01 I 1.00E-01 I 1.14E-01 E 1.00E-01 E methyl ethyl ketone 1 R Developmental 5.00E+00 I 6.00E-01 I 1.43E+00 E 6.00E-01 E methyl isobutyl ketone 1 R Kidney, Liver 3.00E+00 I 8.00E-02 H 8.57E-01 E 8.00E-02 E methylene chloride 1 A Liver 3.00E+00 H 6.00E-02 I 8.57E-01 E 6.00E-02 E 4-methylphenol 0.745 A Neuro, Respiratory NA 5.00E-03 H 3.73E-03 E 3.73E-03 E phenol 1 A Developmental NA 3.00E-01 I 3.00E-01 E 3.00E-01 E tetrachloroethene 1 A Liver NA 1.00E-02 I 1.40E-01 N 1.00E-02 E toluene 1 R Kidney, Liver, Neuro 5.00E+00 I 8.00E-02 I 1.43E+00 E 8.00E-02 E 1,1,1-trichloroethane 1 HS NA 2.80E-01 N 2.86E-01 N 2.80E-01 E 1,1,2-trichloroethane 0.81 A Liver NA 4.00E-03 I 3.24E-03 E 3.24E-03 E trichloroethene 0.945 A NA 6.00E-03 N 5.67E-03 E 5.67E-03 E 1,2,4-trimethylbenzene 1 R NA 5.00E-02 N 1.70E-03 N 5.00E-02 E 1,3,5-trimethylbenzene 1 R NA 5.00E-02 N 1.70E-03 N 5.00E-02 E xylenes 0.895 A Neurological 1.00E-01 I 2.00E-01 I 2.86E-02 E 1.79E-01 E vinyl chloride 0.875 A Liver 1.00E-01 I 3.00E-03 I 2.86E-02 E 2.63E-03 E I = IRIS E = Extrapolated A = ATSDR N = NCEA R = RAGS-E H = HAL (USEPA's 2002 Edition of the Drinking Water Standards and Health Advisories) HE = HEAST HS = HSDB T = TPHCWG 9 = Region 9 PRG Table ENVIRON Page 1 of 1 Human Health Risk Assessment Source Source
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DRAFT Human Health Risk Assessment
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ii Human Health Risk Assessment DRA
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Executive Summary 1 Human Health Ri
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3 Human Health Risk Assessment DRAF
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2 Conceptual Site Model 7 Human Hea
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11 Human Health Risk Assessment DRA
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3.2.3 Ambient Air Sampling 15 Human
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• Inhalation of Outdoor Air On-Si
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Page 27 and 28: u = Wind speed (m/s) 23 Human Healt
Page 33 and 34: EPCa = Exposure point concentration
Page 35 and 36: where: DAD = Dermal absorbed dose (
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Page 41 and 42: non-carcinogenic effects (µg/L) Ri
Page 45 and 46: 5 Toxicity Assessment 41 Human Heal
Page 53 and 54: Potential Risks to On-Site Construc
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Page 59 and 60: 7 Uncertainty Analysis 55 Human Hea
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Page 69 and 70: DRAFT Table 1. Constituents of Pote
Page 71 and 72: DRAFT Table 3. Comparison Between I
Page 73 and 74: DRAFT Table 5. Estimated Exposure P
Page 75: DRAFT Table 6. Summary of Exposure
Page 79 and 80: Human Health Risk Assessment DRAFT
Page 81 and 82: DRAFT Primary Primary Secondary Sec
Page 83 and 84: DRAFT Table A-1. Dose and Risk Calc
Page 89 and 90: DRAFT CSFd RfDd DA event C w DAD LA
Page 93 and 94: DRAFT CSFd RfDd DA event C w DAD LA
Page 95: DRAFT Table A-13. Dose and Risk Cal
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Human Health Risk Assessment - Raytheon

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