Fc-Fusion Proteins: A Growing Class of Therapeutics - Austropa ...
Fc-Fusion Proteins: A Growing Class of Therapeutics - Austropa ...
Fc-Fusion Proteins: A Growing Class of Therapeutics - Austropa ...
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Other Strategies for Protein A Elution• Different acidic buffers:Acetate, Glycine,Citrate, Succinate• Anti-aggregatingExcipients– Polysorbate-80 (Tween-80) at 0.02-0.20%)– Arginine (0.1-1.0M)• Use Alkaline pHpH 11 Elution Conditions Found Effective forAP-<strong>Fc</strong>-D10 <strong>Fusion</strong> ProteinRef: DW Rea, ME Ultee, SX Chen, TL Loisel,Biopharm Intl, Mar 2008 Supp, p20-25ConfidentialSlide 9
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