Fc-Fusion Proteins: A Growing Class of Therapeutics - Austropa ...
Fc-Fusion Proteins: A Growing Class of Therapeutics - Austropa ...
Fc-Fusion Proteins: A Growing Class of Therapeutics - Austropa ...
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Typical IgG Separation Techniques MaybePrevented by the <strong>Fc</strong> <strong>Fusion</strong> Partner• Ex: Anion-Exchange– Used in F/T Mode for IgG’s to remove HCP & DNA– AP-<strong>Fc</strong>-D 10 <strong>Fusion</strong> protein bound irreversibly to AEXdue to D 10 region• Ex: Hydroxylapatite (CHT)– Used to remove aggregates and HCP– AP-<strong>Fc</strong>-D 10 <strong>Fusion</strong> protein bound to CHT but recoverywas only 40%ConfidentialSlide 12
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