Principles of Chemotherapy - Experimental Oncology Graduate Study
Principles of Chemotherapy - Experimental Oncology Graduate Study
Principles of Chemotherapy - Experimental Oncology Graduate Study
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Antimetabolites, contd.Methotrexate• Competitively inhibits dihydr<strong>of</strong>olate reductase (DHFR), theenzyme that converts folic acid to reduced folate c<strong>of</strong>actors (i.e.,tetrahydr<strong>of</strong>olate).• Use includes osteosarcoma, non-Hodgkin's lymphoma,Hodgkin's disease, cutaneous T cell lymphoma, head and neckcancer, lung and breast cancers.• Given orally or intrathecally.• Toxicity: immunosuppressive.18