Principles of Chemotherapy - Experimental Oncology Graduate Study

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Bone marrow transplantation• Allogeneic BMT has been used successfully in the treatment <strong>of</strong>acute leukemia.• Autologous BMT is being used in clinical trials for lymphomapatients.• Developments in autologous BMT include novel methods for exvivo chemopurging (e.g., 4-hydroperoxy-Ctx) or immunopurging(e.g., Shigella like toxin).40
Bone marrow transplantation and gene therapy?• Strategies aim tomanipulate bone marrowstem cells ex vivo.• Examples are themultidrug resistance(MDR) gene and theDNA repair gene O6-alkylguanine DNA alkyltransferase (AGT).CD34 + -PurifiedBone Marrow CellsA gene therapy protocol in which the MDR gene is transferred invitro into cytokine-treated CD34+ bone marrow precursors. Cellsfrom this patient were infected with a recombinant RV carrying theMDR gene and reinfused into the patient before high-dose CT wasadministered41
Page 1 and 2: ONCOLOGY 520CHEMOTHERAPYLecturer: D
Page 3 and 4: Combination CT• Improvements in C
Page 5 and 6: Therapeutic Index, contd.• Such d
Page 7 and 8: Relationship between remission and
Page 9 and 10: Classes of anticancer drugs• “C
Page 11 and 12: a. Nitrogen mustards• Bifunctiona
Page 13 and 14: Melphalan (LMelphalan(L-phenylalani
Page 15 and 16: . Chloroethyl nitrosoureas• The 2
Page 17 and 18: 2. AntimetabolitesDrugs that resemb
Page 19 and 20: Antimetabolites, contd.Cytosine ara
Page 21 and 22: Natural products, contd.Actinomycin
Page 23 and 24: Natural products, contd.VP-16 and V
Page 25 and 26: 4. “Platinating” agents: Cispla
Page 27 and 28: 1. Transport• Mutation/altered ex
Page 29 and 30: Nucleoside analog responsiveness an
Page 31 and 32: 2. Glutathione and associated enzym
Page 33 and 34: 4. Tolerance to DNA damage• In ma
Page 35 and 36: 5. Drug-specific mechanisms• Ctx:
Page 37 and 38: Cell-cycle phase specificity of CT
Page 39: [2] Use of high-dose CT through ove
Page 43 and 44: Gleevec (imatinib mesylate), former
Page 45 and 46: Hypoxic-cell cell cytotoxins: Tirap

Principles of Chemotherapy - Experimental Oncology Graduate Study

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