Principles of Chemotherapy - Experimental Oncology Graduate Study

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Natural products, contd.Vinca Alkaloids• Vinblastine and Vincristine are multi-ring compounds derived from theperiwinkle plant.• They bind to tubulin, thus inhibiting its polymerization to form microtubules anddisrupting the mitotic spindle.Vinblastine is an important drug in combination CT of testicular cancer.• Vincristine is a mainstay of treatment for childhood leukemia.Vincristine22
Natural products, contd.VP-16 and VM-26• VP-16 (etoposide) and VM-26(teniposide) are semisyntheticglycoside derivatives ofpodophyllotoxin that targettopoisomerase II. Etoposide• VP-16 is used to treat small-celllung cancer, testicular cancer,and lymphomas.Mitomycin C• Acts similarly to alkylatingagents.• More active against hypoxicthan against aerobic cells intissue culture. 23Mitomycin C
Page 1 and 2: ONCOLOGY 520CHEMOTHERAPYLecturer: D
Page 3 and 4: Combination CT• Improvements in C
Page 5 and 6: Therapeutic Index, contd.• Such d
Page 7 and 8: Relationship between remission and
Page 9 and 10: Classes of anticancer drugs• “C
Page 11 and 12: a. Nitrogen mustards• Bifunctiona
Page 13 and 14: Melphalan (LMelphalan(L-phenylalani
Page 15 and 16: . Chloroethyl nitrosoureas• The 2
Page 17 and 18: 2. AntimetabolitesDrugs that resemb
Page 19 and 20: Antimetabolites, contd.Cytosine ara
Page 21: Natural products, contd.Actinomycin
Page 25 and 26: 4. “Platinating” agents: Cispla
Page 27 and 28: 1. Transport• Mutation/altered ex
Page 29 and 30: Nucleoside analog responsiveness an
Page 31 and 32: 2. Glutathione and associated enzym
Page 33 and 34: 4. Tolerance to DNA damage• In ma
Page 35 and 36: 5. Drug-specific mechanisms• Ctx:
Page 37 and 38: Cell-cycle phase specificity of CT
Page 39 and 40: [2] Use of high-dose CT through ove
Page 41 and 42: Bone marrow transplantation and gen
Page 43 and 44: Gleevec (imatinib mesylate), former
Page 45 and 46: Hypoxic-cell cell cytotoxins: Tirap

Principles of Chemotherapy - Experimental Oncology Graduate Study

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