TOXICOLOGICAL PROFILE FOR CHROMIUM - Davidborowski.com

36 Rat 2 yr Resp 1.6 (granulomata, giant cells, Steffee and(Wistar) 4 d/wk bronchopneumonia, Baetjer 19654-5 hr/d abscesses) Finely groundchromium roast(VI)37 Mouse(C57BL/6)18 mo Resp5 d/wk5.5 hr/d38 Gn pig 4.5 yr Resp(NS) 4 d/wk4-5 hr/dReproductive39 Rat 3 gen(Wistar) 130 d/gen40 Rat 18 mo(Wistar) 7 d/wk22 hr/dCancer41 Human 90d->5yr42 Human 1 mo -29yr(occup) bTABLE 2-1. Levels of Significant Exposure to Chromium - Inhalation (continued)LOAELExposure/Key to a Species duration/NOAEL Less serious Serious Reference/figure (strain) frequency System (mg Cr/m3) (mg Cr/m3)(mg Cr/m3)Form0.2 M0.1 M4.3 (epithelial necrosis, Nettesheim andhyperplasia) Szakal 1972CaCrO (VI) 41.6 (alveolar and interstitial Steffee andinflammation; alveolar Baetjer 1965hyperplasia, interstitial Mixed chromiumfibrosis) roast K 2Cr 2O 7Na 2CrO 4(VI)Glaser et al 1984Sodiumdichromate (VI)Glaser et al. 1986,1988Chromium (VI)trioxide,Chromium (111)oxide0.413 (CEL: lung cancer) Hayes et al. 1979;Braver et al. 19850.5 M (CEL: lung cancer)mixedHayes et al. 1989PbCrO 4ZnCrO (VI) 4and2. HEALTH EFFECTSCHROMIUM 25