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Hounsfield UnitsHounsfiled UnitsBrain Injured PatientsIntermittentContinuous6050*6050404030302020101000 4 24Time (hrs)00 4 24Time (hrs)GreyWhiteGreyWhiteRonco et al J Nephrol 1999
Does Modality Impact Survival?StudyOdds ratio(95% CI)No. of events<strong>CRRT</strong> IRRTsimpson (1993) 0.50 ( 0.21, 1.20) 46/65 48/58kierdorf (1994) 0.81 ( 0.36, 1.82) 29/48 34/52john (2001) 1.00 ( 0.19, 5.24) 14/20 7/10mehta (2001) 1.89 ( 1.01, 3.52) 54/84 40/82gasparovic (2003) 1.67 ( 0.74, 3.78) 37/52 31/52augustine (2004) 0.89 ( 0.35, 2.29) 27/40 28/40uehlinger (2005) 0.91 ( 0.45, 1.85) 34/70 28/55vinsonneau (2006) 0.95 ( 0.61, 1.48) 118/175 126/184lins (unpublished) 0.83 ( 0.53, 1.31) 100/172 90/144Overall 0.99 ( 0.78, 1.26) 459/726 432/677.1 .25 .5 1 2 4 8Odds ratioFavours <strong>CRRT</strong> Favours IRRTBagshaw et al CCM 2007; Rabindranath et al Cochrane 2007; Pannu et al JAMA 2008
Page 1 and 2: Comparing RRTModalities: Does ItMat
Page 3 and 4: Does It Matter if the Job is Done?
Page 5 and 6: Continuous OR Intermittent?WRONG QU
Page 7 and 8: Azotemic/Uremic Control120100CVVHIH
Page 9 and 10: Volume Homestasis/RemovalVariable I
Page 11 and 12: Systemic Hemodynamics• Therapeuti
Page 13 and 14: IHD sessions complicated by hypoten
Page 15 and 16: Selby et al AJKD 2006
Page 17 and 18: Anticoagulation/Bleeding RiskOR 1.0
Page 19: Fulminant Hepatic Failure SubgroupD
Page 23 and 24: RCT Design: Limitations• No stand
Page 25 and 26: RCT Data: Generalizability•Trials
Page 27 and 28: Recovery to RRT independenceDoes Mo
Page 29 and 30: Does Modality Impact Recovery?Schne
Page 31 and 32: ATN vs RENAL: RecoveryVariable ATN
Page 33 and 34: ATN and RENAL?• Possible explanat
Page 35 and 36: SLED/EDD• Observational single ce
Page 37 and 38: SLED/EDDParameter CVVH EDD PUrea Re
Page 39 and 40: SLED/EDD• Observational single ce
Page 41 and 42: CRRT(n=86)SLED(n=39)pSOFA score 15.
Page 43 and 44: Health Technology Evaluation• HTA
Page 45 and 46: CRRT SLED IHD

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