SLED - CRRT Online

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Does Modality Impact Survival?• SHARF 4 Trial:– 9 centres in Belgium– 316 critically ill patients with AKI (SCr ≥177 µmol/L)Lins et al NDT 2008
RCT Design: Limitations• No standardization of RRT practice• Under-powered (sample size estimates)• Selection bias:– Exclusion of patients with hemodynamic instability– Lack of <strong>CRRT</strong> machine availability– Lack of trained personnel and/or institutionalexpertise
Page 1 and 2: Comparing RRTModalities: Does ItMat
Page 3 and 4: Does It Matter if the Job is Done?
Page 5 and 6: Continuous OR Intermittent?WRONG QU
Page 7 and 8: Azotemic/Uremic Control120100CVVHIH
Page 9 and 10: Volume Homestasis/RemovalVariable I
Page 11 and 12: Systemic Hemodynamics• Therapeuti
Page 13 and 14: IHD sessions complicated by hypoten
Page 15 and 16: Selby et al AJKD 2006
Page 17 and 18: Anticoagulation/Bleeding RiskOR 1.0
Page 19 and 20: Fulminant Hepatic Failure SubgroupD
Page 21: Does Modality Impact Survival?Study
Page 25 and 26: RCT Data: Generalizability•Trials
Page 27 and 28: Recovery to RRT independenceDoes Mo
Page 29 and 30: Does Modality Impact Recovery?Schne
Page 31 and 32: ATN vs RENAL: RecoveryVariable ATN
Page 33 and 34: ATN and RENAL?• Possible explanat
Page 35 and 36: SLED/EDD• Observational single ce
Page 37 and 38: SLED/EDDParameter CVVH EDD PUrea Re
Page 39 and 40: SLED/EDD• Observational single ce
Page 41 and 42: CRRT(n=86)SLED(n=39)pSOFA score 15.
Page 43 and 44: Health Technology Evaluation• HTA
Page 45 and 46: CRRT SLED IHD

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