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Thamma Narendra Kumar et al., IJSID, 2011, 1 (3), 395-421Figure-42: Purity plot of Metformin from Dry-Heat stress studyFigure-43: Placebo chromatogram from Dry-Heat stress studyFigure-44: Drug product chromatogram from Humidity stress studyInternational Journal of Science Innovations and Discoveries Vol 1, Issue 3, November-December 2011414
Thamma Narendra Kumar et al., IJSID, 2011, 1 (3), 395-421Figure-45: Purity plot of Metformin from Humidity stress studyFigure-46: Placebo chromatogram from Humidity stress studyPrecision: The precision of the method verified by Repeatability and Intermediate precision. Repeatability waschecked by injecting six individual preparations of Metformin Hydrochloride Tablet powder. % RSD of assayresults was calculated. The intermediate precision of the assay method was evaluated by different analysts andperforming the analysis on different days and with different <strong>HPLC</strong> instruments and columns.The % RSD of assay of Metformin Hydrochloride during the assay method precision study was 1.0 %. The% RSD of the assay results obtained in the intermediate precision study was within the limit (1.1) conforming goodrepeatability of the method. The % RSD values were represented in table-3.International Journal of Science Innovations and Discoveries Vol 1, Issue 3, November-December 2011415
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