General research objectives - DPZ

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Department of Veterinary Medicine and Primate Husbandry Progress during the year Since the merger of the Working Groups 'Experimental Pathology' and 'Breeding and Animal Husbandry' with the 'Department of Pathology and Veterinary Care', the new Department of Veterinary Medicine and Primate Husbandry has become the main DPZ infrastructure department. Tasked by the Scientific Advisory Committee, its main objective is to guarantee and optimize all DPZ services. Infrastructural services include animal breeding, animal acquisition and sale, the provision of quarantine, all aspects of veterinary care including diagnostic services in pathology, bacteriology and parasitology, and management of the veterinary pharmacy. The tasks provided by the Animal Welfare Officer and Infectious Disease Officer, both of whom are required by law, also continue to be of central importance. Another service is the management of the central electron microscopy laboratory, which is used by internal and external groups. A case from diagnostic pathology: Severe alterations of the knee occurring during chronic purulent gonitis in a barbary ape (Macaca sylvanus). The promotion of the former Acting Head of department to the position of Professor of Experimental Animal Pathology at the School of Veterinary Sciences in Hannover, together with his promotion to Head of Department until 2005, ensures the continuation of the Department‘s service-oriented research and guarantees a further optimization of infrastructure. Apart from management of its internal research programme, its services also include the management of projects carried out for external partners. Currently joint projects include: • Co-operation with the School of Medicine, Hannover, on Xenotransplantation of transgenic pig kidneys to cynomolgus monkeys (Macaca fascicularis); • Co-operation with the Research Center, Jülich, in the testing of image processing procedures on the CNS of baboons (Papio hamadryas); • Co-operation with Aachen Hospital in research on the pathogenesis of nephropathy in marmosets (Callithrix jacchus) as a model for human kidney disease; • Co-operation with four European institutions as part of an EU-Programme on estimating the risks of transmissible spongiform encephalopathies. 30 Primate Report 60, July 2001
Department of Veterinary Medicine and Primate Husbandry The research programme of the department reflects the particular needs of the service sector, with the pathology of infections representing a major focus. Most work is carried out jointly with the Department of Virology and Immunology and centres on two important infectious diseases in primates, both of which are relevant to veterinary and human medicine: • SIV-infection in rhesus monkeys (Macaca mulatta) • Helicobacter-infections in non-human primates SIV-Infection in rhesus monkeys Section of a plasma cell showing intracytoplasmic tubuloreticular structures (X) and so-called Russel Bodies (RB) in the dilated cisterns of the endoplasmic reticulum (er). Transmission electron microscope, Lamina propria of the rectum, SIV-infected rhesus monkey 12 weeks post-infection. Diss. Bruno (2000) The animal model of SIV-infection involves collaboration with the Department of Virology and Immunology at the DPZ, Homburg University, Würzburg University, Erlangen-Nürnberg University and the BNI in Hamburg. Our own research focuses on primary SIV-induced alterations and the pathogenic processes accompanying opportunistic infections, where the spread of the virus in the lymphatic tissues and the gut-associated mucosal immune system is of particular interest. Other investigations focus on the pathogenesis of SIV-associated lymphomas and primary SIVinduced CNS alterations. Primate Report 60, July 2001 31
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General research objectives - DPZ

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