ECHA - Guidance of the application of CLP criteria [November 2012]

More documents

Recommendations

Info

Guidance on the Application of the CLP Criteria Version 3.0 - November 2012Example D: Hazard classification of a soluble metal salt: the case of rapidenvironmental transformation through speciation in the watercolumn.................................................................................................552VVIANNEX V: COLLECTION OF INTERNET LINKS FOR THE USERS OF THEGUIDANCE ......................................................................................................................................555ANNEX VI: BACKGROUND DOCUMENT TO THE GUIDANCE FOR SETTINGSPECIFIC CONCENTRATION LIMITS FOR SUBSTANCES CLASSIFIED FORREPRODUCTIVE TOXICITY ACCORDING TO REGULATION (EC) NO 1272/2008..............5561 Executive summary ..............................................................................................................5562 Introduction ..........................................................................................................................5572.1 General description of the classification system for reprotoxic substancesand mixtures ..........................................................................................................5572.2 Description of the process for the development of a method to set SCLs forreproductive toxic substances................................................................................5582.3 Considering potency in setting specific concentration limits for varioushealth hazards........................................................................................................5592.4 Parameters for potency for reproductive toxicity..................................................5603 Modifying factors .................................................................................................................5644 Non-modifying factors .........................................................................................................5654. 1 Species and strains ................................................................................................5654. 2 Systemic or maternal toxicity................................................................................5654. 3 Mutagenicity .........................................................................................................5654.4 Volatility ...............................................................................................................5655 Potency groups and specific concentration limits.................................................................5665.1 Justification of the proposed potency boundaries and specific concentrationlimits......................................................................................................................5665.2 Assigning SCLs.....................................................................................................5726 References ............................................................................................................................57226
Guidance on the Application of the CLP Criteria Version 3.0 - November 2012LIST OF ABBREVIATIONSADNADRANEASTMATEBAMBCFBCOPBfRBfR DSSBMFBPbwC&LCAcATpECLPCNSCSACSRAccord européen relatif au transport international des marchandises dangereuses parvoie de navigation intérieure (European Agreement concerning the InternationalCarriage of Dangerous Goods by Inland Waterways) 3Accord européen relatif au transport international des marchandises dangereuses parroute (European Agreement concerning the International Carriage of Dangerous Goodsby Road) 4Ammonium Nitrate EmulsionAmerican Society for the Testing of MaterialsAcute Toxicity EstimateBundesanstalt für Materialforschung und -prüfung (Federal Institute for MaterialsResearch and Testing)Bioconcentration FactorBovine Corneal Opacity and Permeability testGerman Federal Institute for Risk AssessmentDecision support system by the German Federal Institute for Risk AssessmentBiomagnification factorBoiling pointBody weightClassification and LabellingCompetent AuthorityConverted Acute Toxicity point EstimateRegulation (EC) No 1272/2008 on classification, labelling and packaging ofsubstances and mixtures 5Central Nervous SystemChemical Safety AssessmentChemical Safety ReportDINStandard of the German Institute for StandardisationDNA Deoxyribonucleic AcidDOC Dissolved Organic CarbonDPD Directive 1999/45/EC on the classification and labelling of Dangerous Preparations 6DSD Directive 67/548/EEC on the classification and labelling of Dangerous Substances 73 European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways,concluded at Geneva on 26 May 2000, as amended4 European Agreement concerning the International Carriage of Dangerous Goods by Road, concluded at Genevaon 30 September 1957, as amended5 Regulation (EC) No 1272/2008 of the European Parliament and Council of 16 December 2008 onclassification, labelling and packaging of substances and mixtures, amending and repealing Directives67/548/EEC and 1999/45/EC and amending Regulation (EC) No 1907/2006 [OJ L 353, 31.12.2008, p. 1]6 Directive 1999/45/EC of the European Parliament and of the Council of 31 May 1999 concerning theapproximation of the laws, regulations and administrative provisions of the Member States relating to theclassification, packaging and labelling of dangerous preparations [OJ L 200, 30.7.1999, p. 1]27
Page 2 and 3: Guidance on the Application of the
Page 76 and 77:
Guidance on the Application of the
Page 78 and 79:
Page 80 and 81:
Page 82 and 83:
Page 84 and 85:
Page 86 and 87:
Page 88 and 89:
Page 90 and 91:
Page 92 and 93:
Page 94 and 95:
Page 96 and 97:
Page 98 and 99:
Page 100 and 101:
Page 102 and 103:
Page 104 and 105:
Page 106 and 107:
Page 108 and 109:
Page 110 and 111:
Page 112 and 113:
Page 114 and 115:
Page 116 and 117:
Page 118 and 119:
Page 120 and 121:
Page 122 and 123:
Page 124 and 125:
Page 126 and 127:
Page 128 and 129:
Page 130 and 131:
Page 132 and 133:
Page 134 and 135:
Page 136 and 137:
Page 138 and 139:
Page 140 and 141:
Page 142 and 143:
Page 144 and 145:
Page 146 and 147:
Page 148 and 149:
Page 150 and 151:
Page 152 and 153:
Page 154 and 155:
Page 156 and 157:
Page 158 and 159:
Page 160 and 161:
Page 162 and 163:
Page 164 and 165:
Page 166 and 167:
Page 168 and 169:
Page 170 and 171:
Page 172 and 173:
Page 174 and 175:
Page 176 and 177:
Page 178 and 179:
Page 180 and 181:
Page 182 and 183:
Page 184 and 185:
Page 186 and 187:
Page 188 and 189:
Page 190 and 191:
Page 192 and 193:
Page 194 and 195:
Page 196 and 197:
Page 198 and 199:
Page 200 and 201:
Page 202 and 203:
Page 204 and 205:
Page 206 and 207:
Page 208 and 209:
Page 210 and 211:
Page 212 and 213:
Page 214 and 215:
Page 216 and 217:
Page 218 and 219:
Page 220 and 221:
Page 222 and 223:
Page 224 and 225:
Page 226 and 227:
Page 228 and 229:
Page 230 and 231:
Page 232 and 233:
Page 234 and 235:
Page 236 and 237:
Page 238 and 239:
Page 240 and 241:
Page 242 and 243:
Page 244 and 245:
Page 246 and 247:
Page 248 and 249:
Page 250 and 251:
Page 252 and 253:
Page 254 and 255:
Page 256 and 257:
Page 258 and 259:
Page 260 and 261:
Page 262 and 263:
Page 264 and 265:
Page 266 and 267:
Page 268 and 269:
Page 270 and 271:
Page 272 and 273:
Page 274 and 275:
Page 276 and 277:
Page 278 and 279:
Page 280 and 281:
Page 282 and 283:
Page 284 and 285:
Page 286 and 287:
Page 288 and 289:
Page 290 and 291:
Page 292 and 293:
Page 294 and 295:
Page 296 and 297:
Page 298 and 299:
Page 300 and 301:
Page 302 and 303:
Page 304 and 305:
Page 306 and 307:
Page 308 and 309:
Page 310 and 311:
Page 312 and 313:
Page 314 and 315:
Page 316 and 317:
Page 318 and 319:
Page 320 and 321:
Page 322 and 323:
Page 324 and 325:
Page 326 and 327:
Page 328 and 329:
Page 330 and 331:
Page 332 and 333:
Page 334 and 335:
Page 336 and 337:
Page 338 and 339:
Page 340 and 341:
Page 342 and 343:
Page 344 and 345:
Page 346 and 347:
Page 348 and 349:
Page 350 and 351:
Page 352 and 353:
Page 354 and 355:
Page 356 and 357:
Page 358 and 359:
Page 360 and 361:
Page 362 and 363:
Page 364 and 365:
Page 366 and 367:
Page 368 and 369:
Page 370 and 371:
Page 372 and 373:
Page 374 and 375:
Page 376 and 377:
Page 378 and 379:
Page 380 and 381:
Page 382 and 383:
Page 384 and 385:
Page 386 and 387:
Page 388 and 389:
Page 390 and 391:
Page 392 and 393:
Page 394 and 395:
Page 396 and 397:
Page 398 and 399:
Page 400 and 401:
Page 402 and 403:
Page 404 and 405:
Page 406 and 407:
Page 408 and 409:
Page 410 and 411:
Page 412 and 413:
Page 414 and 415:
Page 416 and 417:
Page 418 and 419:
Page 420 and 421:
Page 422 and 423:
Page 424 and 425:
Page 426 and 427:
Page 428 and 429:
Page 430 and 431:
Page 432 and 433:
Page 434 and 435:
Page 436 and 437:
Page 438 and 439:
Page 440 and 441:
Page 442 and 443:
Page 444 and 445:
Page 446 and 447:
Page 448 and 449:
Page 450 and 451:
Page 452 and 453:
Page 454 and 455:
Page 456 and 457:
Page 458 and 459:
Page 460 and 461:
Page 462 and 463:
Page 464 and 465:
Page 466 and 467:
Page 468 and 469:
Page 470 and 471:
Page 472 and 473:
Page 474 and 475:
Page 476 and 477:
Page 478 and 479:
Page 480 and 481:
Page 482 and 483:
Page 484 and 485:
Page 486 and 487:
Page 488 and 489:
Page 490 and 491:
Page 492 and 493:
Page 494 and 495:
Page 496 and 497:
Page 498 and 499:
Page 500 and 501:
Page 502 and 503:
Page 504 and 505:
Page 506 and 507:
Page 508 and 509:
Page 510 and 511:
Page 512 and 513:
Page 514 and 515:
Page 516 and 517:
Page 518 and 519:
Page 520 and 521:
Page 522 and 523:
Page 524 and 525:
Page 526 and 527:
Page 528 and 529:
Page 530 and 531:
Page 532 and 533:
Page 534 and 535:
Page 536 and 537:
Page 538 and 539:
Page 540 and 541:
Page 542 and 543:
Page 544 and 545:
Page 546 and 547:
Page 548 and 549:
Page 550 and 551:
Page 552 and 553:
Page 554 and 555:
Page 556 and 557:
Page 558 and 559:
Page 560 and 561:
Page 562 and 563:
Page 564 and 565:
Page 566 and 567:
Page 568 and 569:
Page 570 and 571:
Page 572 and 573:
show all

ECHA - Guidance of the application of CLP criteria [November 2012]

Create successful ePaper yourself

Delete template?

Save as template?