ECHA - Guidance of the application of CLP criteria [November 2012]

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Guidance on the Application of the CLP Criteria Version 3.0 - November 2012EC3ECBECHAECVAMEDEffective Concentration inducting a stimulation index of 3 in the LLNA testEuropean Chemicals BureauThe formerly known European Chemicals Bureau (ECB) was part of the Institute forHealth and Consumer Protection (IHCP), which is one of the seven scientific institutesin the European Commission's Joint Research Centre (JRC). Its mission was to providescientific and technical support to the conception, development, implementation andmonitoring of EU policies on chemicals and consumer products.(http://ecb.jrc.ec.europa.eu/)European Chemicals Agency, Helsinki (http://echa.europa.eu/home_en.asp)European Centre for the Validation of Alternative Methods (http://ecvam.jrc.it/)Effective DoseERVEcotoxicity Reference ValueESAC ECVAM Scientific Advisory Committee (http://ecvam.jrc.it/)f/FFemaleFPFlash pointGCLGeneral Concentration LimitsGHS Globally Harmonised System of Classification and Labelling of Chemicals 8GJICGLPGnRHGPMTGVHbHET-CAMHSHSMHtIARCIATA(DGR)IBCICAO TIICEIECIMDGGap junction intercellular communicationGood Laboratory PracticeGonadotropin-releasing hormoneGuinea Pig Maximisation TestGuidance ValueHaemoglobinHen's Egg Test on Chorio-allantoic MembraneHazard statementHuman skin modelHematocritInternational Agency for Research on Cancer (http://www.iarc.fr/)International Air Transport Association (Dangerous Goods Regulations Manual)Intermediate Bulk ContainerInternational Civil Aviation Organization (Technical Instructions for the SafeTransport of Dangerous Goods by Air)Isolated Chicken EyeInternational Electrotechnical Commission (http://www.iec.ch/)International Maritime Dangerous Goods Code7 Council Directive 67/548/EEC of 27 June 1967 on the approximation of laws, regulations and administrativeprovisions relating to the classification, packaging and labelling of dangerous substances [OJ 196, 16.8.1967, p.1]8 Globally Harmonised System of Classification and Labelling of Chemicals (GHS), Second revised edition,United Nations New York and Geneva, 200728
Guidance on the Application of the CLP Criteria Version 3.0 - November 2012INS Guidance on Identification and Naming of Substances under REACH, ECHA, 2007(http://guidance.echa.europa.eu/docs/guidance_document/substance_id_en.pdf)IPCS International Programme on Chemical Safety (joint programme of WHO, ILO andUNEP)IR/CSAIREISOGuidance on Information Requirements and Chemical Safety Assessment, ECHA,2008(http://guidance.echa.europa.eu/docs/guidance_document/information_requirements_en.htm)Isolated Rabbit EyeInternational Standards OrganisationITDG Directive 2008/68 on the Inland Transport of Dangerous Goods 9ITSLD 50 /LC 50LLNALO (A) EL/CLVETm/MMetHBMetHbMPMSCAMTDMWn.a.NCNENO(A)ECNO(A)ELODSODPOECDOECD TGIntegrated Testing StrategyMedian (50%) lethal dose/concentrationLocal Lymph Node AssayLowest Observed (Adverse) Effect Level/ConcentrationLow Volume Eye TestMaleMethaemoglobinaemiaMethaemoglobinMelting PointMember State Competent AuthorityMaximal Tolerated DoseMolecular weightNot availableNo ClassificationNarcotic effect(s)No Observed (Adverse) Effect ConcentrationNo Observed (Adverse) Effect LevelOzone Depleting SubstancesOzone Depleting PotentialOrganisation for Economic Co-operation and DevelopmentOECD Test GuidelineThe OECD Guidelines for the Testing of Chemicals are a collection of the mostrelevant internationally agreed test methods used by government, industry andindependent laboratories to determine the safety of chemicals and chemical mixtures,including pesticides and industrial chemicals. All Test Guidelines are available at the9 Directive 2008/68/EC of the European Parliament and of the Council of 24 September 2008 on the inlandtransport of dangerous goods, implementing the European Agreement concerning the International Carriageof Dangerous Goods by Road (ADR), the Regulations concerning the International Carriage of DangerousGoods by Rail (RID) and the European Agreement concerning the International Carriage of Dangerous Goodsby Inland Waterways (ADN) [OJ L 260, 30.9.2008, p. 13]29
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ECHA - Guidance of the application of CLP criteria [November 2012]

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