GHS (CLP/GHS system) IN PRACTICE - Agencija za hemikalije

NOTE: It is important to make sure that you choose the most appropriate method foryour mixture for each hazard class or category!Depending on the information available and on the hazard under consideration you should classify using theapproaches below in the following sequence:1. Using data on the mixture itself1. The mixture as a whole is tested2. The classification criteria are applied as for a substance3. Not applicable for CMR and some environmental hazard classes, but mandatory for physical hazards2. Classification based on the application of bridging principlesBridging principles are used for classifying untested mixtures. When a mixture has not been tested, but there aresufficient data on the components and/or similar tested mixtures, these data can be used in accordance with thefollowing bridging principles:• Diluting: if a mixture is diluted with a diluent that has an equivalent or lower toxicity, then thehazards of the new mixture are assumed to be equivalent to the original• Batching: if a batch of a complex substance is produced under a controlled process, thenthe hazards of the new batch are assumed to be equivalent to the previous batches• Concentration of highly toxic mixtures: if a mixture is severely hazardous, then aconcentrated mixture is also assumed to be severely hazardous• Interpolation within one toxicity category: mixtures having component concentrations withina range where the hazards are known are assumed to have those known hazards• Substantially Similar Mixtures: slight changes in the concentrations of components are notexpected to change the hazards of a mixture and substitutions involving toxicologicallysimilar components are not expected to change the hazards of a mixture• Aerosols: an aerosol form of a mixture is assumed to have the same hazards as the tested,non-aerosolized form of the mixture unless the propellant affects the hazards upon spraying.All bridging principles do not apply to every health and environmental endpoint. Consult each endpoint todetermine which bridging principles apply!3. Classification based on the concentration of individual ingredients (using the Tables on genericconcentration limits from CLP/GSH Rulebook)3.1 Additive concentration limits• Skin corrosion/irritation• Serious eye damage/eye irritation• STOT SE, Cat. 3• Hazardous to the aquatic environment3.2 Non- additive concentration limits• Sensitisers (respiratory and skin)• CMR• STOT SE and RE, Cat 1-2• Aspiration hazard• Hazardous to the ozone layer4. Calculation using formulas (acute toxicity)Classification based on concentrations and the acute toxicity (ATE-values) of the ingredients by using the additivityformula.21