GHS (CLP/GHS system) IN PRACTICE - Agencija za hemikalije

Parathion 0,002 LC 50 Fish, Lepomis macrochirus, 96 h = 18 µg/LButyl benzylphthalate (BBP)Nonylphenol 0,021log Kow= 3,15BCF = 400Not rapidly degradableErC 50 Algae (Selenastrum capricornutum), 72 h = 0,2 mg/LEC 50 Daphnia magna, 48 h = 2,2 mg/Llog Kow= 4.7BCF = 663 – 772Rapidly degradableEC 50 Crustacea, 48 h = 0,0207 mg/LLC 50 Fish, Lepomis macrochirus, 96 h = 0,128 mg/llog Kow= 4.5BCF = 1300Not rapidly degradableSolution:You should first determine the CLP/GHS classification of the substances in the mixture and then the classificationof the mixture using the criteria for environmental hazards in Part 4 of Annex I to CLP/GHS Rulebook.Classification of the substances in the mixtureFirst determine the correct classification and the M-factors of the three substances by using Table 4.1.0 and 4.1.3of (Annex I of CLP/GHS Regulation); this is as follows:Parathion:Category 1 for acute toxicityCategory 1 for chronic toxicityM-factor = 1000BBP:Nonylphenol:Category 1 for acute toxicityCategory 1 for chronic toxicityM-factor = 1Category 1 for acute toxicityCategory 1 for chronic toxicityM-factor = 10Classification of the mixtureDetermine the correct classification of the mixture using the summation method in Tables 4.1.1 and 4.1.2 inAnnex I of CLP/GHS Regulation. Do this separately for the classification of acute and long-term hazards. For thelong-term hazards, begin with the most stringent classification, Chronic category 1. If this does not apply, analysefor classification as Chronic category 2, and so on:Category 1 for acute toxicity: (0,002% x 1000) + (1% x 1) + (0,02% x 10) = 3,2% (< 25%)Conclusion: no classification for acute toxicityCategory 1 for chronic toxicity: (0,002% x 1000) + (1% x 1) + (0,02 x 10) = 3,2 % (< 25%)Conclusion: Chronic category 1 does not apply; continue →Category 2 for chronic toxicity: (0,002% x 1000 x 10) + (1% x 1 x 10) + (0,02% x 10 x 10) == 32% ( > 25%) →Result:27