July 2005 - The Hong Kong College of Anaesthesiologists
July 2005 - The Hong Kong College of Anaesthesiologists
July 2005 - The Hong Kong College of Anaesthesiologists
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Bull HK Coll Anaesthesiol Volume 14, Number 2 <strong>July</strong> <strong>2005</strong>ConclusionIn summary, we observed severepsychomimetic adverse reactions aftersubcutaneous ketamine infusion. We do notrecommend the use <strong>of</strong> ketamine forpostoperative pain relief until more informationon side effect pr<strong>of</strong>ile <strong>of</strong> such regime is available.AcknowledgementWe wish to thank Dr Adam Tucker (email:research@southernhealth.org.au) for histhoughtful suggestion.References1. Willets J, Balster RL, Leander JD. <strong>The</strong>behavioral pharmacology <strong>of</strong> NMDAreceptor antagonists. Trends Pharmacol Sci1990;11:423‐28.2. Ilkjaer S,Petersen KL, Brennum J, et al. Effect<strong>of</strong> systemic NMDA receptor antagonist(ketamine) on primary and secondaryhyperanalgesia in humans. Br J Anaesth1996;76:829‐34.3. Dickenson AH. Spinal cord pharmacology<strong>of</strong> pain.Br. J. Aneasth. 1995;75:193‐200.4. Schmid RL, Sandler AN, Katz J. Use andefficacy <strong>of</strong> low‐dose ketamine in themanagement <strong>of</strong> acute postoperative pain: areview <strong>of</strong> current techniques and outcomes.Pain 1999;82:111‐25.5. Bhattacharya A, Gurnani A, Sharma PK,Sethi AK. Subcutaneous infusion <strong>of</strong>ketamine and morphine for relief <strong>of</strong>postoperative pain: a double blindcomparative study. Ann Acad MedSingapore 1994;23:456‐9.6. L, Sinclair DD, Van Hasselt CH. Intravenousketamine for postoperative analgesia. S AfrMed J 1975;49:1437‐40.7. Dich‐Nielsen JO, Svendsen LB, Berthelsen P.Intramuscular low‐dose ketamine versuspethidine for postoperative pain treatmentafter thoracic surgery. Acta AnaesthesiolScand 1993;6:861‐5.8. Jhangir SM, Islam F, Aziz L. Ketamineinfusion for postoperative analgesia inasthmatics: a comparison with intermittentmeperidine. Anesth Analg 1993;76:45‐9.9. Javery KB, Ussery TW, Steger HG,Colclough GW. Comparison <strong>of</strong> morphineand morphine with ketamine forpostoperative analgesia. Can J Anesth1996;43:212‐5.10. Joachimsson PO, Hedstrand U, Eklund A.Low‐dose ketamine infusion for analgesiaduring postoperative ventilator treatment.Acta Anaesthesiol Scand 1986;30:697‐702.11. Maurset A, Skoglund LA, Hustveit O, Oye I.Comparison <strong>of</strong> ketamine and pethidine inexperimental and postoperative pain. Pain1989;36:37‐41.12. Owen H, Reekie RM, Clements JA, WatsonR, Nimmo WS. Analgesia from morphineand ketamine. A comparison <strong>of</strong> infusion <strong>of</strong>morphine and ketamine for postoperativeanalgesia. Anaesthesia 1987;42:1051‐6.13. Sethna NF, Liu M, Gracely R, Bennett GJ,Max MB. Analgesic and cognitive effects <strong>of</strong>intravenous ketamine‐alfentanil combinationversus either drug alone afterintradermal capsaicin in normal subjects.Anesth Analg 1998;86:1250‐6.14. Stubhaug A, Breivik H, Eide PK, Kreunen M,Foss A. Mapping <strong>of</strong> punctuatehyperhyalgesia around a surgical incisiondemonstrates that ketamine is a powerfulsuppressor <strong>of</strong> central sensitization to painfollowing surgery. Acta Anaesthesiol Scand1997;41:1124‐32.15. White PF, Way WL, Trevor AJ.Pharmacology <strong>of</strong> ketamine ‐ its pharmacologyand its therapeutic uses. Anesthesiology1982;56:119‐36.16. Wilder‐Smith OH, Arentdt‐Nielsen L,Gaumann D, Tassonyi E, Rifat KR. Sensorychanges and pain after abdominalhysterectomy; a comparison <strong>of</strong> anaesthethicsupplementation with fentanyl versusmagnesium or ketamine. Anesth Analg1998;86:95‐101.17. Krystal JH, Karper LP, Seibyl JP, et al.Subanaesthetic effects <strong>of</strong> the noncompetitiveNMDA antagonist, ketamine, in humans.Psychotomimetic, perceptual, cognitive and88
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