Modern surgical treatment of otosclerosis - Helda - Helsinki.fi

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Contents LIST OF ORIGINAL PUBLICATIONS 7 ABBREVIATIONS 8 ABSTRACT 9 TIIVISTELMÄ (FINNISH SUMMARY) 11 1 INTRODUCTION 13 2 REVIEW OF THE LITERATURE 15 2.1 Definition of otosclerosis 15 2.2 Histology of otosclerosis 15 2.4 Epidemiology 16 Histological otosclerosis 16 Clinical otosclerosis 17 2.3 Aetiology 17 Genetic inheritance 18 Viral aetiology 18 Endocrinological factors 19 Immunological factors 19 2.5 Clinical findings and pathogenesis of otosclerosis 20 Conductive hearing loss 20 Sensorineural hearing loss 21 Vestibular symptoms 22 Tinnitus 22 Otosclerosis and Meniere’s disease 23 2.6 Diagnosis 23 Audiological evaluations 23 Radiological evaluations 24 2.7 Surgical treatment 25 Stapedectomy versus stapedotomy 26 Prosthesis 26 Sealing 28 Lasers in primary surgery 28 4
Stapedius tendon preservation 29 Results of primary and revision surgery 30 Surgical treatment of bilateral otosclerosis 31 Cochlear implantation 33 2.8 Complications 33 Perioperative complications 33 Sensorineural hearing loss 34 Perilymph fistula 35 Reparative granuloma 36 Vertigo 36 Taste disturbance 37 Facial paresis 37 Suppurative labyrinthitis and meningitis 38 Radiological evaluation of postoperative SNHL 38 2.9 Conservative treatment 39 Hearing aid 39 Medical treatment 39 3 AIMS OF THE STUDY 41 4 MATERIALS AND METHODS 42 4.1 Study design 42 Study I 42 Study II 42 Studies III and IV 43 4.2 Surgery 43 4.3 Objective measurements and analysis 44 Video-oculography 44 Visual feedback posturography 45 Audiogram 45 Statistical analysis 45 4.4 Ethical aspects 46 5 RESULTS AND COMMENTS 48 5.1 Simultaneous bilateral surgery (I) 48 5.2 Outpatient surgery (II) 50 5
Page 1 and 2: Department of Otorhinolaryngology U
Page 3: To my Family
Page 7 and 8: List of original publications The t
Page 9 and 10: Abstract Abstract The era of modern
Page 11 and 12: Tiivistelmä (Finnish summary) Tiiv
Page 13 and 14: 1 Introduction Introduction Otoscle
Page 15 and 16: 2 Review of the literature 2.1 Defi
Page 17 and 18: Clinical otosclerosis Review of the
Page 19 and 20: Review of the literature examinatio
Page 21 and 22: Review of the literature hearing lo
Page 23 and 24: Otosclerosis and Meniere’s diseas
Page 25 and 26: Review of the literature is positiv
Page 27 and 28: Review of the literature and light-
Page 29 and 30: Review of the literature shorter wa
Page 31 and 32: Review of the literature The analys
Page 33 and 34: Review of the literature Twenty-eig
Page 35 and 36: Review of the literature demonstrat
Page 37 and 38: Review of the literature disturb th
Page 39 and 40: Review of the literature images. In
Page 41 and 42: 3 Aims of the study Aims of the stu
Page 43 and 44: Studies III and IV Materials and me
Page 45 and 46: Materials and methods Study III inc
Page 47 and 48: Materials and methods Figure 2. Vis
Page 49 and 50: Results and comments improved signi
Page 51 and 52: Results and comments Table 3. Heari
Page 53 and 54: Results and comments A final follow
Page 55 and 56:
Results and comments spontaneous ho
Page 57 and 58:
Discussion The patient also would a
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Discussion surgeries are suitable f
Page 61 and 62:
Discussion Patients with vestibular
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7 Conclusions Conclusions Audiologi
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Acknowledgements Most of my writing
Page 67 and 68:
References Baloh RW, Honrubia. Clin
Page 69 and 70:
References Dahlqvist A, Diamant H,
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References Gersdorff M, Nouwen J, G
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References Jablokow VR, Kathuria S.
Page 75 and 76:
References Markou K, Goudakos J. An
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References Perkings RC. Laser stape
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References Shabana YK, Ghonim MR, P
Page 81 and 82:
References Toner JG, Smyth GDL. Com
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Appendix Questionnaire used to asse
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