Pulmonary Hypertension: Beyond the Swan Ganz Catheter
Pulmonary Hypertension: Beyond the Swan Ganz Catheter
Pulmonary Hypertension: Beyond the Swan Ganz Catheter
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Serotonin and PHTN• Syn<strong>the</strong>sized in pulmonary endo<strong>the</strong>lium– Rate limiting step is activity of tryptophan hydroxylase1(Tph1)• Serotonin can– pass into <strong>the</strong> underlying pulmonary smooth muscle cellsthrough <strong>the</strong> serotonin transporter (SERT) to initiateproliferation– activate serotonin receptors on pulmonary smooth musclecells to evoke proliferation and contraction– mediates pulmonary fibroblast proliferation via <strong>the</strong> SERTand serotonin receptors