- Page 1: Pulmonary Hypertension:Beyond the S
- Page 5 and 6: Hard to Manage• RV performance pr
- Page 7 and 8: ETIOLOGY
- Page 9 and 10: Stimulus• Precipitating stimulus
- Page 11 and 12: Plexiform Lesionshttp://www.som.tul
- Page 13 and 14: Components• Thromboxane A 2 (TXA
- Page 15 and 16: Nitric Oxide and cGMPhttp://www.hea
- Page 17 and 18: PATHOPHYSIOLOGY
- Page 19 and 20: Increased Venous Pressurehttp://www
- Page 21 and 22: PHTN Hemodynamic ConsequencesPHTNRV
- Page 23 and 24: 2003 World Symposium on Pulmonary A
- Page 25 and 26: Classification Divisions• PAH- Fa
- Page 27 and 28: Pulmonary Arterial Hypertension•
- Page 29 and 30: Associated Conditions• Associated
- Page 31 and 32: HIV and PHTN• Affects 0.5 to 6% o
- Page 33 and 34: Anorectic Drugs• Etiology: Likely
- Page 35 and 36: Hemoglobinopathies• Sickle cell,
- Page 37 and 38: Pulmonary Veno‐Occlusive Disease
- Page 39 and 40: Left Heart Disease• LV diastolic
- Page 41 and 42: Left Sided Valvular Disease• Aort
- Page 43 and 44: PHTN associated with lung diseases
- Page 45 and 46: Thromboembolic Disease• Endotheli
- Page 47 and 48: Acute PE• Associated with mild PH
- Page 49 and 50: Postoperative PHTN• Cardiac and t
- Page 51 and 52: Initial Symptoms• Progressive SOB
- Page 53 and 54:
WHO Classification of SymptomsClass
- Page 55 and 56:
PFT’s• Normal expiratory flow r
- Page 57 and 58:
ECGwww.aafp.org
- Page 59 and 60:
CT Scanwww.emedicine.com/RADIO/topi
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Echocardiography• Noninvasive•
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Diagnosis• Echocardiography- Can
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Diagnostic Tests• Detecting pulmo
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Diagnostic Tests• CT- Main PA dia
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GENERAL THERAPIES ANDTREATMENT
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Oxygen• Hypoxia strong stimulus f
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Diuretics• Reduce edema, hepatic
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Anticoagulation• No RCT evidence
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Calcium Channel Blockers• Respond
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SPECIFIC TREATMENTS
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Prostacyclin Analogs• Metabolite
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Prostacyclin Analogs• Epoprosteno
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Action of Current PHTN TherapiesPre
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Phosphodiesterase Inhibitors• Cas
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Endothelin Receptor Agonists• Mod
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Action of Current PHTN TherapiesPre
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Nitric Oxidehttp://www.healthway-ct
- Page 95 and 96:
Inhaled Nitric Oxide• Not approve
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SURGICAL OPTIONS
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Pulmonary Endarterectomy• Pulmona
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Atrial Septostomy• Done only for
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Gene Therapy• For patients with g
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Serotonin and PHTN• Synthesized i
- Page 107 and 108:
Serotonin Antagonists• 32 patient
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SSRI Therapy• Retropsective study
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Statins• Girgis, R. E. et al. (20
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Conclusions• Have a high suspicio
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At Risk Patients and ScreeningRiskS
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References• Barnett, C. F., Hsue,
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References• Johnson, S. R., Mehta