performance on the assignments, and the classdiscussions.SYSTEMS BIOLOGY OF GENETICS,GENOMICS AND PROTEOMICS GS6284 Credit Hours<strong>Course</strong> Coordinator:Dr. David AmbergPrerequisite(s): GS616 Foundations of Molecularand Cellular BiologyGS617 Introduction to Applied Biostatics andResearch DesignPeriod Offered:Spring, odd years<strong>Course</strong> Description: The goal of this course is totrain graduate students in modern experimentaland theoretical methods to perform systems levelinvestigations into modern questions in genetics,genetic influences on human disease and geneexpression. The course is divided into 4 sectionswith 4 exams. The focus of section 1 is to providethe student with a basic understanding of thegenetics of inheritance, how to study complexgenetic interactions and how genomic approachescan be used to define genetic networks. The focus ofsection 2 is on genome organization, evolution, andpopulation genetics. Section 3 considers linkage andassociation analysis for identifying genetic influenceson human disease, QTL studies, mouse genetics, andthe use of microarrays for systems level expressionanalysis, linkage analysis and network construction.The course finishes with a comprehensive coverageof protein identification and sequencing by massspectrometry,proteome identification by massspectrometry,and data analysis of proteome datafor delineation of protein complexes and expressionprofiling.Location:Room 3109 Weiskotten HallBIOMOLECULAR X-RAY DIFFRACTION:THEORETICAL BASIS ANDEXPERIMENTAL PROCEDURES GS6324 Credit Hours<strong>Course</strong> Coordinator:Debashis Ghosh, PhDInstructors:Drs. Edward Berry,Stephan Wilkens, Stewart Loh, Thomas Duncan,Ziwei Huang, Michael Cosgrove (Syracuse Univ.),Wenhua Jiang and Debashis Ghosh.Period Offered:Fall, odd yearsLectures:Mondays and Fridays (10-11 AM)Labs/Computer Labs:Wednesdays 1-4 pmLab in RM 230 Library(the first hour is set aside for lecture / instruction /introduction to the project, followed by 2 hours’ ofhands on project / lab work)<strong>Course</strong> Description: An introduction to the theoryand practices of X-ray diffraction and crystallographicmethods applicable to the elucidation of structurefunctionrelationships of biological moleculesand interactions thereof. The course is designedto provide a comprehensive understanding ofthe basic principles through in-depth theoreticaldiscussion, extensive problem solving and hands-onexperimental and computational steps through thebiomolecular structure solution process. The coursealso provides hands-on exposure to computationaltools, such as homology modeling, docking andnormal mode analysis. Prerequisite: undergraduate(senior level) biochemistry, chemistry, physics orphysical chemistry or permission of the instructor.Objectives: Essential for graduate studentspursuing X-ray crystallographic analysis of biologicalmacromolecules in particular and structural biologyin general for their thesis work, the course offers aunique opportunity in the <strong>SUNY</strong> <strong>Upstate</strong>-ESF-SUcorridor to gain comprehensive background andtraining in one of the most informative state-ofthe-artbiophysical techniques as applied to theelucidation and analysis of three-dimensionalstructures of biological macromolecules andutilization thereof.33
ORTHOPEDIC BASIC SCIENCE1 Credit Hours Hour/semesterOBS610Instructor(s): Megan Oest, Ph.D. (Coordinator),and members of the Orthopedic Surgeryand Research FacultyPrerequisite(s): Permission of course coordinatorPeriod offered:Fall/Spring<strong>Course</strong> Description: This course is intended toprovide a broad overview of basic musculoskeletalscience for graduate studies. It is also taken byorthopedic residents and medical students withinterest in orthopedics. Biweekly 1 hour lecturesare given over the entire academic year by expertsclosest to their respective subjects. This coursecovers, in broad perspective, the basic principlesthat underlie the function of the elements of themusculoskeletal system including their form andfunction, growth and development, injury andrepair. Topics include: articular cartilage, tendons,ligaments, skeletal muscle, bone, physeal function,intervertebral disc, molecular and cellular biologyof bone and musculoskeletal tissues, peripheralnerve injury and repair, biomechanical fundamentalbioelectricity, orthopedic biomaterials, geneticsand the skeleton, prosthetics and orthotics, andprinciples of experimental design.While there are not stated Prerequisite(s): ,prospective students should obtain permission ofthe course coordinator prior to registration.Textbook(s): Orthopedic Basic Science, S.R. Simon,edit., American Academy of Orthopedic Surgeons34