Septocoll® E - Biomet

Septocoll ® E – Quality MattersEquine collagenGood fibrinogenesisBiocompatibleEase of handlingThe starting material for the manufacture of Septocoll Econsists of natural, pure collagen fibrils extracted from horsetendons. These are both fully resorbable and water-insoluble.High-Tech ProductA complex freeze-drying process connects the collagenfibrils to form a mesh (Fig. 01). The special manufacturingprocedure produces a fleece with a large, active surfaceand good moisture stability. Unlike other collagen fleeces,which typically adhere to surgical instruments or wetgloves, Septocoll E does not stick.Hemostatic EffectIn contact with blood, collagen causes platelet aggregation.Large numbers of platelets accumulate on the collagenfleece and release coagulation factors like thrombin. Inconjunction with plasma factors these induce fibrinogenesis.ResorptionComplete resorption of the collagen fleece takes placewithin approximately four weeks – depending on localblood circulation – by way of phagocytosis and enzymaticdegradation (3) .Fig. 01Type I collagen with high biocompatibility and low immunogenicitySeptocoll E contains exclusively type I collagen, which isbest suited for biological degradation. Notable propertiesin this connection are high biocompatibility and lowimmunogenicity, as well as good controllability of resorptionvia cross-linking agents (4) .The collagen used in Septocoll E is well tolerated andsupports the patient’s convalescence through significantlyshorter wound healing times (5) .4