Septocoll® E - Biomet

Septocoll ® E – PharmacokineticsGentamicin sulfate:Rapid releaseGentamicin crobefate:Protracted releaseg100050010050105g1 2 3 4 5 6 7 8 9 10 Tage DaysCollagen fleece with gentamicin sulfate and gentamicin crobefateCollagen fleece with gentamicin sulfateMIC (Minimum Inhibitory Concentration)1000Fig. 04500Fleeces only impregnated with gentamicin sulfatereleased 90% of their gentamicin sulfate content100within 48 hours. Fleeces also impregnated with50gentamicin crobefate, however, released gentamicinover a period of 10 days (18) .1051 2 3 4 5 6 7 8 9 10 TageSeptocoll E contains two gentamicin salts, which – basedon their active substance content – are combined at a ratioof 1:1. They have different release kinetics.High Initial ConcentrationGentamicin sulfate is highly water-soluble: The antibioticis therefore released rapidly from the carrier material. Thisleads to a very high initial gentamicin concentration at thesite of action. Within a short time, however, this level dropsagain to below the minimum inhibitory concentration (MIC)for causative microbes.Lasting EffectGentamicin crobefate is a gentamicin salt that we developedin-house. It is less watersoluble than the sulfate and cantherefore release the gentamicin on a protracted basis atthe site of action. Aside from the high initial concentration,therefore, the antibiotic’s release from the fleece iscontrolled. The gentamicin crobefate gives the Septocoll Efleece its distinctive yellow color.Fleeces only impregnated with gentamicin sulfate released90% of their gentamicin sulfate content within 48 hours.Fleeces also impregnated with gentamicin crobefate,however, released gentamicin over a period of 10days (18, 19) (Fig. 04).6