Septocoll® E - Biomet

Septocoll ® E – Safety FirstThe antibiotic gentamicin has been used successfully insurgical wound care for many years (6, 7, 8, 9, 10, 11, 12, 13, 14) .Gentamicin still has a good resistance profile.Local or SystemicGentamicin can be administered systemically (Fig. 02) orlocally (Fig. 03). If applied locally, however, substantiallygreater concentrations of antibiotics accumulate at the siteof action than when it is administered systemically. At thesame time, serum concentrations – and therefore potentialadverse effects – are significantly lower (8, 15) .Dual Principle of ActionDue to its collagen matrix, Septocoll E induces hemostasisand promotes wound healing; in addition, because ofthe gentamicin contained in Septocoll E, a local antibioticprotection is also provided.Site of actionAntibioticSerumExcretionLocal application:Lower serum and urine concentrationsFewer adverse effectsDual principle of action:Hemostasis and antibiotic protectionTissue/OrganThis dual principle of action — hemostasis and antibioticprotection — is provided by Septocoll E throughouttreatment because the protracted release of thegentamicin ensures additional protection against secondaryinfections during the resorption phase of the fleece. Theapplication of Septocoll E can therefore be recommendedas a hemostat for:• potentially contaminated woundsAntibioticFig. 02Systemic application: high strain on the body with lowconcentration at the site of action• contaminated wounds• revision operations in septic surgerySite of actionSerumTissue/OrganExcretionThe application of Septocoll E has been documented innumerous studies (1, 4, 5, 16, 17) .Fig. 03Local application: high concentration at the site ofaction with little effect on the body5