Welcome to SBS 2011 - SLAS

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SBS 17th Annual Conference & Exhibition Advancing the Science of Drug Discovery Thought-Provoking Keynote Presentations Thought-provoking presentations by impressive scientific pacesetters offer personal insights into innovation and achievement. Learn from them and be inspired by them. Monday, March 28, 8:30 – 11:00 am Location: Osceola A SBS Achievement Award Winner; 9:00 am Robert J. Lefkowitz, M.D., Duke University School of Medicine, Durham, North Carolina 18 | SLAS.org/events/sbs11 Beta Arrestin Mediated Signaling by 7 Transmembrane Receptors: New Therapeutic Opportunities Robert J. Lefkowitz studies receptor biology and signal transduction and is best known for his detailed characterizations of the sequence, structure and function of the beta-adrenergic receptor and the proteins required for its regulation. Upon recognizing the sequence and functional homology with the visual protein rhodopsin, Dr. Lefkowitz proposed that adrenergic receptors and rhodopsin were related and the first members of a new protein family, the seven transmembrane receptors or G-protein coupled receptors. This superfamily is now known to be the largest, most diverse, and most therapeutically accessible. Author or co-author of more than 800 publications, Dr. Lefkowitz is among the most highly cited researchers in the fields of biology, biochemistry, pharmacology, toxicology, and clinical medicine according to Thomson-ISI. SBS Accomplishment Award Winner; 10:00 am Brian Shoichet, Ph.D., University of California, San Francisco, San Francisco, California Mechanism and Effects of Colloidal Aggregation in Early Discovery and Drug Pharmacology Research in the Shoichet Lab at the University of California, San Francisco seeks to bring chemical reagents to biology, using a combination of computational simulation and experiment. Using a protein- centric approach, new ligands are sought to complement protein structures. This typically involves molecular docking and the development of model experimental systems to experimentally test new algorithms. A new direction adopts a ligand-centric approach that seeks new targets for known drugs and reagents. Whereas this lacks the physical foundation of structure-based docking, it returns to an older, pharmacological view of biological relationships, bringing to it a quantitative model. A biological focus for both areas is the discovery of reagents to modulate GPCRs. This research is supported by the National Institutes of Health. Thursday, March 31, 12:00 – 1:30 pm Location: Osceola A Hugh Rosen, M.D., Ph.D., The Scripps Research Institute, Scripps, Florida Allostery and S1P Receptors: A Syzygy of Pharmacology and High-Resolution Crystal Structure Approaches to S1P1 receptor therapeutics will be presented, including uHTS approaches, pharmacological clues for allostery, pocket mapping by mutagenesis, insights from a high-resolution S1P1 crystal structure, implications for signal bias and the biological consequences of receptor modulation.
Your SLAS Membership Keeps You On Top of the Latest in Scientific Research and Discovery Welcome to the Society for Laboratory Automation and Screening (SLAS). Your membership makes you an integral part of an international community of more than 10,000 dedicated academic, industrial and government scientists, engineers and informatics professionals, and science-and technology-focused product development, marketing and sales specialists. Our community is committed to continuing education for those concentrated on research and discovery through laboratory science and technology. As part of this community and as a member of SLAS, you’ll have access to scientific educational opportunities, such as leading conferences and exhibitions, global symposia and virtual courses. You’ll glean practical information and insights through tools such as our world-renowned wiki LabAutopedia and our extensive online product directory The Market Place—each helping you to increase the effectiveness and efficiency of your work. And, you’ll find professional career-building and valuable networking opportunities that can open many doors to personal and professional success. SLAS Membership Highlights: Scientific Education • SLAS scientific conferences and exhibitions, global symposia, in-person and virtual courses • SLAS on-demand learning, offering numerous presentations from past events • LabAutopedia—our collaborative online compilation of the world’s laboratory technology knowledge Award-Winning Information Resources • The Journal of Biomolecular Screening (JBS): the leading peer-reviewed journal focusing on drug discovery sciences • The Journal of Laboratory Automation (JALA): the only peer-reviewed, multi-disciplinary international forum devoted exclusively to the advancement of technology Career-Building Resources • SLAS Career Connections—our totally automated and interactive employment program SLAS.org—The online hub of the SLAS community • Event information and access • The Learning Center, including the educational resources listed above and more • Access to information resources such as academic screening centers, standards and more • Member directories • The Market Place—a robust online product directory that places hundreds of new and existing technology products and services at your fingertips • Online directories of resources, institutions, terminology, and procedures • State-of-the-art social networking forums and special interest groups dedicated to information exchange in the laboratory • SBS News • The Buzz e-Newsletter • LabSnap e-Newsletter • The SLAS.org industry news RSS feed, updated daily • Career advice from professional career coaches • Special Interest Groups (SIGs) • Awards and grant information • Career resources • Industry news RSS feed • SLAS-specific news The Society for Laboratory Automation and Screening—Rich in Education, Information and Career Resources. Maximize your membership and take advantage of all that is available to help you advance laboratory science and technology. For membership information, call +1.877.990.SLAS (7527).
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Epigenetic Assays Check Out Our New
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PORTFOLIO: • 700,000 screening co
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Gaylord Palms Resort and Convention
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The Label-Free 384-Well Revolution
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Use All That SLAS Offers You to Tra
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