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SBS 17th Annual Conference & Exhibition Advancing the Science of Drug Discovery Micro-and Nanofluidic Devices for Cancer Screening and Virus Sensing Stephen C. Jacobson, Indiana University Interest in microfluidics has increased over the past decade primarily because device miniaturization enables execution of fast, efficient, high throughput assays, integration of multiple sample processing steps, and fabrication of highly parallel device architectures. One important aspect is that the separative performance measured per unit length on microfluidic devices is similar to or exceeds that of conventional capillary separations. This high performance is due, in part, to the precise sample handling on the microfluidic devices. Precise sample handling combined with a compact serpentine channel geometry permits us to develop high-efficiency electrophoretic separations of N-glycans for screening applications. Presently, we are analyzing N-glycans derived from blood serum samples of patients with esophageal adenocarcinoma, high-grade dysplasia, and Barrettís esophagus and comparing the results with those from disease-free individuals. Statistical analysis of the electropherograms permits discriminatation among the various disease states. We are also shrinking the lateral dimensions of micromachined channels to nanometer length scales for resistive-pulse sensing of virus particles. Some aspects of microchannel transport transfer directly to operation of smaller nanoscale channels, but nanofluidic systems can be significantly influenced by phenomena such as double layer overlap, surface charge, ion current rectification, diffusion, and entropic forces, which are either insignificant or absent in larger microchannels. We are studying transport properties of ions and particles through these nanochannel devices and applying what we have learned to sense virus particles and to monitor their assembly under various reaction conditions. Perfusion Culture Microchamber Array Chip for High-Throughput Cell-Based Assay Shinji Sugiura, National Institute of Advanced Industrial Science and Technology (AIST) We report a perfusion culture microchamber array chip for high throughput drug dose response assays. The developed microchamber array chip was equipped with a serial dilution microfluidic network and an array of 384 microchambers for parallel quadruplicate assays using 12 drugs with 8 varying concentrations, which was confirmed to be applicable to the 50 percent growth inhibitory concentration (IC50) assay. We also report a liquid handling apparatus and an incubation unit for semi-automatic operations. Well Plate Microfluidic Devices for Investigation of Dynamic Platelet Behavior Under Variable Shear Loads Carolyn Conant, Fluxion Biosciences Here, we report development of a commercial well plate microfluidic (WPM) based system that offers high throughput, low reagent consumption, and high experimental flexibility in an easy to use well plate format. The system consists of well plates with an integrated array of microfluidic channels, a pneumatic interface, an automated microscope, and a software package for control and data acquisition. 38 | SLAS.org/events/sbs11
Gaylord Palms Resort and Convention Center | March 27–31, 2011 | Orlando, Florida, USA Podium Presentation Abstracts Monday, March 28 Track II: Translational Research; Session 1: Resources and Collaborative Paradigms in Academia, Not-for-Profit and Industry Session Chairs: Paul Burn, Sanford Research Center Location: Osceola C 1:30 – 2:00 pm Plenary: Putting Research into Practice Paul Burn, Sanford Research Center 2:00 – 2:30 pm Changing the Rules for the Research “Game” in Academia - Accelerating Discovery Through Novel Means of Collaboration Mark Atkinson, The University of Florida 3:00 – 3:30 pm Collaboration as a Central Strategy for Successful Translational Research John Reed, Sanford-Burnham Medical Research Institute 3:30 – 4:00 pm Challenges and Successes of Translational Research in the Public Domain: Retrospective and Prospective Analyses and Case Histories of “Probes to Leads” From Six Years of the Molecular Libraries Program Thomas “T.C.” Chung, Conrad Prebys Center for Chemical Genomics at Sanford-Burnham Medical Research Institute 4:00 – 4:30 pm Translation in Action: MRCT’s Centre for Therapeutics Discovery Justin Bryans, MRC Technology SLAS.org/events/sbs11 | 39
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The Label-Free 384-Well Revolution
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