Welcome to SBS 2011 - SLAS

Gaylord Palms Resort and Convention Center | March 27–31, 2011 | Orlando, Florida, USA
Label-Free/Biophysics Methods for
Screening
Location: Osceola 5
Biophysical/label-free methods are becoming an important
tool in lead finding and drug discovery complementing, but not
replacing, more classical assay technologies. A collection of
long-standing, “gold-standard” label-free methods are rapidly
being augmented by novel, higher throughput techniques,
presenting both an extensive but also confusing landscape
of biophysics tools in drug discovery. A key question is how
to enable efficient and more systematic use of the biophysics
portfolio in early drug discovery programs. Ultimately they
are expected to offer not only novel ways of hit finding, but
also more efficient ways to identify and advance true hits for
chemistry and later stage biology. This course focuses on
those “biochemical” biophysics technologies with highest
impact and applicability for screening and lead finding (e.g.
protein thermal denaturation and aggregation [DSF aka
Thermofluor, DSLS aka Stargazer]; SPR, interferometry and
waveguide grating [e.g. SPR aka Biacore, Corning Epic, SRU
BIND, BLI aka Fortebio]; NMR; calorimetry (DSC, ITC); mass
spectrometry; dynamic light scattering]. In the focus of this
short course are biochemical assay applications and the
detection, quantification and qualification of ligand/protein
binding events.
Instructors
Johannes Ottl, Novartis Pharma NIBR (Lead Instructor);
Delphine Collin, Boehringer Ingelheim Pharmaceuticals, Inc.;
Kristin Coan, Novartis Pharma AG
High-Content Screening
Location: Osceola 6
High-content screening is a powerful technology platform
for implementing functional cell-based assays that allow
truly multiparametric analysis in the physiological context
of intact cells. This course provides a state-of-the-art overview
of the components of HCS (instrumentation, fluorescent labels,
HC assay development, automated image analysis and
multi-parametric data analysis) together with some showcases
of small molecule and RNAi high-content screens in industry
and academia.
Instructors
Eberhard Krausz, Janssen Research & Development (J&J)
(Lead Instructor); Stephan C. Schurer, The Scripps Research
Institute Florida; Vance Lemmon, University of Miami;
James G. Evans, Anon Consulting
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