Computerized Training of Working Memory in Children with ADHD ...
Computerized Training of Working Memory in Children with ADHD ...
Computerized Training of Working Memory in Children with ADHD ...
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<strong>ADHD</strong>, WM and medication<strong>ADHD</strong> genetics• Stimulant medication (methylphenidate)improves WM– Kempton 1999– Barnett 2001– Bedard 2004– Mehta 2004Heritability 0.76DRD4DRD5DATDBH5-HTTHTR1BSNAP-25Faraone et al. 2005•DLPFC• Inferior parietal• Basal ganglia• Orbit<strong>of</strong>rontal• Anterior c<strong>in</strong>gulate• Cerebellum<strong>ADHD</strong> anatomy<strong>Work<strong>in</strong>g</strong> memoryWM and <strong>ADHD</strong><strong>ADHD</strong>Dopam<strong>in</strong>eKl<strong>in</strong>gberg et al. (2002)Can WM be improved by tra<strong>in</strong><strong>in</strong>g?<strong>Computerized</strong> <strong>Tra<strong>in</strong><strong>in</strong>g</strong> <strong>of</strong><strong>Work<strong>in</strong>g</strong> <strong>Memory</strong>• 40 m<strong>in</strong> tra<strong>in</strong><strong>in</strong>g / day• 5 days/week, 5 weeks• Adaptive algorithm• Internet based feedbackIf so, does improved WM:- effect others areas <strong>of</strong> cognition?- effect symptoms?Later developed <strong>with</strong> thecompany Cogmed4
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