Cardiology1.6.4 Coronary artery interventionalproceduresPercutaneous coronary intervention (PCI)After coronary angioplasty the recurrence or restenosisrate is 30% within 3 months and 40%–60% <strong>for</strong> total occlusions that are successfullydilated as treatment of acute MI. These figures havebeen greatly reduced, first by bare metal stents andthen further by drug-eluting stents. Drug-elutingstents are covered by an antimitotic agent to preventsmooth muscle/fibrous tissue proliferation. Un<strong>for</strong>tunately,they also inhibit endothelialisation so increasingthe risk of thrombosis and so dualantiplatelet therapy (aspirin and clopidogrel) is mandatory<strong>for</strong> 12 months after the intervention andlifelong single antiplatelet therapy is required thereafter.• Lesions particularly amenable to PCI includethose that are discrete, proximal, non-calcified,unoccluded, that are away from side branchesand that occur in patients with a short history ofangina. While there is a small acute occlusionrate, these can usually be managed successfullywith intra-coronary stenting, such that the need<strong>for</strong> emergency CABG has fallen to under 1%• More challenging lesions include those withingrafts, at bifurcations, calcified or long lesionsand those within small vessels. Diabetics havepoorer outcomes compared with non-diabetics• Almost any lesion can be stented including leftmain stem disease, three-vessel disease andeven chronic total occlusions but carefulevaluation and discussion with the patient arenecessary, as in many situations bypass graftinghas a better evidence baseCoronary artery bypass grafting (CABG)CABG has clear benefits in specific groups of patientswith chronic coronary artery disease (whencompared with medical therapy alone). Analysis haspreviously been limited because randomised trialsincluded small numbers and were per<strong>for</strong>med severaldecades ago; patients studied were usuallymales aged ,65 years. The population now receivingCABG has changed, but so has medical therapy.• Prognostic benefits are shown <strong>for</strong> symptomatic,significant left main stem disease (Veterans’Study), symptomatic proximal three-vesseldisease and in two-vessel disease whichincludes the proximal left anterior descendingartery (CASS data)• Patients with moderately impaired leftventricular function show greater benefit, butthose with poor left ventricular function havegreater operative mortality. Overall mortality is,2%, rising to between 5% and 10% <strong>for</strong> asecond procedure. Eighty per cent of patientsgain symptom relief• Peri-operative graft occlusion is around 10% <strong>for</strong>vein grafts, which otherwise last 8–10 years.Arterial grafts (internal mammary, free radial,gastro-epiploic) have a higher initial patencyrate but long-term outcomes are disappointingwith the exception of internal mammary grafts,which are clearly superior to vein grafts• A ‘Dressler-like’ syndrome may occur up to6 months post-surgery• Minimally invasive CABG involves theredirection of internal mammary arteries tocoronary vessels without the need <strong>for</strong> cardiacbypass and full sternotomy incisions (oftentermed ‘off pump’ coronary revascularisation).Recovery times following this procedure areshorter than <strong>for</strong> conventional surgery but theprocedures are technically more challengingPost-MI rehabilitationAfter MI patients are kept in hospital <strong>for</strong> 5 days,should take 2 months off work and have 1 month’sabstinence from sexual intercourse and driving (seefollowing text). Cardiac rehabilitation is particularlyimportant <strong>for</strong> patient confidence. Depression occursin 30% of patients. Patients who are fully revascularisedor invasively investigated and found to haveno ongoing ischaemic focus may be dischargedafter 3 days and be rehabilitated more rapidly.Fitness to driveThe DVLA provides extensive guidelines <strong>for</strong> coronarydisease and interventions. Their website(www.dvla.gov.uk) should be consulted, especially37
<strong>Essential</strong> <strong>Revision</strong> <strong>Notes</strong> <strong>for</strong> <strong>MRCP</strong>Table 1.8. Fitness to driveCondition Driving restriction <strong>Notes</strong>Unexplained syncope6 months from lastepisode or until effectivetreatment is givenClear vasovagal events that occur onlywhen the patient is erect do not precludedrivingCardiac catheter procedure (includingangiography, percutaneous coronaryintervention, electrophysiologicalstudies/ablation)Myocardial infarction1 week Should be able to per<strong>for</strong>m emergency stopunhindered1 monthPermanent pacemaker 1 month Only 1 week if the patient has never beensyncopalProphylactic ICD 1 month No clinical arrhythmia or syncopeSecondary prevention ICD 6 months DVLA must be in<strong>for</strong>medICD shock therapy 6 months Unless an inappropriate shock ispreventable by reprogramming orintervention, eg a change in the detectionor therapy programming to avoid shocks<strong>for</strong> sinus tachycardia or atrial arrhythmiaswith regard to class 2 licences (<strong>for</strong> vehicles over3500 kg, minibuses and buses) but the essentialpoints are given in Table 1.8.1.7 OTHER MYOCARDIAL DISEASES1.7.1 Cardiac failureCardiac failure can be defined as the pumpingaction of the heart being insufficient to meet thecirculatory demands of the body (in the absence ofmechanical obstructions). A broad echocardiographicdefinition is of an ejection fraction (EF),40% (as in the SAVE trial, which enrolled patients<strong>for</strong> ACE inhibitors post-MI). Overall 5-year survivalis 65% with EF ,40%, compared to 95% in thosewith EF .50%.The most common single cause of cardiac failure inthe Western world is ischaemic heart disease (IHD).• Hypertension is also a very frequent cause –either acting alone or in combination with IHD• Diastolic heart failure is increasingly recognisedalthough difficult to diagnose as an isolatedcondition. It describes impaired ventricularfilling that elevates pulmonary and/or systemicvenous pressure with activation of theneurohormonal system as seen in systolic heartfailure• All patients with systolic heart failure have adegree of diastolic dysfunction – some believethat isolated diastolic dysfunction may be anearly step prior to development of systolic heartfailureEF is only a guide to cardiac function, which alsodepends on other factors including pre-load, after-38