Ca - LISM
Ca - LISM
Ca - LISM
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<strong>Ca</strong> outSlippage and LeakSlippageATPhydrolysis<strong>Ca</strong> out<strong>Ca</strong> inE1E2E1<strong>Ca</strong> 2E2P iE2PE1<strong>Ca</strong> ATP2<strong>Ca</strong> inE2P<strong>Ca</strong> 2transportmM <strong>Ca</strong>passiveleakslippage<strong>Ca</strong> outSlippage<strong>Ca</strong> accumulated(nmoles/mg)50004000300020001000PC + 10%cardiolipinIncreasingslippagePC+10%PAPC00 500 1000Time (secs)