Ca - LISM

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Sarcoplasmic reticulum contains sarcolipinMERSTRELCLNFTVVLITVILIWLLVRSYQYCa accumulation (nmoles/mg protein)20001500100050010:120:100 200 400 600 800 1000 1200Time (secs)SLN:ATPase02:15:1ATP hydrolysisslippagemM CaSarcolipin inceases slippage
SarcoplasmicReticulumNerveDepolarisation Muscle CellSynapsePlasma membraneCa 2+ Ca 2+ T systemCa 2+2+Ca channelCa 2+ Ca 2+TnCATP ADP + P iActinMyosinRoles of SR: accumulate CaThermogenesisSarcolipinAnionic Lipid
Page 1: Saulieu October 2004Protein-Lipid I
Page 4 and 5: Lipid as solventBacteriorhodopsinLi
Page 6 and 7: The importance of Annular LipidThe
Page 8 and 9: Effect of Lipid headgroupCalcium AT
Page 14 and 15: Calcium accumulation (nmoles/mg pro
Page 16 and 17: Ca outSlippage and LeakSlippageATPh
Page 18 and 19: SarcoplasmicReticulumNerveDepolaris
Page 26 and 27: How efficient is hydrophobic matchi
Page 28 and 29: Reconstituted KcsAPhosphatidylcholi
Page 30 and 31: Hydrophobic MismatchBilayer Distort
Page 32 and 33: Fluorescence quenchingin mixtures o
Page 34 and 35: Relative binding constant2.01.51.00
Page 36 and 37: RCalcium ATPaseChangingBilayer thic
Page 38 and 39: Diacylglycerol kinase of E. coliPer
Page 40 and 41: Hydrophobic mismatchCalcium ATPaseC
Page 42 and 43: Fluorescence quenchingTrp containin
Page 44 and 45: Hydrophobic matching between the bi
Page 46 and 47: Trp at ends of helices are not cons
Page 48 and 49: Use of Trp fluorescence to define h
Page 50 and 51: D6825 A O L69V91L92R11Y94D16
Page 52 and 53: KcsAnon-annularlipidanionicannularl
Page 54 and 55: KcsA Trp quenchingnon-annularoF/F1.
Page 56 and 57: Lipid-Protein InteractionsAnnular l

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