Greg Calligaro Definition and classification of pulmonary hypertension

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Group 1: Congenital heart disease• Pulmonary blood volumeoverload from intracardiacshunting• Left-to-right shunts are mostcommon, especially VSDs• PAH can also occur in patientswith ASDs
PAH related to schistosomiasis• Pathogenesis originallythought to be embolic• Plexiform lesions observedin pathological studies• Portal <strong>hypertension</strong>independent risk factor• Egg impaction may act astrigger for:– oxidative stress– inflammation– endothelial dysfunctionRoss E et al. NEJM, 2002.
Page 1 and 2: Definition andclassification ofpulm
Page 3 and 4: Haemodynamic definition of pulmonar
Page 5: PH: importance of PCWP• Identifie
Page 9 and 10: WHO Group 1 PAH1. PAH•Idiopathic
Page 11 and 12: Group 1: PAH associated with HIV in
Page 13: PAH related to portal hypertension
Page 18 and 19: Group 1’: PVOD and PCH• Ground
Page 20 and 21: Changes to WHO Group 1 (Dana Point
Page 22 and 23: Group 2: Left heart diseaseNormalTi
Page 24 and 25: Group 3: Secondary to lung disease/
Page 26 and 27: Group 4: CTEPH• Most pulmonary em
Page 28 and 29: Pathophysiology• “Two compartme
Page 30 and 31: Group 4: CTEPH
Page 32 and 33: Group 5: Unclear or multifactorial
Page 34 and 35: Summary• Pulmonary hypertension i

Greg Calligaro Definition and classification of pulmonary hypertension

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