Greg Calligaro Definition and classification of pulmonary hypertension
Greg Calligaro Definition and classification of pulmonary hypertension
Greg Calligaro Definition and classification of pulmonary hypertension
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Pathophysiology• “Two compartment <strong>pulmonary</strong> vascular bed” model:– one compartment obstructed by organising thrombus,but with normal downstream vessel calibre <strong>and</strong>histology– one compartment exposed to increased flow,increased shear stresses remodelling <strong>of</strong> smallarteries predisposition to thrombosisHigh PAP = sum <strong>of</strong> proximal PEs +distal small vessel arteriopathyHoeper M et al, Chronic Thromboembolic Pulmonary Hypertension, Circulation 2006.
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